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AB137698

Anti-GDF 5 antibody - C-terminal

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(2 Publications)

Rabbit Polyclonal GDF 5 antibody. Suitable for WB and reacts with Mouse, Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human GDF5 aa 400 to C-terminus.

View Alternative Names

BMP14, CDMP1, GDF5, Growth/differentiation factor 5, GDF-5, Bone morphogenetic protein 14, Cartilage-derived morphogenetic protein 1, Lipopolysaccharide-associated protein 4, Radotermin, BMP-14, CDMP-1, LAP-4, LPS-associated protein 4

2 Images
Western blot - Anti-GDF 5 antibody - C-terminal (AB137698)
  • WB

Unknown

Western blot - Anti-GDF 5 antibody - C-terminal (AB137698)

7.5% SDS PAGE

All lanes:

Western blot - Anti-GDF 5 antibody - C-terminal (ab137698) at 1/500 dilution

Lane 1:

Whole cell lysate prepared from 293T cells at 30 µg

Lane 2:

Whole cell lysate prepared from A431 cells at 30 µg

Lane 3:

Whole cell lysate prepared from H1299 cells at 30 µg

Predicted band size: 55 kDa

false

Western blot - Anti-GDF 5 antibody - C-terminal (AB137698)
  • WB

Unknown

Western blot - Anti-GDF 5 antibody - C-terminal (AB137698)

7.5% SDS PAGE

All lanes:

Western blot - Anti-GDF 5 antibody - C-terminal (ab137698) at 1/1000 dilution

Lane 1:

Whole cell lysate prepared from NIH-3T3 cells at 30 µg

Lane 2:

Whole cell lysate prepared from JC cells at 30 µg

Predicted band size: 55 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human GDF5 aa 400 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

P43026

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>" }, "Chicken": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rabbit": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Xenopus laevis": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Xenopus tropicalis": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Growth factor involved in bone and cartilage formation. During cartilage development regulates differentiation of chondrogenic tissue through two pathways. Firstly, positively regulates differentiation of chondrogenic tissue through its binding of high affinity with BMPR1B and of less affinity with BMPR1A, leading to induction of SMAD1-SMAD5-SMAD8 complex phosphorylation and then SMAD protein signaling transduction (PubMed : 15530414, PubMed : 21976273, PubMed : 24098149, PubMed : 25092592). Secondly, negatively regulates chondrogenic differentiation through its interaction with NOG (PubMed : 21976273). Required to prevent excessive muscle loss upon denervation. This function requires SMAD4 and is mediated by phosphorylated SMAD1/5/8 (By similarity). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed : 11276205).
See full target information GDF5
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Cells 10: PubMed34440643

2021

Concurrent BMP Signaling Maintenance and TGF-β Signaling Inhibition Is a Hallmark of Natural Resistance to Muscle Atrophy in the Hibernating Bear.

Applications

Unspecified application

Species

Unspecified reactive species

Laura Cussonneau,Christian Boyer,Charlotte Brun,Christiane Deval,Emmanuelle Loizon,Emmanuelle Meugnier,Elise Gueret,Emeric Dubois,Daniel Taillandier,Cécile Polge,Daniel Béchet,Guillemette Gauquelin-Koch,Alina L Evans,Jon M Arnemo,Jon E Swenson,Stéphane Blanc,Chantal Simon,Etienne Lefai,Fabrice Bertile,Lydie Combaret

Placenta 50:44-52 PubMed28161061

2017

Protective proteins and telomere length in placentas from patients with pre-eclampsia in the last trimester of gestation.

Applications

Unspecified application

Species

Unspecified reactive species

Autumn J Broady,Matthew H Loichinger,Hyeong Jun Ahn,Philip M C Davy,Richard C Allsopp,Gillian D Bryant-Greenwood
View all publications
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