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AB73288

Anti-GDF6 antibody

5

(4 Reviews)

|

(3 Publications)

Rabbit Polyclonal GDF6 antibody. Suitable for WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human GDF6.

View Alternative Names

BMP13, GDF16, GDF6, Growth/differentiation factor 6, GDF-6, Bone morphogenetic protein 13, Growth/differentiation factor 16, BMP-13

2 Images
Western blot - Anti-GDF6 antibody (AB73288)
  • WB

Unknown

Western blot - Anti-GDF6 antibody (AB73288)

Lane 1:

Western blot - Anti-GDF6 antibody (ab73288) at 0.5 µg/mL

Lane 2:

Western blot - Anti-GDF6 antibody (ab73288) at 1 µg/mL

All lanes:

SK-N-SH lysate at 15 µg

Predicted band size: 51 kDa

Observed band size: 55 kDa

false

Western blot - Anti-GDF6 antibody (AB73288)
  • WB

Unknown

Western blot - Anti-GDF6 antibody (AB73288)

ab50230 is a homodimer consisting of two 120aa monomers. The homodimer format is expected to run at 27kDa, so the observed band is thought to be the monomer form.

All lanes:

Western blot - Anti-GDF6 antibody (ab73288) at 1 µg/mL

Lane 1:

Western blot - Recombinant Human GDF6 protein (<a href='/en-us/products/proteins-peptides/recombinant-human-gdf6-protein-ab50230'>ab50230</a>) at 0.1 µg

Lane 2:

Western blot - Recombinant Human GDF6 protein (<a href='/en-us/products/proteins-peptides/recombinant-human-gdf6-protein-ab50230'>ab50230</a>) at 0.01 µg

Secondary

All lanes:

Western blot - Goat Anti-Rabbit IgG H&L (HRP) preadsorbed (<a href='/en-us/products/secondary-antibodies/goat-rabbit-igg-h-l-hrp-preadsorbed-ab97080'>ab97080</a>) at 1/5000 dilution

Predicted band size: 51 kDa

true

Exposure time: 30s

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human GDF6. The exact immunogen used to generate this antibody is proprietary information.

Q6KF10

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-1 µg/mL", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Growth factor that controls proliferation and cellular differentiation in the retina and bone formation. Plays a key role in regulating apoptosis during retinal development. Establishes dorsal-ventral positional information in the retina and controls the formation of the retinotectal map (PubMed : 23307924). Required for normal formation of bones and joints in the limbs, skull, digits and axial skeleton. Plays a key role in establishing boundaries between skeletal elements during development. Regulation of GDF6 expression seems to be a mechanism for evolving species-specific changes in skeletal structures. Seems to positively regulate differentiation of chondrogenic tissue through the growth factor receptors subunits BMPR1A, BMPR1B, BMPR2 and ACVR2A, leading to the activation of SMAD1-SMAD5-SMAD8 complex. The regulation of chondrogenic differentiation is inhibited by NOG (PubMed : 26643732). Also involved in the induction of adipogenesis from mesenchymal stem cells. This mechanism acts through the growth factor receptors subunits BMPR1A, BMPR2 and ACVR2A and the activation of SMAD1-SMAD5-SMAD8 complex and MAPK14/p38 (By similarity).
See full target information GDF6
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Development (Cambridge, England) 151: PubMed38785133

2024

Multiple intersecting pathways are involved in CPEB1 phosphorylation and regulation of translation during mouse oocyte meiosis.

Applications

Unspecified application

Species

Unspecified reactive species

Chisato Kunitomi,Mayra Romero,Enrico Maria Daldello,Karen Schindler,Marco Conti

European journal of medical research 27:205 PubMed36253873

2022

Construction of mRNA prognosis signature associated with differentially expressed genes in early stage of stomach adenocarcinomas based on TCGA and GEO datasets.

Applications

Unspecified application

Species

Unspecified reactive species

Fuquan Jiang,Haiguan Lin,Hongfeng Yan,Xiaomin Sun,Jianwu Yang,Manku Dong

Arteriosclerosis, thrombosis, and vascular biology 41:698-710 PubMed33054395

2020

Fibroblast Nox2 (NADPH Oxidase-2) Regulates ANG II (Angiotensin II)-Induced Vascular Remodeling and Hypertension via Paracrine Signaling to Vascular Smooth Muscle Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Craig B Harrison,Silvia Cellone Trevelin,Daniel A Richards,Celio X C Santos,Greta Sawyer,Andrea Markovinovic,Xiaohong Zhang,Min Zhang,Alison C Brewer,Xiaoke Yin,Manuel Mayr,Ajay M Shah
View all publications
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