AB170923

Anti-GALP antibody [EPR10528]

RabMAb
Recombinant
What is this?

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(2 Publications)

Rabbit Recombinant Monoclonal GALP antibody. Suitable for WB and reacts with Recombinant full length protein samples. Cited in 2 publications.

View Alternative Names

Galanin-like peptide, GALP

1 Images

Supplier Data

Western blot - Anti-GALP antibody [EPR10528] (AB170923)

All lanes:

Western blot - Anti-GALP antibody [EPR10528] (ab170923) at 1/1000 dilution

All lanes:

GST tagged GALP recombinant protein at 0.01 µg

Secondary

All lanes:

Goat anti-rabbit HRP conjugated antibody at 1/2000 dilution

Predicted band size: 13 kDa

true

Carrier free

Anti-GALP antibody [EPR10528] - BSA and Azide free

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR10528

Isotype

IgG

Carrier free

Applications

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

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Product details

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form

Liquid

Purity

Tissue culture supernatant

Storage buffer

pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

GALP also known as Galanin-like peptide is a neuropeptide involved in various metabolic processes. The protein has a mass of approximately 7.6 kDa. GALP is mainly expressed in the hypothalamus a brain region critical for regulating energy balance and reproductive functions. In addition to the hypothalamus GALP expression occurs in peripheral tissues including the pituitary gland and the testis indicating its broader role in physiological processes.

Biological function summary

GALP functions as a regulatory factor in appetite control and energy balance. It does not operate as part of a larger protein complex but it interacts with galanin receptors. These interactions can modulate neuroendocrine and behavioral responses. GALP plays significant roles in influencing feeding behavior body weight and reproductive hormone release making it important in maintaining homeostasis.

Pathways

GALP is an integral component in the regulation of the neuroendocrine axis and the energy homeostasis pathway. It influences the hypothalamic-pituitary-gonadal axis which impacts reproductive hormone regulation. In these pathways GALP interacts with proteins such as neuropeptide Y and leptin both well-known for their roles in regulating food intake and energy expenditure.

GALP has significant associations with obesity and reproductive dysfunctions. Its interaction with leptin an important regulator in obesity implicates GALP in weight-related disorders. Furthermore dysregulation of GALP can affect hormonal balance potentially leading to reproductive issues. These connections highlight GALP's importance in understanding metabolic and reproductive health challenges.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Isoform 1. Hypothalamic neuropeptide which binds to the G-protein-coupled galanin receptors (GALR1, GALR2 and GALR3). Involved in a large number of putative physiological functions in CNS homeostatic processes, including the regulation of gonadotropin-releasing hormone secretion.. Isoform 2. Exhibits potent and dose-dependent vasoconstrictor and anti-edema activity in the cutaneous microvasculature, a physiologic effects which does not appear to be mediated via GALR1 or GALR2. Exhibits antimicrobial activity against Gram-negative bacterias, inducing bacterial membrane blebbing (PubMed : 23537644).

See full target information GALP

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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

European journal of histochemistry : EJH 68: PubMed39494460

2024

Alarin regulates RyR2 and SERCA2 to improve cardiac function in heart failure with preserved ejection fraction.

Applications

Unspecified application

Species

Unspecified reactive species

Jinshuang Li,Dawei Xu,Ce Shi,Chunqi Cheng,Ziheng Xu,Xingjuan Gao,Yong Cheng

Acta pharmacologica Sinica 45:1951-1963 PubMed38760543

2024

Bevacizumab induces ferroptosis and enhances CD8 T cell immune activity in liver cancer via modulating HAT1 and increasing IL-9.

Applications

Unspecified application

Species

Unspecified reactive species

Chun-Yu Hou,Pan Lv,Hong-Feng Yuan,Li-Na Zhao,Yu-Fei Wang,Hui-Hui Zhang,Guang Yang,Xiao-Dong Zhang

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-GALP antibody [EPR10528]

Western blot - Anti-GALP antibody [EPR10528] (AB170923)

Related conjugates and formulations (1)

Key facts

Host species

Clonality

Clone number

Isotype

Carrier free

Applications

Immunogen

Reactivity data

Product details

Properties and storage information

Form

Purity

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (2)

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Product promise