Rabbit Polyclonal GAD67 antibody. Suitable for IHC - Wmt, WB, IHC-P and reacts with Zebrafish samples.
IgG
Rabbit
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Liquid
Polyclonal
IHC - Wmt | WB | IHC-P | |
---|---|---|---|
Zebrafish | Tested | Tested | Tested |
Species | Dilution info | Notes |
---|---|---|
Species Zebrafish | Dilution info 1/50 - 1/500 | Notes - |
Species | Dilution info | Notes |
---|---|---|
Species Zebrafish | Dilution info 1/500 - 1/3000 | Notes - |
Species | Dilution info | Notes |
---|---|---|
Species Zebrafish | Dilution info 1/100 - 1/1000 | Notes - |
Rabbit Polyclonal GAD67 antibody. Suitable for IHC - Wmt, WB, IHC-P and reacts with Zebrafish samples.
IgG
Rabbit
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Liquid
Polyclonal
Affinity purification Immunogen
Blue Ice
1-2 weeks
+4°C
-20°C
Upon delivery aliquot
Avoid freeze / thaw cycle, Store undiluted
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This supplementary information is collated from multiple sources and compiled automatically.
GAD1b often simply referred to as GAD1 or glutamate decarboxylase 1 is an enzyme that catalyzes the conversion of glutamate to gamma-aminobutyric acid (GABA). This enzyme is a part of the GAD family and has a molecular mass of approximately 67 kDa. GAD1b is primarily expressed in the brain particularly within neurons in the cortex and hippocampus where it plays an essential role in neurotransmitter regulation. This expression is important for maintaining the balance between excitatory and inhibitory signals in the nervous system.
Glutamate decarboxylase 1 functions as an important regulator of the inhibitory neurotransmitter GABA. GAD1b exists as part of a functional enzyme complex which is involved in neurotransmitter synthesis. This enzymatic activity is fundamental to inhibitory signal transmission and synaptic plasticity which are essential processes for cognitive functions such as learning and memory.
Glutamate decarboxylase 1 is an important component in the GABAergic signaling pathway. This pathway involves neurotransmitter production synaptic vesicle release and receptor binding which significantly affects neuronal excitability and mood regulation. GAD1b is linked with other proteins such as GAD2 and various GABA receptor subunits which collectively modulate synaptic inhibition across different brain regions.
Disruptions in GAD1b expression or function can lead to neurological conditions like epilepsy and schizophrenia. These disorders often involve an imbalance in excitatory and inhibitory neurotransmission highlighting the importance of GAD1b's role in producing GABA. Other proteins including GAD2 also play a role in these diseases often contributing to the underlying pathology through their participation in GABA synthesis and regulation pathways.
We have tested this species and application combination and it works. It is covered by our product promise.
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
We do not recommend this combination. It is not covered by our product promise.
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Terms & Conditions.
7.5% SDS PAGE
All lanes: Western blot - Anti-gad1b antibody (ab209717) at 1/500 dilution
All lanes: Zebrafish brain whole cell lysate at 30 µg
Predicted band size: 56 kDa
Whole mount immunohistochemical analysis of 2 days post-fertilization zebrafish embryo labeling gad1b with ab209717 at 1/50 dilution.
Whole mount immunohistochemical analysis of 2 days post-fertilization zebrafish embryo labeling gad1b with ab209717 at 1/50 dilution.
Immunohistochemical analysis of paraffin-embedded Zebrafish tissue labeling gad1b with ab209717 at 1/300 dilution.
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