Anti-GALR1 antibody - C-terminal

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

GALR1 also known as Galanin Receptor 1 is a protein encoded by the GALR1 gene. This receptor has an approximate mass of 37 kDa and belongs to the G protein-coupled receptor (GPCR) family. It is widely expressed in the central nervous system particularly in hippocampus hypothalamus and cortex regions. Additionally GALR1 expression can be found in peripheral tissues like the gastrointestinal tract and pancreas.

Biological function summary

GALR1 plays a role in mediating the effects of the neuropeptide galanin acting as a receptor that activates intracellular pathways upon binding. Although not part of a protein complex GALR1 interacts with G-proteins inside the cell initiating a cascade that influences neuronal excitability and neurotransmitter release. Its function contributes significantly to the modulation of various physiological processes such as pain mood and feeding behavior.

Pathways

GALR1 is involved in the regulation of the PI3K/AKT signaling pathway and the MAPK/ERK pathway both critical for cellular functions like survival and proliferation. GALR1 interaction with galanin and the subsequent involvement of G-proteins link it to these pathways showing interconnectedness with proteins like PI3K and ERK. These interactions highlight GALR1's important role in signal transduction mechanisms.

Associated diseases and disorders

GALR1 has links to conditions such as epilepsy and depression. Research implicates abnormal signaling through GALR1 and its pathways in contributing to the pathophysiology of these disorders. In epilepsy altered GALR1 expression might influence seizure susceptibility while in depression disrupted galanin-GALR1 interactions can affect mood regulation. GALR1's association with these conditions often involves related proteins like G-proteins and other galanin receptors indicating its potential as a therapeutic target.