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AB23942

Anti-Ganglioside asialo GM2 antibody

5

(1 Review)

|

(4 Publications)

Rabbit Polyclonal Ganglioside asialo GM2 antibody. Suitable for ELISA, WB, TLC and reacts with Chemical samples. Cited in 4 publications.

View Alternative Names

Asialo GM 2, Asialo GM 2 ganglioside, Ganglioside asialo GM 2

Key facts

Host species

Rabbit

Clonality

Polyclonal

Carrier free

No

Applications

ELISA, WB, TLC

applications

Specificity

No cross-reaction with other carbohydrate epitopes.

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Reactivity data

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Product details

This product is a mix of IgG and IgM.
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Properties and storage information

Form
Liquid
Purity
Whole antiserum
Storage buffer
Constituents: Whole serum
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Ganglioside asialo GM2 also known as GA2 is a biologically active glycolipid mass of approximately 1200 daltons. It typically resides in the outer layer of the plasma membrane of neuronal cells contributing to the structural integrity and functionality of cell membranes. In comparison with ganglioside GM2 asialo GM2 lacks sialic acid which affects its interactions and functions at the cellular level.
Biological function summary

This ganglioside plays an essential role in intercellular recognition and communication by participating in cell adhesion and signaling processes. It functions as part of glycoproduct complexes which impact the formation of signaling domains. These complexes influence synaptic stability and plasticity which are important for the functioning of the nervous system. Due to its structural properties asialo GM2 may also interact with proteins related to signaling pathways.

Pathways

Asialo GM2 influences neural signaling and development pathways. It associates with important cascade reactions including the PI3K/AKT signaling pathway which affects cell survival and metabolism. Additionally it potentially interacts with other glycolipids and proteins like integrins which play parts in cell adhesion and signal transmission. This interaction can modulate how cells respond to extracellular signals and maintain homeostasis.

Asialo GM2 relates notably to autoimmune neuropathies and neurodegenerative diseases. Anti-ganglioside antibodies targeting asialo GM2 may arise in conditions like Guillain-Barré syndrome an acute inflammatory disorder affecting the peripheral nervous system. These antibodies can damage neuronal gangliosides leading to nerve signal disruption. Additionally asialo GM2 may have impacts on the development of other neurodegenerative conditions where it interacts with neuropathy-associated proteins exacerbating disease progressions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information Ganglioside asialo GM2
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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

International journal of biological sciences 21:433-453 PubMed39744431

2025

Ganglioside GA2-mediated caspase-11 activation drives macrophage pyroptosis aggravating intimal hyperplasia after arterial injury.

Applications

Unspecified application

Species

Unspecified reactive species

Yunmin Shi,Tian He,Hong Liu,Xiaodong Li,Zhengxin Li,Qing Wen,Zhaohui Dai,Xuejing Sun,Qian Tan,Wenjing Yang,Youxiang Jiang,Yuanyuan Liu,Hong Yuan,Fang Lei,Yang Yi,Jingjing Cai

Nature communications 15:2553 PubMed38519472

2024

SNX8 enables lysosome reformation and reverses lysosomal storage disorder.

Applications

Unspecified application

Species

Unspecified reactive species

Xinran Li,Cong Xiang,Shilei Zhu,Jiansheng Guo,Chang Liu,Ailian Wang,Jin Cao,Yan Lu,Dante Neculai,Pinglong Xu,Xin-Hua Feng

Heliyon 9:e18082 PubMed37539272

2023

Loss of Flot2 expression in deep cerebellar nuclei neurons of mice with Niemann-Pick disease type C.

Applications

Unspecified application

Species

Unspecified reactive species

Tsu-I Chen,Pei-Chun Hsu,Ni-Chung Lee,Yu-Han Liu,Hao-Chun Wang,Yen-Hsu Lu,Yin-Hsiu Chien,Wuh-Liang Hwu

FASEB journal : official publication of the Federa 22:3617-27 PubMed18591368

2008

Imatinib therapy blocks cerebellar apoptosis and improves neurological symptoms in a mouse model of Niemann-Pick type C disease.

Applications

Unspecified application

Species

Unspecified reactive species

Alejandra R Alvarez,Andrés Klein,Juan Castro,Gonzalo I Cancino,Julio Amigo,Matías Mosqueira,Lina M Vargas,L Fernanda Yévenes,Francisca C Bronfman,Silvana Zanlungo
View all publications
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