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AB203072

Anti-GALR2 antibody

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(1 Publication)

Rabbit Polyclonal GALR2 antibody. Suitable for WB, IHC-P and reacts with Mouse, Rat samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human GALR2 aa 50-100 conjugated to Keyhole Limpet Haemocyanin.
2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GALR2 antibody (AB203072)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GALR2 antibody (AB203072)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded Rat brain labeling GALR2 with ab203072 at 1/200 dilution followed by conjugation to the secondary antibody and DAB staining.

Western blot - Anti-GALR2 antibody (AB203072)
  • WB

Supplier Data

Western blot - Anti-GALR2 antibody (AB203072)

All lanes:

Western blot - Anti-GALR2 antibody (ab203072) at 1/200 dilution

All lanes:

Mouse brain lysate

Secondary

All lanes:

HRP conjugated secondary antibody for 90 min at 37˚C at 1/3000 dilution

Predicted band size: 42 kDa

Observed band size: 42 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Rat

Applications

IHC-P, WB

applications

Immunogen

Synthetic Peptide within Human GALR2 aa 50-100 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

O43603

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Galanin antibody [EPR22496-308] (AB254556)

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Primary Antibodies

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Primary Antibodies

AB150486

Anti-GALR1 antibody - C-terminal

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GALR1 antibody - C-terminal (AB150486)

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Primary Antibodies

AB319045

Anti-Dynorphin A antibody [EPR28632-17]

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Dynorphin A antibody [EPR28632-17] (AB319045)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/100 - 1/1000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "<p>(or 1/50 - 1/200 using a fluorescent secondary antibody)</p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Preservative: 0.02% Proclin 300 Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

GALR2 also known as Galanin receptor type 2 is a G protein-coupled receptor with a molecular mass of around 38 kDa. This receptor is expressed in several tissues including the central nervous system peripheral nervous system and various peripheral organs. GALR2 interacts with the neuropeptide galanin which modulates several physiological functions. The receptor signals through different classes of G proteins leading to the activation of intracellular second messengers.
Biological function summary

GALR2 influences numerous processes essential for maintaining homeostasis. It mediates cellular responses to stress appetite and mood through interaction with its ligand galanin. Though GALR2 does not form part of a larger receptor complex it plays a central role in its signaling pathways. Researchers recognize its function in promoting neurogenesis and modulating neurotransmitter release impacting several neural circuits.

Pathways

GALR2 plays roles in the MAPK/ERK pathway and the PI3K/AKT pathway. These pathways are essential for cell survival differentiation and proliferation. GALR2 interacts closely with other receptors such as GALR1 and GALR3 sharing similar downstream effects while maintaining distinct cellular responses. Such interactions help coordinate various physiological functions like memory and feeding behavior.

GALR2 has associations with depression and epilepsy. The receptor's modulation of mood regulation links it to depressive disorders while its influence on neurotransmitter release affects epilepsy-related pathways. In these conditions GALR2 often works with other galanin receptors particularly GALR1 to mechanisms that underpin neural dysfunction and resilience. Understanding its roles provides insight into potential therapeutic targets for managing these disorders.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Receptor for the hormone galanin and GALP. Receptor for the hormone spexin-1 (PubMed : 24517231). The activity of this receptor is mediated by G proteins that activate the phospholipase C/protein kinase C pathway (via G(q)) and that inhibit adenylyl cyclase (via G(i)).
See full target information GALR2

Alternative Names

GALNR2, GALR2, Galanin receptor type 2, GAL2-R, GALR-2
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Publications (1)

Recent publications for all applications. Explore the full listand refine your search

Scientific reports 7:45930 PubMed28378856

2017

Involvement of galanin and galanin receptor 2 in nociceptive modulation in anterior cingulate cortex of normal rats and rats with mononeuropathy.

Applications

Unspecified application

Species

Unspecified reactive species

Meng-Lin Zhang,Hong-Bo Wang,Feng-Hua Fu,Long-Chuan Yu
View all publications
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Product promise

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