AB186855

Anti-GDNF Receptor alpha 1/GFRA1 antibody

Name: Anti-GDNF Receptor alpha 1/GFRA1 antibody (ab186855) | Abcam
Brand: Abcam Limited
SKU: AB186855
Price: 525 USD
Availability: InStock
Rating: 3 (1 reviews)

(1 Review)

(7 Publications)

Rabbit Polyclonal GDNF Receptor alpha 1/GFRA1 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 7 publications. Immunogen corresponding to Recombinant Fragment Protein within Human GFRA1 aa 1-300.

View Alternative Names

GDNFRA, RETL1, TRNR1, GFRA1, GDNF family receptor alpha-1, GDNF receptor alpha-1, GDNFR-alpha-1, GFR-alpha-1, RET ligand 1, TGF-beta-related neurotrophic factor receptor 1

2 Images

Immunocytochemistry/ Immunofluorescence - Anti-GDNF Receptor alpha 1/GFRA1 antibody (AB186855)

ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-GDNF Receptor alpha 1/GFRA1 antibody (AB186855)

Immunocytochemistry/Immunofluorescence analysis of U2OS cells using ab186855. Blue DAPI for nuclear staining.

Supplier Data

Western blot - Anti-GDNF Receptor alpha 1/GFRA1 antibody (AB186855)

All lanes:

Western blot - Anti-GDNF Receptor alpha 1/GFRA1 antibody (ab186855) at 1/500 dilution

Lane 1:

MCF7 cell extract

Lane 2:

A549 cell extract

Lane 3:

SW480 cell extract

Predicted band size: 51 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

WB, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human GFRA1 aa 1-300. The exact immunogen used to generate this antibody is proprietary information.

P56159

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "<p></p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.3 Preservative: 0.02% Sodium azide Constituents: 50% Glycerol (glycerin, glycerine), 49% PBS

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Coreceptor for GDNF, a neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake (PubMed : 10829012, PubMed : 31535977). GDNF-binding leads to autophosphorylation and activation of the RET receptor (PubMed : 31535977).

See full target information GFRA1

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Publications (7)

Recent publications for all applications. Explore the full list and refine your search

International journal of stem cells 17:298-308 PubMed38225887

2024

Cytoplasmatic Localization of Six1 in Male Testis and Spermatogonial Stem Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Mingming Qin,Linzi Ma,Wenjing Du,Dingyao Chen,Guoqun Luo,Zhaoting Liu

Molecular reproduction and development 89:632-645 PubMed36409004

2022

Dysregulated genes in undifferentiated spermatogonia and Sertoli cells are associated with the spermatogenic arrest in cattleyak.

Applications

Unspecified application

Species

Unspecified reactive species

Peng Zhang,Mingxiu Wang,Xuemei Chen,Kemin Jing,Yuqian Li,Xinrui Liu,Hongbiao Ran,Jie Qin,Jincheng Zhong,Xin Cai

Endocrinology 162: PubMed33713403

2021

Thy1-Positive Spermatogonia Suppress the Proliferation of Spermatogonial Stem Cells by Extracellular Vesicles In Vitro.

Applications

Unspecified application

Species

Unspecified reactive species

Yu Lin,Qian Fang,Yue He,Xiaowen Gong,Yinjuan Wang,Ajuan Liang,Guishuan Wang,Shengnan Gong,Ji Wu,Fei Sun

World journal of stem cells 12:500-513 PubMed32742567

2020

Cytotoxicity of nonylphenol on spermatogonial stem cells phosphatidylinositol-3-kinase/protein kinase B/mammalian target of rapamycin pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Jun-Hao Lei,Wen Yan,Chun-Hua Luo,Yu-Ming Guo,Yang-Yang Zhang,Xing-Huan Wang,Xin-Jun Su

Frontiers in cellular neuroscience 13:351 PubMed31456664

2019

Dl-3-n-Butylphthalide Reduces Cognitive Impairment Induced by Chronic Cerebral Hypoperfusion Through GDNF/GFRα1/Ret Signaling Preventing Hippocampal Neuron Apoptosis.

Applications

Unspecified application

Species

Unspecified reactive species

Wenxian Li,Di Wei,Jiaxing Lin,Jianye Liang,Xiaomei Xie,Kangping Song,Li'an Huang

Behavioural brain research 347:436-445 PubMed29580890

2018

Mifepristone attenuates depression-like changes induced by chronic central administration of interleukin-1β in rats.

Applications

Unspecified application

Species

Unspecified reactive species

Yong-Ping Zhang,Hao-Yin Wang,Cai Zhang,Bai-Ping Liu,Zhi-Lan Peng,Yu-Yu Li,Feng-Ming Liu,Cai Song

Investigative ophthalmology & visual science 58:4695-4702 PubMed28910445

2017

Corneal Epithelium-Derived Neurotrophic Factors Promote Nerve Regeneration.

Applications

Unspecified application

Species

Unspecified reactive species

Guohu Di,Xia Qi,Xiaowen Zhao,Songmei Zhang,Patrik Danielson,Qingjun Zhou

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-GDNF Receptor alpha 1/GFRA1 antibody

Immunocytochemistry/ Immunofluorescence - Anti-GDNF Receptor alpha 1/GFRA1 antibody (AB186855)

Western blot - Anti-GDNF Receptor alpha 1/GFRA1 antibody (AB186855)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Product protocols

Target data

Publications (7)

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