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AB241364

Anti-GAS2L3 antibody

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(1 Publication)

Rabbit Polyclonal GAS2L3 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human GAS2L3 aa 1-50.

View Alternative Names

GAS2-like protein 3, Growth arrest-specific protein 2-like 3, GAS2L3

1 Images
Western blot - Anti-GAS2L3 antibody (AB241364)
  • WB

Supplier Data

Western blot - Anti-GAS2L3 antibody (AB241364)

All lanes:

Western blot - Anti-GAS2L3 antibody (ab241364) at 0.1 µg/mL

Lane 1:

HeLa (human epithelial cell line from cervix adenocarcinoma) whole cell lysate at 50 µg

Lane 2:

HEK-293T (human epithelial cell line from embryonic kidney transformed with large T antigen) whole cell lysate at 50 µg

Lane 3:

Jurkat (human T cell leukemia cell line from peripheral blood) whole cell lysate at 50 µg

Lane 4:

K562 (human chronic myelogenous leukemia cell line from bone marrow) whole cell lysate at 50 µg

Lane 5:

MCF7 (human breast adenocarcinoma cell line) whole cell lysate at 50 µg

Lane 6:

HepG2 (human liver hepatocellular carcinoma cell line) whole cell lysate at 50 µg

Predicted band size: 75 kDa

true

Exposure time: 3min

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human GAS2L3 aa 1-50. The exact immunogen used to generate this antibody is proprietary information.

Q86XJ1

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/2000 - 1/10000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
ab241364 was affinity purified using an epitope specific to GAS2L3 immobilized on solid support.
Storage buffer
pH: 7 - 8 Preservative: 0.09% Sodium azide Constituents: Tris citrate/phosphate
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

GAS2L3 also known as GAS2-like protein 3 is a cytoskeletal-associated protein with a molecular mass of approximately 71 kDa. It often cooperates with actin and microtubules to stabilize the cell structure. Expression of GAS2L3 occurs in many tissues but it finds higher levels in proliferative cells particularly during mitosis. It carries unique domains that allow connections between the cytoskeleton components influencing cell shape and dynamics.
Biological function summary

GAS2L3 influences cell cycle progression and mitotic spindle organization acting as a part of the cell division machinery. This protein interacts with other cell division cycle proteins that ensure accurate chromosome segregation. Its association with the Ndc80 complex assists in the proper attachment of chromosomes to spindle microtubules. Failures in its function could affect spindle integrity which may lead to errors in cell division.

Pathways

GAS2L3 is significant in the regulation of the cell cycle and the actin cytoskeleton pathway. It connects with regulatory proteins such as Cyclin-dependent kinases which are key players in cell cycle advancement. GAS2L3's interaction with actin-binding proteins like cortactin shows its involvement in actin remodeling processes. These pathways highlight the complex network controlled by GAS2L3 to maintain orderly cell division and stability.

GAS2L3 dysfunction associates with cancerous pathologies and cell proliferation-related disorders. Changes in its normal activity can contribute to malignancies due to erroneous mitotic segregation and genome instability. GAS2L3 interacts with proteins such as p53 a well-known tumor suppressor indicating its potential role in tumorigenic processes when aberrations occur. Understanding GAS2L3’s contributions to these conditions reveals potential therapeutic targets for maintaining genomic fidelity.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Cytoskeletal linker protein. May promote and stabilize the formation of the actin and microtubule network.
See full target information GAS2L3
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cell death discovery 7:392 PubMed34907164

2021

CRISPR/Cas9 genome-wide screening identifies LUC7L2 that promotes radioresistance via autophagy in nasopharyngeal carcinoma cells.

Applications

Unspecified application

Species

Unspecified reactive species

Lin Shen,Chao Li,Fang Chen,Liangfang Shen,Zhanzhan Li,Na Li
View all publications
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Product promise

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