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AB106471

Anti-GALNT10 antibody

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(1 Publication)

Rabbit Polyclonal GALNT10 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human Polypeptide N-acetylgalactosaminyltransferase 10.

View Alternative Names

Polypeptide N-acetylgalactosaminyltransferase 10, Polypeptide GalNAc transferase 10, Protein-UDP acetylgalactosaminyltransferase 10, UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 10, GalNAc-T10, pp-GaNTase 10, GALNT10

3 Images
Immunocytochemistry/ Immunofluorescence - Anti-GALNT10 antibody (AB106471)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-GALNT10 antibody (AB106471)

Immunofluorescence of GALNT10 in Human Brain cells using ab106471 at 20 ug/ml.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GALNT10 antibody (AB106471)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GALNT10 antibody (AB106471)

ab106471, at 2.5 µg/ml, staining GALNT10 in Human brain tissue by Immunohistochemistry.

Western blot - Anti-GALNT10 antibody (AB106471)
  • WB

Unknown

Western blot - Anti-GALNT10 antibody (AB106471)

Lane 1:

Western blot - Anti-GALNT10 antibody (ab106471) at 1 µg/mL

Lane 2:

Western blot - Anti-GALNT10 antibody (ab106471) at 2 µg/mL

All lanes:

SK-N-SH cell lysate at 15 µg

Predicted band size: 68 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF, IHC-P, WB

applications

Immunogen

Synthetic Peptide within Human Polypeptide N-acetylgalactosaminyltransferase 10. The exact immunogen used to generate this antibody is proprietary information.

Q86SR1

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD20 antibody [SP32] (AB64088)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "2.5 µg/mL", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "20 µg/mL", "ICCIF-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
Up to 12 months
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

GALNT10 also known as polypeptide N-acetylgalactosaminyltransferase 10 is a member of the GalNAc-T family of enzymes. The enzyme plays an important mechanical role by catalyzing the transfer of N-acetylgalactosamine (GalNAc) to serine and threonine residues on proteins a process called O-glycosylation. This enzymatic activity is critical for proper protein modification and function. GALNT10 has a molecular mass of approximately 68 kDa. It is expressed in a variety of tissues notably in the liver which indicates its extensive role in protein processing within this organ.
Biological function summary

Polypeptide N-acetylgalactosaminyltransferase 10 influences the initial steps of mucin-type O-glycosylation which significantly affects protein stability and cell signaling. It is not part of a large enzyme complex but its function is integral to the regulation of substrate-specific modifications. This protein aids in the modulation of various glycoproteins impacting diverse physiological processes. Alterations in its activity potentially lead to changes in cell-cell interactions and mucosal protection.

Pathways

GALNT10 is involved in O-glycan biosynthetic pathways where its role is pivotal in glycan structure formation and diversity. This pathway enables the proper glycosylation of proteins that are essential for cell-cell communication and adhesion. GALNT10's activity relates closely to other glycosyltransferases within this pathway including GALNT1 reflecting its cooperative nature within glycosylation networks. Moreover it supports the broader glycosylation landscape by influencing the availability of glycosylation sites on various protein substrates.

GALNT10 has associations with specific conditions such as cancers and metabolic syndromes. Abnormal function or expression of this enzyme can contribute to tumorigenesis due to its influence on glycosylation patterns that affect cell adhesion and signaling. The enzyme is also linked to liver disorders arising from its high expression in liver tissue and its impact on protein processing. In the context of cancer GALNT10’s interactions with similar glycosylation enzymes like GALNT3 illustrate its role in modifying glycan structures which are critical for cellular transformation and cancer progression.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward Muc5Ac and EA2 peptide substrates.
See full target information Polypeptide N-acetylgalactosaminyltransferase 10
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Evidence-based complementary and alternative medic 2018:1293630 PubMed30643524

2018

GZFLW Induces Apoptosis of Ectopic Endometrial Stromal Cells via Promoting VPS53 Protein Stability.

Applications

Unspecified application

Species

Unspecified reactive species

Ziyu Zhang,Faying Liu,YunYun Xu,Huang Huang,Yang Zou,Bicheng Yang,Yong Luo,Quan Zhang,Anwen Xiong,Liqun Wang,Ouping Huang
View all publications
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Product promise

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