Anti-Gastrokine 1 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

Gastrokine 1 also known as GKN1 is a protein with a molecular weight of approximately 18 kDa. It is expressed mainly in the gastric epithelium. This protein plays a mechanical role in maintaining gastric mucosal integrity. It has been associated with epithelial cell differentiation and proliferation a process important for stomach lining health. Gastrokine 1 interacts with other cellular components to stabilize and repair the gastric mucosa following injury or stress.

Biological function summary

This protein supports gastric mucosal defense mechanisms. It participates in maintaining the epithelial barrier against harmful digestive enzymes and pathogens. Gastrokine 1 is not part of a larger protein complex but operates independently to influence mucosal protection. Its ability to modulate cell turnover and repair processes highlights its importance in sustaining gastric homeostasis.

Pathways

Gastrokine 1 functions within the gastric mucosal protective pathway. It often relates to the signaling pathways involving epidermal growth factor receptor (EGFR) and inflammation mediation. The absence or reduction of GKN1 can disrupt these pathways impacting other proteins such as MUC5AC which also contribute to the protective mucosal barrier. The interaction between these proteins ensures a coordinated response in maintaining the stomach lining integrity.

Associated diseases and disorders

Alterations in Gastrokine 1 expression have associations with gastric cancer and gastritis. Reduced levels of this protein often correspond with increased gastric epithelial damage and carcinogenesis risks. GKN1's association with diseases like gastric cancer makes it a potential biomarker. Additionally its interaction with Helicobacter pylori a bacterium linked to chronic gastritis and cancer demonstrates the protein's critical role in disease prevention.