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AB150486

Anti-GALR1 antibody - C-terminal

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(2 Publications)

Rabbit Polyclonal GALR1 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human GALR1.

View Alternative Names

GALNR, GALNR1, GALR1, Galanin receptor type 1, GAL1-R, GALR-1

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GALR1 antibody - C-terminal (AB150486)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GALR1 antibody - C-terminal (AB150486)

Immunohistochemical analysis of paraffin embedded Human brain tissue labelling GALR1 with ab150486 antibody at a concentration of 7 µg/ml.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human GALR1. The exact immunogen used to generate this antibody is proprietary information.

P47211

Specificity

BLAST analysis of the peptide immunogen showed no homology with other Human proteins.

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GALR2 antibody (AB203072)

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InstantBlue® Coomassie Protein Stain (ISB1L)

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Primary Antibodies

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GLRA2 antibody (AB97628)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "7 µg/mL", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval before commencing with IHC staining protocol." }, "Chimpanzee": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Gorilla": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Orangutan": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.1% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

GALR1 also known as Galanin Receptor 1 is a protein encoded by the GALR1 gene. This receptor has an approximate mass of 37 kDa and belongs to the G protein-coupled receptor (GPCR) family. It is widely expressed in the central nervous system particularly in hippocampus hypothalamus and cortex regions. Additionally GALR1 expression can be found in peripheral tissues like the gastrointestinal tract and pancreas.
Biological function summary

GALR1 plays a role in mediating the effects of the neuropeptide galanin acting as a receptor that activates intracellular pathways upon binding. Although not part of a protein complex GALR1 interacts with G-proteins inside the cell initiating a cascade that influences neuronal excitability and neurotransmitter release. Its function contributes significantly to the modulation of various physiological processes such as pain mood and feeding behavior.

Pathways

GALR1 is involved in the regulation of the PI3K/AKT signaling pathway and the MAPK/ERK pathway both critical for cellular functions like survival and proliferation. GALR1 interaction with galanin and the subsequent involvement of G-proteins link it to these pathways showing interconnectedness with proteins like PI3K and ERK. These interactions highlight GALR1's important role in signal transduction mechanisms.

GALR1 has links to conditions such as epilepsy and depression. Research implicates abnormal signaling through GALR1 and its pathways in contributing to the pathophysiology of these disorders. In epilepsy altered GALR1 expression might influence seizure susceptibility while in depression disrupted galanin-GALR1 interactions can affect mood regulation. GALR1's association with these conditions often involves related proteins like G-proteins and other galanin receptors indicating its potential as a therapeutic target.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Receptor for the hormone galanin. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity.
See full target information GALR1
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Biology 12: PubMed37998017

2023

Acetylcholine, Another Factor in Breast Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Juan P Muñoz,Gloria M Calaf

Frontiers in oncology 12:877147 PubMed35707368

2022

Evaluation of Galanin Expression in Colorectal Cancer: An Immunohistochemical and Transcriptomic Study.

Applications

Unspecified application

Species

Unspecified reactive species

Iman M Talaat,Nada M Yakout,Ahmed S A Soliman,Thenmozhi Venkatachalam,Arya Vinod,Leen Eldohaji,Vidhya Nair,Amal Hareedy,Alaa Kandil,Wael M Abdel-Rahman,Rifat Hamoudi,Maha Saber-Ayad
View all publications
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Product promise

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