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AB134019

Anti-GAP43 antibody

3

(1 Review)

|

(2 Publications)

Chicken Polyclonal GAP43 antibody. Suitable for ICC/IF and reacts with Mouse samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Mouse Gap43 conjugated to Keyhole Limpet Haemocyanin.

View Alternative Names

Basp2, Gap43, Neuromodulin, Axonal membrane protein GAP-43, Calmodulin-binding protein P-57, Growth-associated protein 43

Key facts

Host species

Chicken

Clonality

Polyclonal

Isotype

IgY

Carrier free

No

Reacts with

Mouse

Applications

ICC/IF

applications

Immunogen

Synthetic Peptide within Mouse Gap43 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

P06837

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/1000 - 1/2000", "ICCIF-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
IgY fractions were purified from the yolks
Storage buffer
pH: 7 Preservative: 0.02% Sodium azide Constituents: PBS, 0.5% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

GAP43 commonly called Growth Associated Protein 43 or neuronal marker is a protein with a molecular weight of approximately 25-50 kDa. Researchers identify it by various names including GAP-43 GAP43 anticuerpo or GAP43 neuronal marker. This protein exhibits a specific presence in the nervous system especially in axons of neurons. It has significant expression during neural development and regeneration indicating its role in growth and repair.
Biological function summary

GAP43 plays an important role in neurite outgrowth and synaptic plasticity. It functions as an important mediator of signal transduction in neurons. GAP43 does not act alone but integrates into a network of signaling pathways that guide axonal elongation and branching. It works closely with cytoskeletal elements influencing the structural dynamics needed for effective neuronal response and adaptation.

Pathways

GAP43 is vital in the regulation of the protein kinase C pathway and the cAMP pathway both essential for neuronal growth and differentiation. It closely interacts with proteins such as calmodulin which binds to GAP43 and impacts its function in those pathways. These interactions highlight its role in the modulation of neuronal growth and synaptic plasticity making it essential for neurons' response to environmental signals.

GAP43 associates with neurodegenerative diseases and cognitive disorders particularly Alzheimer's disease and schizophrenia. Changes in GAP43 expression levels correlate with the severity and progression of these conditions. Additionally GAP43 connects to other proteins implicated in such diseases like tau in Alzheimer's suggesting a multifaceted involvement in disease mechanisms. This makes it a target of interest for therapeutic research as modulating GAP43 activity might alter disease progression.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction.
See full target information Gap43
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

iScience 28:113438 PubMed41054506

2025

SARS-CoV-2 infection drives local inflammation of the intestinal epithelium in immunocompromised patients with cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Emil Lou,Christine Luo,Katherine Ladner,Allison Makovec,Phillip Wong,Jeremy Chacon,Eamon Toye,Ella Boytim,Emily Gammon Hawkins,Anthony Patregnani,Emily John,Sanyukta Padmanabhan,Akshat Sarkari,Alison Wong,Julia Stuart,Andrew C Nelson,Brian Betts,Eliseo Eugenin,Justin Hwang

Proceedings of the National Academy of Sciences of 111:2782-7 PubMed24550308

2014

Nuclear compartmentalization of odorant receptor genes.

Applications

ICC/IF

Species

Mouse

Lucia M Armelin-Correa,Luciana M Gutiyama,Débora Y C Brandt,Bettina Malnic
View all publications
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Product promise

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