Anti-gamma Actin antibody [2A3]

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

Gamma actin also known as actin gamma 1 and actin kDa is an essential actin protein found in the cytoskeleton. It is expressed widely in various tissues including muscle and non-muscle cells. This protein has a molecular mass of approximately 42 kDa. Gamma actin plays a mechanical role in maintaining cellular shape and facilitating cell motility by polymerizing into filamentous structures known as F-actin. It has alternate names such as 2a-3' and actin green in some contexts.

Biological function summary

Gamma actin contributes significantly to the structure of the cytoskeleton affecting cell shape and function. It forms part of actin filament complexes that provide tension and support to the cell. In both muscle and non-muscle cells gamma actin interacts with other actin isoforms to ensure filament stability and elasticity. These interactions are important for processes like cell division signal transduction and cellular transport.

Pathways

Gamma actin is involved in pathways related to cell motility and division. This protein is integral to the actin cytoskeleton pathway and has connections with proteins such as profilin and cofilin which regulate actin filament dynamics. Additionally it plays roles in signal transduction pathways that control cellular responses to external signals working alongside proteins like the Rho GTPases.

Associated diseases and disorders

Gamma actin has been linked to conditions such as deafness and certain types of cancer. Mutations in the ACTG1 gene encoding gamma actin have been associated with hereditary hearing loss. In cancer changes in gamma actin expression can affect cell migration and invasion contributing to tumor progression. The protein's interaction with other actins and related proteins like actin-binding proteins makes it a critical factor in the molecular mechanisms underlying these diseases.