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AB216017

Anti-Gastric Mucin/MUC-6 antibody [MUC6/916]

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(7 Publications)

Mouse Monoclonal Gastric Mucin/MUC-6 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 7 publications. Immunogen corresponding to Recombinant Fragment Protein within Human MUC6.

View Alternative Names

Mucin-6, MUC-6, Gastric mucin-6, MUC6

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Gastric Mucin/MUC-6 antibody [MUC6/916] (AB216017)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Gastric Mucin/MUC-6 antibody [MUC6/916] (AB216017)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded human gastric carcinoma tissue labeling Gastric Mucin/MUC-6 with ab216017 at 4 μg/ml.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Gastric Mucin/MUC-6 antibody [MUC6/916] (AB216017)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Gastric Mucin/MUC-6 antibody [MUC6/916] (AB216017)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded human gastric carcinoma tissue labeling Gastric Mucin/MUC-6 with ab216017 at 4 μg/ml.

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

MUC6/916

Isotype

IgG1

Light chain type

kappa

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human MUC6.

Q6W4X9

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "2-4 µg/mL", "IHCP-species-notes": "<p>(Primary incubation for 30 minutes at RT).</p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." }, "Rat": { "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "2-4 µg/mL", "IHCP-species-notes": "<p>(Primary incubation for 30 minutes at RT).</p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A/G
Purification notes
ab216017 was purified from Bioreactor Concentrate by Protein A/G.
Storage buffer
pH: 7.2 - 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 0.05% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

MUC-6 also called gastric mucin is a large glycoprotein with a molecular mass around 500-1000 kDa. Cells in the stomach express MUC-6 where it plays a critical mechanical role in forming protective mucous barriers against harsh gastric environments. The glycoprotein forms viscous gels that coat the gastric mucosa creating a protective layer. These layers prevent autodigestion by gastric acid and pepsin safeguarding the underlying epithelium from damage.
Biological function summary

MUC-6 contributes to the defense of gastric tissues through its complex structure. The protein belongs to the mucin family characterized by their high carbohydrate content. MUC-6 interacts with other secreted mucins like MUC-5AC to form a protective gel. It acts as an important component in the maintenance of the gastric mucosal barrier ensuring the separation of stomach contents and epithelial surface. This gel traps pathogens and particles reducing their ability to cause infection or irritation.

Pathways

MUC-6 plays a role in mucosal immunity and epithelial signaling pathways. In the gastric mucosa pathway it links with proteins such as CLCA1 which influences mucin secretion and function. Another linked pathway is the oxidative stress pathway where MUC-6 partners with antioxidant enzymes to shield the stomach lining from oxidative damage. These pathways showcase how MUC-6 integrates a mechanical and biological defense system within the digestive tract.

Alterations in MUC-6 expression levels can influence conditions like gastric cancer and peptic ulcer disease. In gastric cancer abnormal methylation of the MUC-6 gene can contribute to tumorigenesis and tumor progression. In peptic ulcer disease deficient mucin levels particularly MUC-6 compromise the mucosal barrier function. Connections also exist with proteins like gastrin which elevate acid production and burden the mucosal defense emphasizing the relevance of MUC-6 in these gastric conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

May provide a mechanism for modulation of the composition of the protective mucus layer related to acid secretion or the presence of bacteria and noxious agents in the lumen. Plays an important role in the cytoprotection of epithelial surfaces and are used as tumor markers in a variety of cancers. May play a role in epithelial organogenesis.
See full target information MUC6
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Publications (7)

Recent publications for all applications. Explore the full list and refine your search

Cellular and molecular gastroenterology and hepatology 18:101366 PubMed38815928

2024

Interleukin 13 Promotes Maturation and Proliferation in Metaplastic Gastroids.

Applications

Unspecified application

Species

Unspecified reactive species

Ela W Contreras-Panta,Su-Hyung Lee,Yoonkyung Won,Allison E Norlander,Alan J Simmons,R Stokes Peebles,Ken S Lau,Eunyoung Choi,James R Goldenring

Pediatric surgery international 40:6 PubMed37999863

2023

Generation of human gastric assembloids from primary fetal organoids.

Applications

Unspecified application

Species

Unspecified reactive species

Giada Benedetti,Brendan C Jones,Francesca Sgualdino,Paolo De Coppi,Giovanni Giuseppe Giobbe

Microbiome 11:86 PubMed37085819

2023

Mucin-microbiome signatures shape the tumor microenvironment in gastric cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Baptiste Oosterlinck,Hannah Ceuleers,Wout Arras,Joris G De Man,Karen Geboes,Heiko De Schepper,Marc Peeters,Sarah Lebeer,Jurgita Skieceviciene,Georgina L Hold,Juozas Kupcinskas,Alexander Link,Benedicte Y De Winter,Annemieke Smet

Frontiers in cell and developmental biology 11:1151790 PubMed36994101

2023

Shared features of metaplasia and the development of adenocarcinoma in the stomach and esophagus.

Applications

Unspecified application

Species

Unspecified reactive species

Yongji Zeng,Qing K Li,Sujayita Roy,Jason C Mills,Ramon U Jin

Translational cancer research 10:3053-3058 PubMed35116613

2022

A case report of endoscopic submucosal dissection for a new subtype of gastric adenoma: mixed fundic and pyloric mucosa type.

Applications

Unspecified application

Species

Unspecified reactive species

Liu Han,Yuyong Tan,Deliang Liu,Songqing Fan,Lei Shi,Chengbai Liang

Pediatric surgery international : PubMed33495862

2021

Paediatric gastric organoids as a tool for disease modelling and clinical translation.

Applications

Unspecified application

Species

Unspecified reactive species

Brendan C Jones,Giuseppe Calà,Paolo De Coppi,Giovanni Giuseppe Giobbe

Histochemistry and cell biology 151:21-28 PubMed30159783

2018

Expression and localization of aromatase in human gastric mucosa : Immunohistochemical study using biopsy materials.

Applications

Unspecified application

Species

Unspecified reactive species

Hiroto Kobayashi,Saori Yoshida,Nobuyuki Shirasawa,Kunihiko Maeda,Akira Naito
View all publications
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Product promise

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