Rabbit Polyclonal GDF 5 antibody. Suitable for WB and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human Growth/differentiation factor 5 aa 400 to C-terminus.
IgG
Rabbit
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Liquid
Polyclonal
WB | |
---|---|
Human | Tested |
Mouse | Tested |
Chicken | Predicted |
Cow | Predicted |
Rabbit | Predicted |
Xenopus laevis | Predicted |
Xenopus tropicalis | Predicted |
Species | Dilution info | Notes |
---|---|---|
Species Mouse | Dilution info 1/500.00000 - 1/3000.00000 | Notes - |
Species Human | Dilution info 1/500.00000 - 1/3000.00000 | Notes - |
Species | Dilution info | Notes |
---|---|---|
Species Rabbit, Chicken, Cow, Xenopus laevis, Xenopus tropicalis | Dilution info - | Notes - |
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Growth factor involved in bone and cartilage formation. During cartilage development regulates differentiation of chondrogenic tissue through two pathways. Firstly, positively regulates differentiation of chondrogenic tissue through its binding of high affinity with BMPR1B and of less affinity with BMPR1A, leading to induction of SMAD1-SMAD5-SMAD8 complex phosphorylation and then SMAD protein signaling transduction (PubMed:15530414, PubMed:21976273, PubMed:24098149, PubMed:25092592). Secondly, negatively regulates chondrogenic differentiation through its interaction with NOG (PubMed:21976273). Required to prevent excessive muscle loss upon denervation. This function requires SMAD4 and is mediated by phosphorylated SMAD1/5/8 (By similarity). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205).
BMP14, CDMP1, BMP14, CDMP1, GDF5, Growth/differentiation factor 5, GDF-5, Bone morphogenetic protein 14, Cartilage-derived morphogenetic protein 1, Lipopolysaccharide-associated protein 4, Radotermin, BMP-14, CDMP-1, LAP-4, LPS-associated protein 4
Rabbit Polyclonal GDF 5 antibody. Suitable for WB and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human Growth/differentiation factor 5 aa 400 to C-terminus.
IgG
Rabbit
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Liquid
Polyclonal
Affinity purification Immunogen
Blue Ice
+4°C
-20°C
Upon delivery aliquot
Avoid freeze / thaw cycle
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7.5% SDS PAGE
All lanes: Western blot - Anti-GDF 5 antibody - C-terminal (ab137698) at 1/500 dilution
Lane 1: Whole cell lysate prepared from 293T cells at 30 µg
Lane 2: Whole cell lysate prepared from A431 cells at 30 µg
Lane 3: Whole cell lysate prepared from H1299 cells at 30 µg
Predicted band size: 55 kDa
7.5% SDS PAGE
All lanes: Western blot - Anti-GDF 5 antibody - C-terminal (ab137698) at 1/1000 dilution
Lane 1: Whole cell lysate prepared from NIH-3T3 cells at 30 µg
Lane 2: Whole cell lysate prepared from JC cells at 30 µg
Predicted band size: 55 kDa
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