Rabbit Polyclonal GABA A Receptor alpha 2/GABRA2 antibody. Suitable for WB and reacts with Mouse samples. Cited in 20 publications.
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- Journal of food and drug analysis 31:278-2882023Sleep-promoting activity of amylase-treated Ashwagandha (Withania somnifera L. Dunal) root extract via GABA receptors.Applications:Unspecified applicationReactive species:Unspecified reactive speciesChun Woong Park,Ki-Bae Hong,Hyung Joo Suh,Yejin AhnPubMed 37335157
- Pharmaceutical biology 60:1341-13482022Sleep-promoting activity of lotus () rhizome water extract via GABA receptors.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYejin Ahn,Singeun Kim,Chunwoong Park,Jung Eun Kim,Hyung Joo Suh,Kyungae JoPubMed 35840545
- Frontiers in molecular neuroscience 15:8264272022Loss of KCC2 in GABAergic Neurons Causes Seizures and an Imbalance of Cortical Interneurons.Applications:Unspecified applicationReactive species:Unspecified reactive speciesKirill Zavalin,Anjana Hassan,Cary Fu,Eric Delpire,Andre H LagrangePubMed 35370549
- International journal of molecular sciences 22:2021Fermented Gamma Aminobutyric Acid Improves Sleep Behaviors in Fruit Flies and Rodent Models.Applications:Unspecified applicationReactive species:Unspecified reactive speciesA-Hyun Jeong,Jisu Hwang,Kyungae Jo,Singeun Kim,Yejin Ahn,Hyung Joo Suh,Hyeon-Son ChoiPubMed 33805468
- Molecular neurobiology 57:4978-49882020Layers II/III of Prefrontal Cortex in Df(h22q11)/+ Mouse Model of the 22q11.2 Deletion Display Loss of Parvalbumin Interneurons and Modulation of Neuronal Morphology and Excitability.Applications:Unspecified applicationReactive species:Unspecified reactive speciesAbdel-Rahman Al-Absi et. al.PubMed 32820460
- eLife 9:2020MeCP2 in cholinergic interneurons of nucleus accumbens regulates fear learning.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYing Zhang et. al.PubMed 32420873
- Brain and behavior 10:e015762020Simultaneous intrathecal injection of muscimol and endomorphin-1 alleviates neuropathic pain in rat model of spinal cord injury.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMarjan Hosseini et. al.PubMed 32189472
- The Journal of clinical investigation 129:2333-23502019CB1 agonism prolongs therapeutic window for hormone replacement in ovariectomized mice.Applications:Unspecified applicationReactive species:Unspecified reactive speciesKun Zhang et. al.PubMed 31063987
- Molecular brain 12:362019Anxiolytic effects of Formononetin in an inflammatory pain mouse model.Applications:Unspecified applicationReactive species:Unspecified reactive speciesXin-Shang Wang et. al.PubMed 30961625
- British journal of pharmacology 176:297-3162018Metformin produces anxiolytic-like effects in rats by facilitating GABA receptor trafficking to membrane.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJun Fan,Di Li,Hong-Sheng Chen,Jian-Geng Huang,Jun-Feng Xu,Wen-Wen Zhu,Jian-Guo Chen,Fang WangPubMed 30318707
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.5
Constituents: 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, 0.238% HEPES, 0.01% BSA- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- The exact immunogen used to generate this antibody is proprietary information.
Reactivity data
Select an application| WB | |
|---|---|
| Human | Predicted |
| Mouse | Tested |
| Cow | Predicted |
| Dog | Predicted |
| Primates | Predicted |
| Zebrafish | Predicted |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info 1/1000 | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Cow, Dog, Human, Primates, Zebrafish | Dilution info - | Notes - |
Associated Products
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3 products for Alternative Product
Target data
Function
Alpha subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:27129275). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s) (By similarity). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (By similarity). Chloride influx into the postsynaptic neuron following GABAAR opening decreases the neuron ability to generate a new action potential, thereby reducing nerve transmission (By similarity). The alpha-2 subunit exhibits synaptogenic activity together with beta-2 and very little to no activity together with beta-3, the gamma-2 subunit being necessary but not sufficient to induce rapid synaptic contacts formation (PubMed:27129275).
Alternative names
Gabra-2, Gabra2, Gamma-aminobutyric acid receptor subunit alpha-2, GABA(A) receptor subunit alpha-2, GABAAR subunit alpha-2
Recommended products
Rabbit Polyclonal GABA A Receptor alpha 2/GABRA2 antibody. Suitable for WB and reacts with Mouse samples. Cited in 20 publications.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.5
Constituents: 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, 0.238% HEPES, 0.01% BSA- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- The exact immunogen used to generate this antibody is proprietary information.
- Purification technique
- Affinity purification Immunogen
- Specificity
ab72445 is specific for GABA A Receptor alpha 2/GABRA2
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
1 product image
Western blot - Anti-GABA A Receptor alpha 2/GABRA2 antibody (ab72445)
All lanes: Western blot - Anti-GABA A Receptor alpha 2/GABRA2 antibody (ab72445) at 1/1000 dilution
Lane 1: Wild type Mouse brain lysates
Lane 2: GABA A Receptor alpha 2/GABRA2 knockout mouse brain lysate
Predicted band size: 51 kDa
Observed band size: 51 kDa
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