AB136249

Anti-GAS 6 antibody

Name: Anti-GAS 6 antibody (ab136249) | Abcam
Brand: Abcam Limited
SKU: AB136249
Price: 545 USD
Availability: InStock
Rating: 4 (3 reviews)

(3 Reviews)

(4 Publications)

Rabbit Polyclonal GAS 6 antibody. Suitable for WB and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human GAS6.

View Alternative Names

AXLLG, GAS6, Growth arrest-specific protein 6, GAS-6, AXL receptor tyrosine kinase ligand

1 Images

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Western blot - Anti-GAS 6 antibody (AB136249)

All lanes:

Western blot - Anti-GAS 6 antibody (ab136249) at 1/500 dilution

All lanes:

HT29 cell lysate at 30 µg

Predicted band size: 80 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

applications

Immunogen

Synthetic Peptide within Human GAS6. The exact immunogen used to generate this antibody is proprietary information.

Q14393

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Purification notes

ab136249 was affinity-purified from rabbit antiserum by immunogenic peptide affinity-chromatography.

Storage buffer

pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The protein Gas6 also known as growth arrest-specific 6 weighs approximately 75 kDa and functions mechanically as a ligand for the TAM (Tyro3 Axl and Mer) receptor tyrosine kinases. Gas6 protein facilitates cell signaling by binding especially to AXL receptor initiating various downstream cellular responses. It is widely expressed in different tissues including the nervous system cardiovascular system and kidneys. Additionally its expression increases in response to cellular stress and inflammatory stimuli.

Biological function summary

Gas6 influences several cellular processes such as cell survival proliferation and migration. Gas6 exerts its effects in a complex with AXL receptor which is part of a larger network involving other TAM receptors. By activating AXL Gas6 modulates immune responses inflammation and tissue repair. The protein also plays a significant role in phagocytosis helping remove apoptotic cells thereby maintaining tissue homeostasis.

Pathways

The Gas6 protein is significantly engaged in the PI3K/AKT signaling pathway important for promoting cell survival and inhibiting apoptosis. Additionally Gas6 interacts with the NF-kB pathway which regulates inflammation and immune responses. Both pathways highlight the synergy between Gas6 and AXL emphasizing their contribution to cellular integrity and response to injury.

Gas6's dysregulation associates with cancer and atherosclerosis. In oncogenesis altered Gas6-AXL signaling promotes tumor progression and resistance to therapy implicating it in diverse cancers. Meanwhile in cardiovascular diseases elevated Gas6 levels correlate with atherosclerosis interacting with inflammatory proteins such as interleukins. Understanding Gas6's role in these conditions offers potential for therapeutic targeting and biomarker development.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses.. (Microbial infection) Can bridge virus envelope phosphatidylserine to the TAM receptor tyrosine kinase Axl to mediate viral entry by apoptotic mimicry (PubMed : 21501828). Plays a role in Dengue cell entry by apoptotic mimicry (PubMed : 23084921). Plays a role in Vaccinia virus cell entry by apoptotic mimicry (PubMed : 21501828). Plays a role in ebolavirus and marburgvirus cell entry by apoptotic mimicry (PubMed : 17005688).

See full target information GAS6

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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Cancer cell international 18:4 PubMed29308053

2018

Effect of long non-coding RNA Gas5 on proliferation, migration, invasion and apoptosis of colorectal cancer HT-29 cell line.

Applications

Unspecified application

Species

Unspecified reactive species

Jin Li,Yuan Wang,Cheng-Gong Zhang,Han-Juan Xiao,Hai-Juan Xiao,Jun-Ming Hu,Jun-Ming Hou,Jing-Dong He

Frontiers in immunology 8:1521 PubMed29176978

2017

Requirement of Gamma-Carboxyglutamic Acid Modification and Phosphatidylserine Binding for the Activation of Tyro3, Axl, and Mertk Receptors by Growth Arrest-Specific 6.

Applications

Unspecified application

Species

Unspecified reactive species

Ke Geng,Sushil Kumar,Stanley G Kimani,Vladyslav Kholodovych,Canan Kasikara,Kensaku Mizuno,Oleta Sandiford,Pranela Rameshwar,Sergei V Kotenko,Raymond B Birge

Cancer science 107:882-9 PubMed27145494

2016

A prognostic risk model for patients with triple negative breast cancer based on stromal natural killer cells, tumor-associated macrophages and growth-arrest specific protein 6.

Applications

IHC-P

Species

Human

Wenjing Tian,Le Wang,Lili Yuan,Wenming Duan,Wenhui Zhao,Shuhuai Wang,Qingyuan Zhang

Cell systems 1:25-36 PubMed26236777

2015

The AXL Receptor is a Sensor of Ligand Spatial Heterogeneity.

Applications

Species

Unspecified reactive species

Aaron S Meyer,Annelien J M Zweemer,Douglas A Lauffenburger

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-GAS 6 antibody

Western blot - Anti-GAS 6 antibody (AB136249)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Purification notes

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (4)

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