AB72445

Anti-GABA A Receptor alpha 2/GABRA2 antibody

Name: Anti-GABA A Receptor alpha 2/GABRA2 antibody (ab72445) | Abcam
Brand: Abcam Limited
SKU: AB72445
Price: 535 USD
Availability: InStock
Rating: 3 (1 reviews)

(1 Review)

(24 Publications)

Rabbit Polyclonal GABA A Receptor alpha 2/GABRA2 antibody. Suitable for WB and reacts with Mouse samples. Cited in 24 publications.

View Alternative Names

Gabra-2, Gabra2, Gamma-aminobutyric acid receptor subunit alpha-2, GABA(A) receptor subunit alpha-2, GABAAR subunit alpha-2

1 Images

Supplier Data

Western blot - Anti-GABA A Receptor alpha 2/GABRA2 antibody (AB72445)

All lanes:

Western blot - Anti-GABA A Receptor alpha 2/GABRA2 antibody (ab72445) at 1/1000 dilution

Lane 1:

Wild type Mouse brain lysates

Lane 2:

GABA A Receptor alpha 2/GABRA2 knockout mouse brain lysate

Predicted band size: 51 kDa

Observed band size: 51 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Mouse

Applications

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

Specificity

ab72445 is specific for GABA A Receptor alpha 2/GABRA2

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000", "WB-species-notes": "<p></p>" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Dog": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Primates": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Zebrafish": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.5 Constituents: 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, 0.238% HEPES, 0.01% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Alpha subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed : 27129275). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s) (By similarity). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (By similarity). Chloride influx into the postsynaptic neuron following GABAAR opening decreases the neuron ability to generate a new action potential, thereby reducing nerve transmission (By similarity). The alpha-2 subunit exhibits synaptogenic activity together with beta-2 and very little to no activity together with beta-3, the gamma-2 subunit being necessary but not sufficient to induce rapid synaptic contacts formation (PubMed : 27129275).

See full target information Gabra2

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Publications (24)

Recent publications for all applications. Explore the full list and refine your search

Advanced science (Weinheim, Baden-Wurttemberg, Germany) 11:e2400205 PubMed38965798

2024

Wheel-Running Exercise Alleviates Anxiety-Like Behavior via Down-Regulating S-Nitrosylation of Gephyrin in the Basolateral Amygdala of Male Rats.

Applications

Unspecified application

Species

Unspecified reactive species

Ping-Fen Yang,Tai-Lei Nie,Xia-Nan Sun,Lan-Xin Xu,Cong Ma,Fang Wang,Li-Hong Long,Jian-Guo Chen

Journal of dairy science 107:8811-8823 PubMed38825137

2024

Improvement of sleep duration and quality through GABA receptor by whey protein hydrolysate containing DIQK as the main active compound.

Applications

Unspecified application

Species

Unspecified reactive species

Hyowon Lee,Hyeongyeong Kim,Cheng-Min Jin,Hyeon-Son Choi,Hyung Joo Suh,Yeok Boo Chang

Journal of food and drug analysis 31:278-288 PubMed37335157

2023

Sleep-promoting activity of amylase-treated Ashwagandha (Withania somnifera L. Dunal) root extract via GABA receptors.

Applications

Unspecified application

Species

Unspecified reactive species

Chun Woong Park,Ki-Bae Hong,Hyung Joo Suh,Yejin Ahn

Pharmaceutical biology 60:1341-1348 PubMed35840545

2022

Sleep-promoting activity of lotus () rhizome water extract via GABA receptors.

Applications

Unspecified application

Species

Unspecified reactive species

Yejin Ahn,Singeun Kim,Chunwoong Park,Jung Eun Kim,Hyung Joo Suh,Kyungae Jo

Frontiers in molecular neuroscience 15:826427 PubMed35370549

2022

Loss of KCC2 in GABAergic Neurons Causes Seizures and an Imbalance of Cortical Interneurons.

Applications

Unspecified application

Species

Unspecified reactive species

Kirill Zavalin,Anjana Hassan,Cary Fu,Eric Delpire,Andre H Lagrange

International journal of molecular sciences 22: PubMed33805468

2021

Fermented Gamma Aminobutyric Acid Improves Sleep Behaviors in Fruit Flies and Rodent Models.

Applications

Unspecified application

Species

Unspecified reactive species

A-Hyun Jeong,Jisu Hwang,Kyungae Jo,Singeun Kim,Yejin Ahn,Hyung Joo Suh,Hyeon-Son Choi

Molecular neurobiology 57:4978-4988 PubMed32820460

2020

Layers II/III of Prefrontal Cortex in Df(h22q11)/+ Mouse Model of the 22q11.2 Deletion Display Loss of Parvalbumin Interneurons and Modulation of Neuronal Morphology and Excitability.

Applications

Unspecified application

Species

Unspecified reactive species

Abdel-Rahman Al-Absi,Per Qvist,Samora Okujeni,Ahmad Raza Khan,Simon Glerup,Connie Sanchez,Jens R Nyengaard

Neuropharmacology 179:108277 PubMed32818520

2020

PSD-95 deficiency alters GABAergic inhibition in the prefrontal cortex.

Applications

Unspecified application

Species

Unspecified reactive species

Erin P McEachern,Austin A Coley,Sha-Sha Yang,Wen-Jun Gao

eLife 9: PubMed32420873

2020

MeCP2 in cholinergic interneurons of nucleus accumbens regulates fear learning.

Applications

Unspecified application

Species

Unspecified reactive species

Ying Zhang,Yi Zhu,Shu-Xia Cao,Peng Sun,Jian-Ming Yang,Yan-Fang Xia,Shi-Ze Xie,Xiao-Dan Yu,Jia-Yu Fu,Chen-Jie Shen,Hai-Yang He,Hao-Qi Pan,Xiao-Juan Chen,Hao Wang,Xiao-Ming Li

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 17:1253-1270 PubMed32297184

2020

Activation of LXRβ Signaling in the Amygdala Confers Anxiolytic Effects Through Rebalancing Excitatory and Inhibitory Neurotransmission upon Acute Stress.

Applications

Unspecified application

Species

Unspecified reactive species

Wen Yu,Lu Wang,Le Yang,Yan-Jiao Li,Min Wang,Chen Qiu,Qi Yang,Xu-Bo Li,Yun-Long Huang,Rui Liu,Yu-Mei Wu

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-GABA A Receptor alpha 2/GABRA2 antibody

Western blot - Anti-GABA A Receptor alpha 2/GABRA2 antibody (AB72445)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Specificity

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Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Product protocols

Target data

Publications (24)

Product promise