AB194929

Anti-GAP43 (phospho S41) antibody

Name: Anti-GAP43 (phospho S41) antibody (ab194929) | Abcam
Brand: Abcam Limited
SKU: AB194929
Rating: 4 (1 reviews)

(1 Review)

(3 Publications)

Rabbit Polyclonal GAP43 phospho S41 antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human GAP43 phospho S41.

View Alternative Names

Neuromodulin, Axonal membrane protein GAP-43, Growth-associated protein 43, Neural phosphoprotein B-50, pp46, GAP43

1 Images

Immunocytochemistry/ Immunofluorescence - Anti-GAP43 (phospho S41) antibody (AB194929)

ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-GAP43 (phospho S41) antibody (AB194929)

Immunofluorescent analysis of methanol fixed Hela cells labeling GAP43 (phospho S41) with ab194929 at 1/100 dilution

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

ICC/IF

applications

Immunogen

Synthetic Peptide within Human GAP43 phospho S41. The exact immunogen used to generate this antibody is proprietary information.

P17677

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/100 - 1/200", "ICCIF-species-notes": "<p></p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.3 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

GAP43 commonly called Growth Associated Protein 43 or neuronal marker is a protein with a molecular weight of approximately 25-50 kDa. Researchers identify it by various names including GAP-43 GAP43 anticuerpo or GAP43 neuronal marker. This protein exhibits a specific presence in the nervous system especially in axons of neurons. It has significant expression during neural development and regeneration indicating its role in growth and repair.

Biological function summary

GAP43 plays an important role in neurite outgrowth and synaptic plasticity. It functions as an important mediator of signal transduction in neurons. GAP43 does not act alone but integrates into a network of signaling pathways that guide axonal elongation and branching. It works closely with cytoskeletal elements influencing the structural dynamics needed for effective neuronal response and adaptation.

Pathways

GAP43 is vital in the regulation of the protein kinase C pathway and the cAMP pathway both essential for neuronal growth and differentiation. It closely interacts with proteins such as calmodulin which binds to GAP43 and impacts its function in those pathways. These interactions highlight its role in the modulation of neuronal growth and synaptic plasticity making it essential for neurons' response to environmental signals.

GAP43 associates with neurodegenerative diseases and cognitive disorders particularly Alzheimer's disease and schizophrenia. Changes in GAP43 expression levels correlate with the severity and progression of these conditions. Additionally GAP43 connects to other proteins implicated in such diseases like tau in Alzheimer's suggesting a multifaceted involvement in disease mechanisms. This makes it a target of interest for therapeutic research as modulating GAP43 activity might alter disease progression.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction.

See full target information GAP43 phospho S41

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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Arteriosclerosis, thrombosis, and vascular biology 44:e117-e130 PubMed38385289

2024

Inhibition of IL-1 Ameliorates Cardiac Dysfunction and Arrhythmias in a Murine Model of Kawasaki Disease.

Applications

Unspecified application

Species

Unspecified reactive species

Thassio Mesquita,Yen-Nien Lin,Shuang Chen,Youngho Lee,Rodrigo Miguel-Dos-Santos,Asli E Atici,Michael C Fishbein,Magali Noval Rivas,Moshe Arditi,Eugenio Cingolani

eNeuro 11: PubMed38262737

2024

Chronic Spinal Cord Injury Regeneration with Combined Therapy Comprising Neural Stem/Progenitor Cell Transplantation, Rehabilitation, and Semaphorin 3A Inhibitor.

Applications

Unspecified application

Species

Unspecified reactive species

Takashi Yoshida,Syoichi Tashiro,Narihito Nagoshi,Munehisa Shinozaki,Takahiro Shibata,Mitsuhiro Inoue,Shoji Ogawa,Shinsuke Shibata,Tetsuya Tsuji,Hideyuki Okano,Masaya Nakamura

Neural regeneration research 18:1961-1967 PubMed36926720

2023

Neuroprotective effects of meloxicam on transient brain ischemia in rats: the two faces of anti-inflammatory treatments.

Applications

Unspecified application

Species

Unspecified reactive species

Irene Fernández Ugidos,Paloma González-Rodríguez,María Santos-Galdiano,Enrique Font-Belmonte,Berta Anuncibay-Soto,Diego Pérez-Rodríguez,José Manuel Gonzalo-Orden,Arsenio Fernández-López

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-GAP43 (phospho S41) antibody

Immunocytochemistry/ Immunofluorescence - Anti-GAP43 (phospho S41) antibody (AB194929)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (3)

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