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AB218411

Anti-Galectin 13/PLAC8 antibody [PP13/1161]

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(3 Publications)

Mouse Monoclonal Galectin 13/PLAC8 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human LGALS13 aa 1 to C-terminus.

View Alternative Names

PLAC8, LGALS13, Galactoside-binding soluble lectin 13, Galectin-13, Placental tissue protein 13, Gal-13, PP13, Placental protein 13

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Galectin 13/PLAC8 antibody [PP13/1161] (AB218411)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Galectin 13/PLAC8 antibody [PP13/1161] (AB218411)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded human placenta tissue labeling Galectin 13/PLAC8 with ab218411 at 1 μg/ml.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Galectin 13/PLAC8 antibody [PP13/1161] (AB218411)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Galectin 13/PLAC8 antibody [PP13/1161] (AB218411)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded human spleen tissue labeling Galectin 13/PLAC8 with ab218411 at 1 μg/ml.

Western blot - Anti-Galectin 13/PLAC8 antibody [PP13/1161] (AB218411)
  • WB

Supplier Data

Western blot - Anti-Galectin 13/PLAC8 antibody [PP13/1161] (AB218411)

All lanes:

Western blot - Anti-Galectin 13/PLAC8 antibody [PP13/1161] (ab218411) at 1 µg/mL

Lane 1:

Recombinant human Galectin 13/PLAC8 fragment

Lane 2:

K562 cell lysate

Predicted band size: 16 kDa

false

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

PP13/1161

Isotype

IgG2b

Light chain type

kappa

Carrier free

No

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human LGALS13 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q9UHV8

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1-2 µg/mL", "IHCP-species-notes": "<p>Primary incubation for 30 minutes at room temperature.</p> Perform heat-mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol." } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.2 - 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 0.05% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Galectin 13 also known as placenta-specific 8 protein (PLAC8) is a member of the galectin family. This protein typically has a molecular weight of around 16 kDa. It displays a strong expression in placental tissues and plays a role in the regulation of immune functions. Galectin 13 is secreted in a glycosylation-dependent manner. The protein is involved in cellular recognition and adhesion processes influencing how cells interact with their surrounding environment.
Biological function summary

Galectin 13 aligns itself with key processes in immune response modulation and tissue remodeling. Although it is not known to be a part of a large protein complex its interactions within the extracellular matrix provide vital insights into its function. Galectin 13 promotes apoptotic pathways in various types of immune cells contributing to fetal-maternal tolerance during pregnancy. By controlling trophoblast differentiation and invasion it ensures proper embryo implantation and placental development.

Pathways

Several cellular mechanisms involve Galectin 13 as a principal actor. It plays a role in apoptotic pathways specifically those important for maintaining homeostasis during pregnancy. Galectin 13 interacts with proteins like Bcl-2 family members which are known to regulate cell death. It also associates with immune surveillance mechanisms ensuring the maternal immune system does not reject the developing embryo.

Altered Galectin 13 expression connects to pregnancy-related complications. Conditions like preeclampsia and gestational trophoblastic diseases demonstrate links to the dysregulation of Galectin 13. These disorders often involve other proteins such as HIF-1α and VEGF highlighting its significance in placental function and vascular health. Understanding Galectin 13's role in these contexts can offer further insights into therapeutic approaches.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Binds beta-galactoside and lactose. Strong inducer of T-cell apoptosis (PubMed : 10527825, PubMed : 19497882). Has hemagglutinating activity towards chicken erythrocytes (PubMed : 29343868).
See full target information LGALS13
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Biomedical reports 23:111 PubMed40386306

2025

Notch signaling pathway regulates the progression of fetal growth restriction through mediating immune dysfunction.

Applications

Unspecified application

Species

Unspecified reactive species

Liyan Ye,Xiujuan Zheng,Yali Yang,Ying Lyu

Medicina (Kaunas, Lithuania) 60: PubMed39064506

2024

Placental Protein 13 and Syncytiotrophoblast Basement Membrane Ultrastructures in Preeclampsia.

Applications

Unspecified application

Species

Unspecified reactive species

Peby Maulina Lestari,Noroyono Wibowo,Damar Prasmusinto,Muhammad Yamin,Nuryati Chairani Siregar,Joedo Prihartono,Ina Susianti Timan,Johanes C Mose,Iche Andriyani Liberty,Cindy Kesty,Bella Stevanny

BioMed research international 2018:7364539 PubMed29750170

2018

Electroporation with Cisplatin against Metastatic Pancreatic Cancer: Study on Human Primary Cell Culture.

Applications

Unspecified application

Species

Unspecified reactive species

Olga Michel,Julita Kulbacka,Jolanta Saczko,Justyna Mączyńska,Piotr Błasiak,Joanna Rossowska,Adam Rzechonek
View all publications
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