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AB190694

Anti-GALR3 antibody [EPR15055] - C-terminal

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(1 Publication)

Rabbit Recombinant Monoclonal GALR3 antibody. C-terminal. Suitable for IP, WB and reacts with Human, Mouse, Rat samples. Cited in 1 publication.

View Alternative Names

GALNR3, GALR3, Galanin receptor type 3, GAL3-R, GALR-3

3 Images
Immunoprecipitation - Anti-GALR3 antibody [EPR15055] - C-terminal (AB190694)
  • IP

Supplier Data

Immunoprecipitation - Anti-GALR3 antibody [EPR15055] - C-terminal (AB190694)

Immunoprecipitation analysis of Human cerebellum tissue lysate labeling GALR3 with ab190694 at 1/50 dilution (lane 1) and a PBS control (lane 2). Secondary staining with anti-Rabbit IgG (HRP), specific to the non-reduced form of IgG antibody at 1/1500 dilution.

All lanes:

Immunoprecipitation - Anti-GALR3 antibody [EPR15055] - C-terminal (ab190694)

Predicted band size: 40 kDa

false

Western blot - Anti-GALR3 antibody [EPR15055] - C-terminal (AB190694)
  • WB

Supplier Data

Western blot - Anti-GALR3 antibody [EPR15055] - C-terminal (AB190694)

All lanes:

Western blot - Anti-GALR3 antibody [EPR15055] - C-terminal (ab190694) at 1/2000 dilution

Lane 1:

Human cerebellum tissue lysate at 20 µg

Lane 2:

Human hippocampus tissue lysate at 20 µg

Secondary

All lanes:

Anti-Rabbit IgG (HRP), specific to the non-reduced form of IgG at 1/1000 dilution

Predicted band size: 40 kDa

false

Western blot - Anti-GALR3 antibody [EPR15055] - C-terminal (AB190694)
  • WB

Supplier Data

Western blot - Anti-GALR3 antibody [EPR15055] - C-terminal (AB190694)

All lanes:

Western blot - Anti-GALR3 antibody [EPR15055] - C-terminal (ab190694) at 1/2000 dilution

Lane 1:

Mouse brain tissue lysate at 10 µg

Lane 2:

Rat brain tissue lysate at 10 µg

Lane 3:

C6 cell lysate at 10 µg

Secondary

All lanes:

Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

Predicted band size: 40 kDa

false

  • Carrier free

    Anti-GALR3 antibody [EPR15055] - BSA and Azide free

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR15055

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Rat, Human

Applications

WB, IP

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Primary Antibodies

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Primary Antibodies

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "testedAndGuaranteed", "IP-species-dilution-info": "1/30", "IP-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/2000", "WB-species-notes": "<p></p>" }, "Mouse": { "IP-species-checked": "guaranteed", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/2000", "WB-species-notes": "<p></p>" }, "Rat": { "IP-species-checked": "guaranteed", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/2000", "WB-species-notes": "<p></p>" } } }
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Product details

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
Shipped at conditions
Conditional Ambient
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

GALR3 also known as Galanin Receptor 3 is a G protein-coupled receptor with a mass of approximately 40 kDa. It is part of the galanin receptor family which consists of three members: GALR1 GALR2 and GALR3 itself. GALR3 is primarily expressed in the central nervous system and certain peripheral tissues. The receptor binds to the neuropeptide galanin and modulates various intracellular signaling pathways including inhibition of adenylate cyclase and modulation of ion channels.
Biological function summary

The interaction of GALR3 with galanin influences numerous physiological processes. GALR3 is not part of a known complex but functions independently to affect neural function. The receptor plays roles in modulating mood cognition and pain perception. It contributes to the regulation of neuroendocrine functions influencing hormone release and feeding behavior. GALR3's expression pattern and signaling capabilities suggest its involvement in fine-tuning nervous system responses.

Pathways

GALR3 is integrated into the neuropeptide signaling pathway and the G-protein signaling pathway. In the neuropeptide signaling pathway its interaction with galanin influences neurotransmitter release and synaptic plasticity. In the context of G-protein signaling GALR3 influences downstream effectors such as PLC and PI3K often working alongside related receptors like GALR1 and GALR2. These interactions reflect GALR3’s contribution to maintaining cellular homeostasis and response to external stimuli.

GALR3 shows relevance to several neuropsychiatric and metabolic conditions. Research indicates that GALR3 may play a role in depression where it modulates neurotransmitter release and synaptic plasticity. Its interaction with proteins like GALR1 and GALR2 is considered important here. Additionally GALR3 presents a connection to obesity due to its involvement in feeding behavior regulation and energy homeostasis. Understanding GALR3's role in these conditions can open avenues for therapeutic interventions targeting this receptor.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Receptor for the hormone galanin (PubMed : 25691535). Receptor for the hormone spexin-1 (PubMed : 24517231).
See full target information GALR3
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Advanced science (Weinheim, Baden-Wurttemberg, Germany) 12:e02838 PubMed40548932

2025

CD74 Blockade Disrupts Endothelial Migrasome Signaling to Prevent Inflammatory Macrophage Differentiation and Inhibit Atherosclerotic Progression.

Applications

Unspecified application

Species

Unspecified reactive species

Kangnan Zhang,Jiong Chen,Zhenhua Zhu,Hong Hu,Qinghui Zhang,Rongrong Jia,Na Wang,Shihao Xiang,Yong Zhou,Yuehong Wang,Ling Xu
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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