Rabbit Polyclonal GABA B Receptor 2/GABBR2 antibody. Suitable for WB, IHC-FoFr and reacts with Human, Rat samples. Cited in 8 publications. Immunogen corresponding to Synthetic Peptide within Human GABBR2.
Images
Publications
Filter by
- Frontiers in nutrition 9:8742542022A Novel Theanine Complex, Mg-L-Theanine Improves Sleep Quality Regulating Brain Electrochemical Activity.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMuhammed Furkan Dasdelen,Sezgin Er,Berkan Kaplan,Suleyman Celik,Mustafa Caglar Beker,Cemal Orhan,Mehmet Tuzcu,Nurhan Sahin,Havakhanum Mamedova,Sarah Sylla,James Komorowski,Sara Perez Ojalvo,Kazim Sahin,Ertugrul KilicPubMed 35449538
- Journal of pain research 13:2113-21242020Long Noncoding RNA H19 Induces Neuropathic Pain by Upregulating Cyclin-Dependent Kinase 5-Mediated Phosphorylation of cAMP Response Element Binding Protein.Applications:Unspecified applicationReactive species:Unspecified reactive speciesKai Li et. al.PubMed 32903807
- Stem cell research & therapy 10:1832019Co-administration of human adipose-derived stem cells and low-level laser to alleviate neuropathic pain after experimental spinal cord injury.Applications:Unspecified applicationReactive species:Unspecified reactive speciesArash Sarveazad et. al.PubMed 31234929
- Scientific reports 9:45122019Jujuboside A prevents sleep loss-induced disturbance of hippocampal neuronal excitability and memory impairment in young APP/PS1 mice.Applications:Unspecified applicationReactive species:Unspecified reactive speciesSidra Tabassum et. al.PubMed 30872728
- British journal of pharmacology 176:297-3162018Metformin produces anxiolytic-like effects in rats by facilitating GABA receptor trafficking to membrane.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJun Fan,Di Li,Hong-Sheng Chen,Jian-Geng Huang,Jun-Feng Xu,Wen-Wen Zhu,Jian-Guo Chen,Fang WangPubMed 30318707
- Gene 664:90-1002018Validation and bioinformatic analysis of propofol-induced differentially expressed microRNAs in primary cultured neural stem cells.
- Drug metabolism and disposition: the biological fate of chemicals 46:53-652017Low Cerebral Exposure Cannot Hinder the Neuroprotective Effects of Panax Notoginsenosides.Applications:Unspecified applicationReactive species:Unspecified reactive speciesHaofeng Li,Jingcheng Xiao,Xinuo Li,Huimin Chen,Dian Kang,Yuhao Shao,Boyu Shen,Zhangpei Zhu,Xiaoxi Yin,Lin Xie,Guangji Wang,Yan LiangPubMed 29061584
- PloS one 9:e912972014Molecular mechanisms underlying the enhanced analgesic effect of oxycodone compared to morphine in chemotherapy-induced neuropathic pain.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Human GABBR2. The exact immunogen used to generate this antibody is proprietary information. Database link O75899
Consider this alternative
Reactivity data
Select an application| WB | IHC-FoFr | |
|---|---|---|
| Human | Tested | Expected |
| Rat | Expected | Tested |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/300 - 1/1000 | Notes - |
ExpectedExpected
| Species | Dilution info | Notes |
|---|---|---|
Species Rat | Dilution info Use at an assay dependent concentration. | Notes - |
IHC-FoFr
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Rat | Dilution info - | Notes - |
ExpectedExpected
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info Use at an assay dependent concentration. | Notes - |
Associated Products
Select an associated product type
4 products for Alternative Product
Target data
Function
Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2 (PubMed:15617512, PubMed:18165688, PubMed:22660477, PubMed:24305054, PubMed:9872316, PubMed:9872744). Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins (PubMed:18165688). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase (PubMed:10075644, PubMed:10773016, PubMed:24305054). Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis (PubMed:10075644, PubMed:10773016, PubMed:10906333, PubMed:9872744). Plays a critical role in the fine-tuning of inhibitory synaptic transmission (PubMed:22660477, PubMed:9872744). Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials (PubMed:10075644, PubMed:22660477, PubMed:9872316, PubMed:9872744). Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception (Probable).
Alternative names
GPR51, GPRC3B, GABBR2, Gamma-aminobutyric acid type B receptor subunit 2, GABA-B receptor 2, GABA-B-R2, GABA-BR2, GABABR2, Gb2, G-protein coupled receptor 51, HG20
Recommended products
Rabbit Polyclonal GABA B Receptor 2/GABBR2 antibody. Suitable for WB, IHC-FoFr and reacts with Human, Rat samples. Cited in 8 publications. Immunogen corresponding to Synthetic Peptide within Human GABBR2.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Human GABBR2. The exact immunogen used to generate this antibody is proprietary information. Database link O75899
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Storage information
- Stable for 12 months at -20°C
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
2 product images
Western blot - Anti-GABA B Receptor 2/GABBR2 antibody (ab52248)
All lanes: Western blot - Anti-GABA B Receptor 2/GABBR2 antibody (ab52248) at 1/300 dilution
Lane 1: HeLa cell extract; without peptide
Lane 2: HeLa cell extract; with peptide
Predicted band size: 106 kDa
Observed band size: 106 kDa
This image is courtesy of Karine Thibault, CNRS, Paris, FranceImmunohistochemistry (PFA perfusion fixed frozen sections) - Anti-GABA B Receptor 2/GABBR2 antibody (ab52248)
Immunohistochemistical detection of GABA B Receptor 2/GABBR2 antibody (ab52248) in PFA fixed Rat Dorsal root ganglion sections. ab52248 was used at 1/300 and incubated for 60 hours @ 4°C in PBS-T 0.3%. Secondary antibody: anti IgG Rabbit Conjugation: Alexa Fluor® 488 (1/1000).
Downloads
Product protocols
- Visit the general protocols
- Visit troubleshooting
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com