AB72446

Anti-GABA A Receptor alpha 3/GABRA3 antibody

Name: Anti-GABA A Receptor alpha 3/GABRA3 antibody (ab72446) | Abcam
Brand: Abcam Limited
SKU: AB72446
Price: 525 USD
Availability: InStock

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(8 Publications)

Rabbit Polyclonal GABA A Receptor alpha 3/GABRA3 antibody. Suitable for WB and reacts with Rat samples. Cited in 8 publications.

View Alternative Names

Gabra-3, Gabra3, Gamma-aminobutyric acid receptor subunit alpha-3, GABA(A) receptor subunit alpha-3, GABAAR subunit alpha-3

1 Images

Unknown

Western blot - Anti-GABA A Receptor alpha 3/GABRA3 antibody (AB72446)

All lanes:

Western blot - Anti-GABA A Receptor alpha 3/GABRA3 antibody (ab72446) at 1/1000 dilution

Lane 1:

wild type rat brain lysates

Lane 2:

GABA A Receptor alpha 3/GABRA3 knock out rat brain lysates

Predicted band size: 55 kDa

Observed band size: 55 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Rat

Applications

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000", "WB-species-notes": "<p></p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.5 Constituents: 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, 0.238% HEPES, 0.01% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Alpha subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed : 2153588). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s) (By similarity). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (By similarity). Chloride influx into the postsynaptic neuron following GABAAR opening decreases the neuron ability to generate a new action potential, thereby reducing nerve transmission (By similarity).

See full target information Gabra3

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Publications (8)

Recent publications for all applications. Explore the full list and refine your search

Neural regeneration research 19:1351-1359 PubMed37905885

2023

Vibration-reduced anxiety-like behavior relies on ameliorating abnormalities of the somatosensory cortex and medial prefrontal cortex.

Applications

Unspecified application

Species

Unspecified reactive species

Afzal Misrani,Sidra Tabassum,Tintin Wang,Huixian Huang,Jinxiang Jiang,Hongjun Diao,Yanping Zhao,Zhen Huang,Shaohua Tan,Cheng Long,Li Yang

International journal of molecular sciences 24: PubMed37176165

2023

GABA Receptor β3 Subunit Mutation N328D Heterozygous Knock-in Mice Have Lennox-Gastaut Syndrome.

Applications

Unspecified application

Species

Unspecified reactive species

Gerald Ikemefuna Nwosu,Wangzhen Shen,Kirill Zavalin,Sarah Poliquin,Karishma Randhave,Carson Flamm,Marshall Biven,Katherine Langer,Jing-Qiong Kang

IBRO neuroscience reports 13:187-197 PubMed36093283

2022

Grape seed extract suppresses calcitonin gene-related peptide secretion and upregulates expression of GAD 65/67 and GABAB receptor in primary trigeminal ganglion cultures.

Applications

Unspecified application

Species

Unspecified reactive species

Sophia R Antonopoulos,Paul L Durham

The Journal of clinical investigation 130:6555-6570 PubMed32841213

2020

dmPFC-vlPAG projection neurons contribute to pain threshold maintenance and antianxiety behaviors.

Applications

Unspecified application

Species

Unspecified reactive species

Jun-Bin Yin,Shao-Hua Liang,Fei Li,Wen-Jun Zhao,Yang Bai,Yi Sun,Zhen-Yu Wu,Tan Ding,Yan Sun,Hai-Xia Liu,Ya-Cheng Lu,Ting Zhang,Jing Huang,Tao Chen,Hui Li,Zhou-Feng Chen,Jing Cao,Rui Ren,Ya-Nan Peng,Juan Yang,Wei-Dong Zang,Xiang Li,Yu-Lin Dong,Yun-Qing Li

Molecular neurobiology 57:4978-4988 PubMed32820460

2020

Layers II/III of Prefrontal Cortex in Df(h22q11)/+ Mouse Model of the 22q11.2 Deletion Display Loss of Parvalbumin Interneurons and Modulation of Neuronal Morphology and Excitability.

Applications

Unspecified application

Species

Unspecified reactive species

Abdel-Rahman Al-Absi,Per Qvist,Samora Okujeni,Ahmad Raza Khan,Simon Glerup,Connie Sanchez,Jens R Nyengaard

Molecular cancer 16:167 PubMed29078789

2017

miR-92b-3p acts as a tumor suppressor by targeting Gabra3 in pancreatic cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Manmei Long,Ming Zhan,Sunwang Xu,Ruimeng Yang,Wei Chen,Shilei Zhang,Yongheng Shi,Qiao He,Man Mohan,Qiang Liu,Jian Wang

Scientific reports 6:35659 PubMed27767042

2016

Oxytocin modulates GABAR subunits to confer neuroprotection in stroke in vitro.

Applications

Species

Rat

Yuji Kaneko,Colleen Pappas,Naoki Tajiri,Cesar V Borlongan

Neuroscience 273:52-64 PubMed24836856

2014

Reduced CHRNA7 expression in C3H mice is associated with increases in hippocampal parvalbumin and glutamate decarboxylase-67 (GAD67) as well as altered levels of GABA(A) receptor subunits.

Applications

Unspecified application

Species

Unspecified reactive species

R C Bates,B J Stith,K E Stevens,C E Adams

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-GABA A Receptor alpha 3/GABRA3 antibody

Western blot - Anti-GABA A Receptor alpha 3/GABRA3 antibody (AB72446)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

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Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Product protocols

Target data

Publications (8)

Product promise