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AB122149

Anti-GALNTL6 antibody

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(1 Publication)

Rabbit Polyclonal GALNTL6 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human GALNTL6 aa 1-150.

View Alternative Names

GALNT17, GALNTL6, Polypeptide N-acetylgalactosaminyltransferase-like 6, Polypeptide GalNAc transferase 17, Protein-UDP acetylgalactosaminyltransferase 17, Putative polypeptide N-acetylgalactosaminyltransferase 17, UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 17, GalNAc-T17, pp-GaNTase 17

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GALNTL6 antibody (AB122149)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GALNTL6 antibody (AB122149)

ab122149, at 1/135, staining GALNTL6 in paraffin-embedded Human placenta tissue by Immunohistochemistry.

Western blot - Anti-GALNTL6 antibody (AB122149)
  • WB

Unknown

Western blot - Anti-GALNTL6 antibody (AB122149)

All lanes:

Western blot - Anti-GALNTL6 antibody (ab122149) at 1/250 dilution

Lane 1:

RT-4 cell lysate

Lane 2:

U-251 MG cell lysate

Lane 3:

Human Plasma

Lane 4:

Human Liver lysate

Lane 5:

Human Tonsil lysate

Predicted band size: 70 kDa

true

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human GALNTL6 aa 1-150. The exact immunogen used to generate this antibody is proprietary information.

Q49A17

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

GALNTL6 also known as Polypeptide N-acetylgalactosaminyltransferase-like protein 6 is an enzyme responsible for catalyzing the initial step of O-linked glycosylation. It transfers N-acetylgalactosamine (GalNAc) to serine and threonine residues of proteins. The molecular mass of GALNTL6 is approximately 72 kDa. Its expression is observed in several tissues including the brain and reproductive organs suggesting tissue-specific roles.
Biological function summary

GALNTL6 contributes to the regulation of protein glycosylation which impacts protein folding stability and signaling functions. It does not appear to be a part of a larger protein complex but functions as an individual glycosyltransferase enzyme. Through its glycosylating activities GALNTL6 influences cell-cell communication and adhesion processes especially within the cellular matrix.

Pathways

GALNTL6 plays a role in the biosynthetic pathway of O-linked glycan synthesis significantly affecting mucin-type O-glycosylation pathways. It relates to proteins such as mucins a family of high molecular weight heavily glycosylated proteins that play pivotal roles in forming protective mucous barriers. These processes are important for maintaining healthy epithelial surfaces and modulating interactions between cells and their environment.

Aberrant glycosylation involving GALNTL6 has been linked to several conditions. Changes in its function or expression may contribute to disorders such as colorectal cancer and polycystic ovary syndrome (PCOS). In these disorders GALNTL6 is connected to alterations in other glycosylation-related proteins including MUC1 which is known to have altered glycosylation patterns in tumour progression and cancer metastasis. Understanding GALNTL6's involvement in these diseases could inform potential therapeutic strategies.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor.
See full target information GALNTL6
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

International journal of molecular sciences 25: PubMed38203580

2024

YB-1 Is a Novel Target for the Inhibition of α-Adrenergic-Induced Hypertrophy.

Applications

Unspecified application

Species

Unspecified reactive species

Jacqueline Heger,Stefan Partsch,Claudia Harjung,Zoltán V Varga,Tamás Baranyai,Johannes Weiß,Lea Kremer,Fabian Locquet,Przemyslaw Leszek,Bence Ágg,Bettina Benczik,Péter Ferdinandy,Rainer Schulz,Gerhild Euler
View all publications
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Product promise

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