Rabbit Polyclonal GAP43 antibody. Neural Stem Cell marker. Suitable for IHC-P and reacts with Human samples. Cited in 28 publications. Immunogen corresponding to Native Full Length Protein corresponding to Cat GAP43.
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- Neural regeneration research 18:1976-19822023C-X-C chemokine receptor type 7 antibody enhances neural plasticity after ischemic stroke.Applications:Unspecified applicationReactive species:Unspecified reactive speciesXiao-Qian Zhang,Xiao-Yin Wang,Bing-Chao Dong,Mei-Xuan Li,Yu Wang,Ting Xiao,Shan-Shan ZhaoPubMed 36926722
- PloS one 17:e02771332022Cutaneous expression of growth-associated protein 43 is not a compelling marker for human nerve regeneration in carpal tunnel syndrome.Applications:Unspecified applicationReactive species:Unspecified reactive speciesLiam Carroll,Oliver Sandy-Hindmarch,Georgios Baskozos,Guan Cheng Zhu,Julia McCarthy,Annina SchmidPubMed 36383568
- iScience 25:1051412022Schwann cells-derived exosomal miR-21 participates in high glucose regulation of neurite outgrowth.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYu-Pu Liu,Ming-Yue Tian,Yi-Duo Yang,Han Li,Tian-Tian Zhao,Jing Zhu,Fang-Fang Mou,Guo-Hong Cui,Hai-Dong Guo,Shui-Jin ShaoPubMed 36204278
- Molecular neurobiology 59:5612-56292022P. edulis Extract Protects Against Amyloid-β Toxicity in Alzheimer's Disease Models Through Maintenance of Mitochondrial Homeostasis via the FOXO3/DAF-16 Pathway.Applications:Unspecified applicationReactive species:Unspecified reactive speciesShu-Qin Cao,Yahyah Aman,Evandro F Fang,Tewin TencomnaoPubMed 35739408
- Frontiers in cellular and infection microbiology 11:6476622021Proteomic Analysis of Rhesus Macaque Brain Explants Treated With Identifies Host GAP-43 as a Potential Factor Associated With Lyme Neuroborreliosis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesLianbao Li,Lisha Luo,Taigui Chen,Wenjing Cao,Xin Xu,Yu Zhang,Peng Yue,Yuxin Fan,Jingjing Chen,Meixiao Liu,Mingbiao Ma,Lvyan Tao,Yun Peng,Yan Dong,Bingxue Li,Suyi Luo,Jing Kong,Guozhong Zhou,Shiyuan Wen,Aihua Liu,Fukai BaoPubMed 34178719
- Molecular therapy. Nucleic acids 21:251-2632020MicroRNA-19a-PTEN Axis Is Involved in the Developmental Decline of Axon Regenerative Capacity in Retinal Ganglion Cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesHeather K Mak et. al.PubMed 32599451
- Theranostics 10:1590-16032020Aligned chitosan nanofiber hydrogel grafted with peptides mimicking bioactive brain-derived neurotrophic factor and vascular endothelial growth factor repair long-distance sciatic nerve defects in rats.Applications:Unspecified applicationReactive species:Unspecified reactive speciesFeng Rao et. al.PubMed 32042324
- Biochemical and biophysical research communication 520:359-3652019Shikonin attenuates sympathetic remodeling in chronic heart failure mice via regulating miR-124.Applications:Unspecified applicationReactive species:Unspecified reactive speciesWen-Lin Liu et. al.PubMed 31604527
- FASEB journal : official publication of the Federa 33:12409-124242019A Schwann cell-enriched circular RNA circ-Ankib1 regulates Schwann cell proliferation following peripheral nerve injury.Applications:Unspecified applicationReactive species:Unspecified reactive speciesSusu Mao et. al.PubMed 31415184
- PloS one 14:e02165272019The evolution and multi-molecular properties of NF1 cutaneous neurofibromas originating from C-fiber sensory endings and terminal Schwann cells at normal sites of sensory terminations in the skin.Applications:Unspecified applicationReactive species:Unspecified reactive speciesFrank L Rice et. al.PubMed 31107888
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
Preservative: 0.01% Sodium azide
- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Native Full Length Protein corresponding to Cat GAP43. Database link Q6S9D9
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Reactivity data
Select an application| IHC-P | |
|---|---|
| Human | Tested |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/2000 | Notes Perform heat-mediated antigen retrieval before commencing with IHC staining protocol. |
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Target data
Function
This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction (By similarity).
Alternative names
Neuromodulin, Axonal membrane protein GAP-43, Growth-associated protein 43, GAP43
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Rabbit Polyclonal GAP43 antibody. Neural Stem Cell marker. Suitable for IHC-P and reacts with Human samples. Cited in 28 publications. Immunogen corresponding to Native Full Length Protein corresponding to Cat GAP43.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
Preservative: 0.01% Sodium azide
- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Native Full Length Protein corresponding to Cat GAP43. Database link Q6S9D9
- Purity
- Whole antiserum
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
GAP43 commonly called Growth Associated Protein 43 or neuronal marker is a protein with a molecular weight of approximately 25-50 kDa. Researchers identify it by various names including GAP-43 GAP43 anticuerpo or GAP43 neuronal marker. This protein exhibits a specific presence in the nervous system especially in axons of neurons. It has significant expression during neural development and regeneration indicating its role in growth and repair.
- Biological function summary
GAP43 plays an important role in neurite outgrowth and synaptic plasticity. It functions as an important mediator of signal transduction in neurons. GAP43 does not act alone but integrates into a network of signaling pathways that guide axonal elongation and branching. It works closely with cytoskeletal elements influencing the structural dynamics needed for effective neuronal response and adaptation.
- Pathways
GAP43 is vital in the regulation of the protein kinase C pathway and the cAMP pathway both essential for neuronal growth and differentiation. It closely interacts with proteins such as calmodulin which binds to GAP43 and impacts its function in those pathways. These interactions highlight its role in the modulation of neuronal growth and synaptic plasticity making it essential for neurons' response to environmental signals.
- Associated diseases and disorders
GAP43 associates with neurodegenerative diseases and cognitive disorders particularly Alzheimer's disease and schizophrenia. Changes in GAP43 expression levels correlate with the severity and progression of these conditions. Additionally GAP43 connects to other proteins implicated in such diseases like tau in Alzheimer's suggesting a multifaceted involvement in disease mechanisms. This makes it a target of interest for therapeutic research as modulating GAP43 activity might alter disease progression.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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1 product image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GAP43 antibody - Neuronal Marker (ab12274)
ab12274 staining human neuropil. Staining is localized to the cytoplasm and membrane.
Left panel: with primary antibody diluted 1:2000. Right panel: isotype control.
Sections were stained using an automated system (Dako PT Link), at room temperature. Sections were rehydrated and antigen retrieved with the Dako 3-in-1 antigen retrieval buffer, citrate pH 6.0. Slides were peroxidase blocked in 3% H2O2 in methanol for 10 minutes. They were then blocked with Dako Protein block for 10 minutes (containing casein 0.25% in PBS) then incubated with primary antibody for 20 minutes and detected with Dako Envision Flex amplification kit for 30 minutes. Colorimetric detection was completed with diaminobenzidine for 5 minutes. Slides were counterstained with Haematoxylin and coverslipped under DePeX. Please note that for manual staining we recommend to optimize the primary antibody concentration and incubation time (overnight incubation), and amplification may be required.
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