JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB216667

Anti-GDNF Receptor alpha 1/GFRA1 antibody

Be the first to review this product! Submit a review

|

(1 Publication)

Rabbit Polyclonal GDNF Receptor alpha 1/GFRA1 antibody. Suitable for IHC-P and reacts with Rat, Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human GFRA1 aa 350-400 conjugated to Keyhole Limpet Haemocyanin.

View Alternative Names

GDNFRA, RETL1, TRNR1, GFRA1, GDNF family receptor alpha-1, GDNF receptor alpha-1, GDNFR-alpha-1, GFR-alpha-1, RET ligand 1, TGF-beta-related neurotrophic factor receptor 1

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GDNF Receptor alpha 1/GFRA1 antibody (AB216667)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GDNF Receptor alpha 1/GFRA1 antibody (AB216667)

Immunohistochemical analysis of formalin-fixed paraffin-embedded human colon carcinoma tissue, labeling GDNF Receptor alpha 1/GFRA1 using ab216667 at a 1/200 dilution, followed by conjugation to the secondary antibody and DAB staining.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GDNF Receptor alpha 1/GFRA1 antibody (AB216667)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GDNF Receptor alpha 1/GFRA1 antibody (AB216667)

Immunohistochemical analysis of formalin-fixed paraffin-embedded rat brain tissue, labeling GDNF Receptor alpha 1/GFRA1 using ab216667 at a 1/200 dilution, followed by conjugation to the secondary antibody and DAB staining.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Rat, Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human GFRA1 aa 350-400 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

P56159

Specificity

ab216667 exhibits a secondary cross-reactivity towards Exonuclease 1 due to a 60% contigueous sequence similarity over the immunogen range.

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." }, "Rat": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Preservative: 0.02% Proclin 300 Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
style
left-column
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

Coreceptor for GDNF, a neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake (PubMed : 10829012, PubMed : 31535977). GDNF-binding leads to autophosphorylation and activation of the RET receptor (PubMed : 31535977).
See full target information GFRA1
style
left-column

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

iScience 25:104813 PubMed35982785

2022

A microengineered Brain-Chip to model neuroinflammation in humans.

Applications

Unspecified application

Species

Unspecified reactive species

Iosif Pediaditakis,Konstantia R Kodella,Dimitris V Manatakis,Christopher Y Le,Sonalee Barthakur,Alexander Sorets,Achille Gravanis,Lorna Ewart,Lee L Rubin,Elias S Manolakos,Christopher D Hinojosa,Katia Karalis
View all publications
style
left-column
style
left-column
style
right-column

Alternative Products

Primary Antibodies

AB8026

Anti-GDNF Receptor alpha 1/GFRA1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GDNF Receptor alpha 1/GFRA1 antibody (AB8026)

  • 4
  • 2
Primary Antibodies

AB186855

Anti-GDNF Receptor alpha 1/GFRA1 antibody

Immunocytochemistry/ Immunofluorescence - Anti-GDNF Receptor alpha 1/GFRA1 antibody (AB186855)

  • 3
  • 1

Complementary Products

Assay Kits

AB309400

Human GDNF Receptor alpha/GFRA1 ELISA Kit

Sandwich ELISA - Human GDNF Receptor alpha/GFRA1 ELISA Kit (AB309400)

  • 0
  • 0
Primary Antibodies

AB176564

Anti-GDNF antibody [EPR2714(N)]

RabMAb|Recombinant

Flow Cytometry (Intracellular) - Anti-GDNF antibody [EPR2714(N)] (AB176564)

  • 5
  • 3
Primary Antibodies

AB108319

Anti-BDNF antibody [EPR1292]

BOND RX™ Validated|RabMAb|Recombinant|20ul selling size

Western blot - Anti-BDNF antibody [EPR1292] (AB108319)

  • 4
  • 9
Primary Antibodies

AB134100

Anti-Ret antibody [EPR2871]

RabMAb|Recombinant|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Ret antibody [EPR2871] (AB134100)

  • 4
  • 8
Primary Antibodies

AB52918

Anti-NGF antibody [EP1320Y]

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-NGF antibody [EP1320Y] (AB52918)

  • 4
  • 4

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com