JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB127198

Anti-GAS41 antibody

Be the first to review this product! Submit a review

|

(1 Publication)

Rabbit Polyclonal GAS41 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human YEATS4 aa 1-200.

View Alternative Names

GAS41, YEATS4, YEATS domain-containing protein 4, Glioma-amplified sequence 41, NuMA-binding protein 1, Gas41, NuBI-1, NuBI1

1 Images
Western blot - Anti-GAS41 antibody (AB127198)
  • WB

Unknown

Western blot - Anti-GAS41 antibody (AB127198)

12% SDS-PAGE

All lanes:

Western blot - Anti-GAS41 antibody (ab127198) at 1/1000 dilution

All lanes:

A549 whole cell lysate at 30 µg

Predicted band size: 26 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human YEATS4 aa 1-200. The exact immunogen used to generate this antibody is proprietary information.

O95619

style
left-column

Alternative Products

Primary Antibodies

AB205018

Anti-GAS41 antibody

Immunoprecipitation - Anti-GAS41 antibody (AB205018)

  • 5
  • 1

Complementary Products

Primary Antibodies

AB1791

Anti-Histone H3 antibody - Nuclear Marker and ChIP Grade

Lab Essentials

ChIP - Anti-Histone H3 antibody - Nuclear Marker and ChIP Grade (AB1791)

  • 5
  • 233
Primary Antibodies

AB177790

Anti-Histone H4 (acetyl K5 + K8 + K12 + K16) antibody [EPR16606]

RabMAb|Advanced Validation|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-Histone H4 (acetyl K5 + K8 + K12 + K16) antibody [EPR16606] (AB177790)

  • 5
  • 2
Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Primary Antibodies

AB4174

Anti-Histone H2A.Z antibody - ChIP Grade

Western blot - Anti-Histone H2A.Z antibody - ChIP Grade (AB4174)

  • 4
  • 31
style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Chicken": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Sheep": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Xenopus laevis": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Zebrafish": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The protein GAS41 also known as Glioma-Amplified Sequence 41 weighs approximately 26 kDa. It is ubiquitously expressed in various cell types including brain and neuronal tissues. GAS41 performs as a component of the chromatin remodeling complex. This protein participates in DNA binding and potentially regulates transcription processes influencing gene expression patterns.
Biological function summary

GAS41 impacts cellular proliferation and organization. It is often part of the Tip60/NuA4 histone acetyltransferase complex which is involved in chromatin modification. Through its role in this complex GAS41 influences transcriptional regulation by modifying chromatin architecture. This process ultimately affects how genes are turned on or off in cells which is key for maintaining cellular function and identity.

Pathways

GAS41 plays a significant role in the regulation of gene expression pathways and cell cycle control. It interacts with proteins in the SWI/SNF-related chromatin remodeler pathways and modulates how genes involved in cell cycle progression are expressed. GAS41 shows interaction with proteins like p400 which also contributes to these pathways indicating its importance in cellular growth and division.

GAS41 is linked to glioma progression and certain neurodegenerative disorders. Changes in the expression of GAS41 have been observed in gliomas connecting it with the uncontrolled cell growth characteristic of these tumors. Through its association with other proteins like ATRX GAS41 is implicated in chromatin remodeling disturbances seen in neurodegenerative diseases influencing gene expression patterns and contributing to disease pathogenesis.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

Chromatin reader component of the NuA4 histone acetyltransferase (HAT) complex, a complex involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A (PubMed : 12963728, PubMed : 14966270). Specifically recognizes and binds acylated histone H3, with a preference for histone H3 diacetylated at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac) or histone H3 diacetylated at 'Lys-14' and 'Lys-27' (H3K14ac and H3K27ac) (PubMed : 29437725, PubMed : 29900004, PubMed : 30071723). Also able to recognize and bind crotonylated histone H3 (PubMed : 30071723). May also recognize and bind histone H3 succinylated at 'Lys-122' (H3K122succ); additional evidences are however required to confirm this result in vivo (PubMed : 29463709). Plays a key role in histone variant H2AZ1/H2A.Z deposition into specific chromatin regions : recognizes and binds H3K14ac and H3K27ac on the promoters of actively transcribed genes and recruits NuA4-related complex to deposit H2AZ1/H2A.Z (PubMed : 29437725). H2AZ1/H2A.Z deposition is required for maintenance of embryonic stem cell (By similarity).
See full target information YEATS4
style
left-column

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Molecular medicine reports 32: PubMed40709397

2025

Pan‑cancer analysis of the carcinogenic role of WSB2 in human tumors.

Applications

Unspecified application

Species

Unspecified reactive species

Yingzi Deng,Yifei Li,Ruobing Li,Xiaohui Guo,Yan Liu,Shuqing Wang,Juan Zhang,Mi Li,Lina Zhao,Haifeng Cai,Yunfeng Zhang,Fen Hu
View all publications
style
left-column
style
left-column
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com