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AB110093

Anti-GATA3 antibody [KT77]

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(4 Publications)

Rat Monoclonal GATA3 phospho S308 antibody. Suitable for WB, ICC/IF and reacts with Mouse samples. Cited in 4 publications. Immunogen corresponding to Full Length Protein corresponding to Mouse Gata3 phospho S308.

View Alternative Names

Gata-3, Gata3, Trans-acting T-cell-specific transcription factor GATA-3, GATA-binding factor 3

Key facts

Host species

Rat

Clonality

Monoclonal

Clone number

KT77

Isotype

IgG2a

Carrier free

No

Reacts with

Mouse

Applications

WB, ICC/IF

applications

Immunogen

Full Length Protein corresponding to Mouse Gata3 phospho S308. The exact immunogen used to generate this antibody is proprietary information.

P23772

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "1/500 - 1/10000", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "1/100 - 1/1000", "ICCIF-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Storage buffer
Preservative: 0.1% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

GATA3 also known as GATA-binding factor 3 is a transcription factor with a molecular mass of about 50 kDa. It belongs to the GATA family of zinc finger transcription factors. GATA3 is mainly expressed in the immune system especially in T-cells as well as in the nervous system and mammary glands. It plays a role in the regulation of critical developmental processes and cell lineage commitment through its binding to the 'GATA' motif in the promoter regions of target genes.
Biological function summary

GATA3 functions as a regulator of gene expression involved in various differentiation processes. It is not a solitary molecule; it interacts with other proteins to form transcriptional complexes. In T-helper type 2 (Th2) cells GATA3 is necessary for Th2 cell differentiation and cytokine production. Its expression is vital for the development of the nervous system and mammary gland morphogenesis highlighting its role in diverse biological contexts.

Pathways

GATA3 plays a significant role in the Th2 differentiation pathway and is linked to the immune response. It acts in association with other transcription factors like STAT6 and T-bet. GATA3 promotes the transcription of Th2 cytokines such as IL-4 IL-5 and IL-13 while suppressing Th1 responses. This balance orchestrated by GATA3 is important for immune homeostasis and the body's ability to respond to infections and allergens.

The dysregulation of GATA3 is associated with atopic diseases and breast cancer. Aberrant expression of GATA3 is often observed in allergic conditions due to its role in Th2 cell differentiation and cytokine expression. In the context of breast cancer GATA3 levels can impact tumor progression and are correlated with estrogen receptor status. Additionally its relation with other breast cancer-related proteins like L50 underlines its importance in cancer biology and potential as a therapeutic target.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'. Required for the T-helper 2 (Th2) differentiation process following immune and inflammatory responses. Positively regulates ASB2 expression (PubMed : 31175139). Coordinates macrophage transcriptional activation and UCP2-dependent metabolic reprogramming in response to IL33. Upon tissue injury, acts downstream of IL33 signaling to drive differentiation of inflammation-resolving alternatively activated macrophages.
See full target information Gata3 phospho S308
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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Science advances 11:eadx4511 PubMed40938992

2025

The citrullinating enzyme PADI4 governs progenitor cell proliferation and translation in developing hair follicles.

Applications

Unspecified application

Species

Unspecified reactive species

Kim Vikhe Patil,Nil Campamà Sanz,Kylie Hin-Man Mak,Wei Yang,Karl Annusver,Jasson Makkar,David Grommisch,Li Lei,Priyanka Sharma,Ryan R Driskell,Maria Kasper,Maria Genander

Clinical and translational allergy 13:e12265 PubMed37357549

2023

Interleukin-33 increases type 2 innate lymphoid cell count and their activation in eosinophilic asthma.

Applications

Unspecified application

Species

Unspecified reactive species

Fengfei Sun,Wei Zou,Honglei Shi,Zehu Chen,Donghai Ma,Minmin Lin,Kongqiu Wang,Yiying Huang,Xiaobin Zheng,Cuiyan Tan,Meizhu Chen,Changli Tu,Zhenguo Wang,Jian Wu,Weiming Wu,Jing Liu

Cell proliferation 53:e12827 PubMed32406154

2020

Calcitriol inhibits osteoclastogenesis in an inflammatory environment by changing the proportion and function of T helper cell subsets (Th2/Th17).

Applications

Unspecified application

Species

Unspecified reactive species

Chun-Sheng Bi,Xuan Li,Hong-Lei Qu,Li-Juan Sun,Ying An,Yong-Long Hong,Bei-Min Tian,Fa-Ming Chen

Nature communications 8:15781 PubMed28589929

2017

Type-2 innate lymphoid cells control the development of atherosclerosis in mice.

Applications

IHC-Fr

Species

Mouse

Stephen A Newland,Sarajo Mohanta,Marc Clément,Soraya Taleb,Jennifer A Walker,Meritxell Nus,Andrew P Sage,Changjun Yin,Desheng Hu,Lauren L Kitt,Alison J Finigan,Hans-Reimer Rodewald,Christoph J Binder,Andrew N J McKenzie,Andreas J Habenicht,Ziad Mallat
View all publications
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