AB8026

Anti-GDNF Receptor alpha 1/GFRA1 antibody

Name: Anti-GDNF Receptor alpha 1/GFRA1 antibody (ab8026) | Abcam
Brand: Abcam Limited
SKU: AB8026
Price: 670 USD
Availability: InStock
Rating: 4 (2 reviews)

(2 Reviews)

(23 Publications)

Rabbit Polyclonal GDNF Receptor alpha 1/GFRA1 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 23 publications.

View Alternative Names

GDNFRA, RETL1, TRNR1, GFRA1, GDNF family receptor alpha-1, GDNF receptor alpha-1, GDNFR-alpha-1, GFR-alpha-1, RET ligand 1, TGF-beta-related neurotrophic factor receptor 1

4 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GDNF Receptor alpha 1/GFRA1 antibody (AB8026)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GDNF Receptor alpha 1/GFRA1 antibody (AB8026)

Immunohistochemistry of human brain tissue staining GDNF Receptor alpha 1/GFRA1 using ab8026 at 2.5 μg/ml.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GDNF Receptor alpha 1/GFRA1 antibody (AB8026)

Immunohistochemistry of human brain tissue staining GDNF Receptor alpha 1/GFRA1 using ab8026 at 1 μg/ml.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GDNF Receptor alpha 1/GFRA1 antibody (AB8026)

Immunocytochemistry of human brain tissue staining GDNF Receptor alpha 1/GFRA1 using ab8026 at 20 μg/ml.

Unknown

Western blot - Anti-GDNF Receptor alpha 1/GFRA1 antibody (AB8026)

Western blot analysis of GFR alpha 1/GFRA1 in crude membrane fractions of human brain (B), liver (L), kidney (K), and spleen (S), respectively, with ab8026 at 1/500 dilution.

All lanes:

Western blot - Anti-GDNF Receptor alpha 1/GFRA1 antibody (ab8026) at 1/500 dilution

Lane 1:

Crude membrane fractions of human brain

Lane 2:

Crude membrane fractions of liver

Lane 3:

Crude membrane fractions of kidney

Lane 4:

Crude membrane fractions of spleen

Predicted band size: 51 kDa

Observed band size: 50 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1 µg/mL", "IHCP-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500", "WB-species-notes": "<p></p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification

Storage buffer

pH: 7.2 Preservative: 0.02% Sodium azide

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

+4°C

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Coreceptor for GDNF, a neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake (PubMed : 10829012, PubMed : 31535977). GDNF-binding leads to autophosphorylation and activation of the RET receptor (PubMed : 31535977).

See full target information GFRA1

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Publications (23)

Recent publications for all applications. Explore the full list and refine your search

Molecular therapy. Nucleic acids 35:102342 PubMed40207021

2025

Erratum: PAK1 Promotes the Proliferation and Inhibits Apoptosis of Human Spermatogonial Stem Cells via PDK1/KDR/ZNF367 and ERK1/2 and AKT Pathways.

Applications

Unspecified application

Species

Unspecified reactive species

Hongyong Fu,Wenhui Zhang,Qingqing Yuan,Minghui Niu,Fan Zhou,Qianqian Qiu,Guoping Mao,Hong Wang,Liping Wen,Min Sun,Zheng Li,Zuping He

Molecular biomedicine 5:71 PubMed39681821

2024

Metastasis-associated lung adenocarcinoma transcript 1 overexpression in testis contributes to idiopathic non-obstructive azoospermia via repressing ETS variant transcription factor 5.

Applications

Unspecified application

Species

Unspecified reactive species

Lei Wei,Zonggang Feng,Qian Dou,Pengfen Li,Xinghua Zhao,Bin Hao

The world journal of men's health 43:154-165 PubMed38606862

2024

Bisphenol Analogs Downregulate the Self-Renewal Potential of Spermatogonial Stem Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Seo-Hee Kim,Seung Hee Shin,Seok-Man Kim,Sang-Eun Jung,Beom-Jin Shin,Jin Seop Ahn,Kyoung Taek Lim,Dong-Hwan Kim,Kichoon Lee,Buom-Yong Ryu

iScience 27:109024 PubMed38352225

2024

KLF2 controls proliferation and apoptosis of human spermatogonial stem cells via targeting GJA1.

Applications

Unspecified application

Species

Unspecified reactive species

Wei Chen,Yinghong Cui,Chunyun Li,Caimei He,Li Du,Wei Liu,Zuping He

Frontiers in cell and developmental biology 10:883314 PubMed35676935

2022

Xenotransplantation of Human Spermatogonia Into Various Mouse Recipient Models.

Applications

Unspecified application

Species

Unspecified reactive species

Dongli Liang,Qi Sun,Zijue Zhu,Chuanyun Wang,Shicheng Ye,Zheng Li,Yuan Wang

Frontiers in cellular neuroscience 16:827628 PubMed35197829

2022

Long-Term Cultures of Spinal Cord Interneurons.

Applications

Unspecified application

Species

Unspecified reactive species

Ingrid Vargova,Jan Kriska,Jessica C F Kwok,James W Fawcett,Pavla Jendelova

Frontiers in pediatrics 9:795678 PubMed35096711

2022

Role of GDNF, GFRα1 and GFAP in a -Intervention Induced Mouse Model of Intestinal Neuronal Dysplasia.

Applications

Unspecified application

Species

Unspecified reactive species

Wei Liu,Tingting Zhou,Jinqiu Tian,Xiaofang Yu,Chuantao Ren,Zengcai Cao,Peimin Hou,Qiangye Zhang,Aiwu Li

Andrology 10:340-353 PubMed34499811

2021

Autophagy modulation alleviates cryoinjury in murine spermatogonial stem cell cryopreservation.

Applications

Unspecified application

Species

Unspecified reactive species

Sang-Eun Jung,Jin Seop Ahn,Yong-Hee Kim,Hui-Jo Oh,Bang-Jin Kim,Sun-Uk Kim,Buom-Yong Ryu

Antioxidants (Basel, Switzerland) 10: PubMed34068575

2021

Antioxidant or Apoptosis Inhibitor Supplementation in Culture Media Improves Post-Thaw Recovery of Murine Spermatogonial Stem Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Sang-Eun Jung,Hui-Jo Oh,Jin-Seop Ahn,Yong-Hee Kim,Bang-Jin Kim,Buom-Yong Ryu

Biopreservation and biobanking 19:493-502 PubMed33926212

2021

Inhibition of Caspase-8 Activity Improves Freezing Efficiency of Male Germline Stem Cells in Mice.

Applications

Unspecified application

Species

Unspecified reactive species

Sang-Eun Jung,Jin Seop Ahn,Yong-Hee Kim,Seok-Man Kim,Tea Gun Um,Bang-Jin Kim,Buom-Yong Ryu

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-GDNF Receptor alpha 1/GFRA1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GDNF Receptor alpha 1/GFRA1 antibody (AB8026)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GDNF Receptor alpha 1/GFRA1 antibody (AB8026)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GDNF Receptor alpha 1/GFRA1 antibody (AB8026)

Western blot - Anti-GDNF Receptor alpha 1/GFRA1 antibody (AB8026)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Product protocols

Target data

Publications (23)

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