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AB209717

Anti-gad1b antibody

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(1 Publication)

Rabbit Polyclonal GAD67 antibody. Suitable for IHC - Wmt, WB and reacts with Zebrafish samples. Cited in 1 publication.
2 Images
IHC - Wholemount - Anti-gad1b antibody (AB209717)
  • IHC - Wmt

Supplier Data

IHC - Wholemount - Anti-gad1b antibody (AB209717)

Whole mount immunohistochemical analysis of 2 days post-fertilization zebrafish embryo labeling gad1b with ab209717 at 1/50 dilution.

Western blot - Anti-gad1b antibody (AB209717)
  • WB

Supplier Data

Western blot - Anti-gad1b antibody (AB209717)

Samples were separated by 7.5% SDS-PAGE.

All lanes:

Western blot - Anti-gad1b antibody (ab209717) at 1/500 dilution

All lanes:

Zebrafish brain tissue lysates at 30 µg

Secondary

All lanes:

HRP conjugated anti rabbit IgG antibody

Predicted band size: 57 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Zebrafish

Applications

WB, IHC - Wmt

applications

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Secondary Antibodies

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AB183999

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  • 5
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCWmt" : {"fullname" : "IHC - Wholemount", "shortname":"IHC - Wmt"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Zebrafish": { "IHCWmt-species-checked": "testedAndGuaranteed", "IHCWmt-species-dilution-info": "1/50 - 1/500", "IHCWmt-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle|Store undiluted
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

GAD1b often simply referred to as GAD1 or glutamate decarboxylase 1 is an enzyme that catalyzes the conversion of glutamate to gamma-aminobutyric acid (GABA). This enzyme is a part of the GAD family and has a molecular mass of approximately 67 kDa. GAD1b is primarily expressed in the brain particularly within neurons in the cortex and hippocampus where it plays an essential role in neurotransmitter regulation. This expression is important for maintaining the balance between excitatory and inhibitory signals in the nervous system.
Biological function summary

Glutamate decarboxylase 1 functions as an important regulator of the inhibitory neurotransmitter GABA. GAD1b exists as part of a functional enzyme complex which is involved in neurotransmitter synthesis. This enzymatic activity is fundamental to inhibitory signal transmission and synaptic plasticity which are essential processes for cognitive functions such as learning and memory.

Pathways

Glutamate decarboxylase 1 is an important component in the GABAergic signaling pathway. This pathway involves neurotransmitter production synaptic vesicle release and receptor binding which significantly affects neuronal excitability and mood regulation. GAD1b is linked with other proteins such as GAD2 and various GABA receptor subunits which collectively modulate synaptic inhibition across different brain regions.

Disruptions in GAD1b expression or function can lead to neurological conditions like epilepsy and schizophrenia. These disorders often involve an imbalance in excitatory and inhibitory neurotransmission highlighting the importance of GAD1b's role in producing GABA. Other proteins including GAD2 also play a role in these diseases often contributing to the underlying pathology through their participation in GABA synthesis and regulation pathways.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information gad1b
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Biology 14: PubMed40906377

2025

Functional Spermatogenesis Across Testicular Developmental Stages in Neomale Large Yellow Croaker () Revealed by Histology and Gonadal Specific Cellular Markers.

Applications

Unspecified application

Species

Unspecified reactive species

Xu Liu,Weihua Hu,Ruiyi Chen,Yang Yang,Sixian Yang,Dongdong Xu
View all publications
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Product promise

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