AB8027

Anti-GDNF Receptor alpha 2/GFRA2 antibody

Name: Anti-GDNF Receptor alpha 2/GFRA2 antibody (ab8027) | Abcam
Brand: Abcam Limited
SKU: AB8027
Price: 545 USD
Availability: InStock

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(5 Publications)

Rabbit Polyclonal GDNF Receptor alpha 2/GFRA2 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 5 publications.

View Alternative Names

GDNFRB, RETL2, TRNR2, GFRA2, GDNF family receptor alpha-2, GDNF receptor alpha-2, GDNFR-alpha-2, GFR-alpha-2, GDNF receptor beta, Neurturin receptor alpha, RET ligand 2, TGF-beta-related neurotrophic factor receptor 2, GDNFR-beta, NRTNR-alpha, NTNR-alpha

2 Images

Immunocytochemistry/ Immunofluorescence - Anti-GDNF Receptor alpha 2/GFRA2 antibody (AB8027)

ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-GDNF Receptor alpha 2/GFRA2 antibody (AB8027)

ab8027 at 5μg/ml staining GDNF Receptor alpha2/GFRA2 in Hela cells by ICC/IF.

Unknown

Western blot - Anti-GDNF Receptor alpha 2/GFRA2 antibody (AB8027)

All lanes:

Western blot - Anti-GDNF Receptor alpha 2/GFRA2 antibody (ab8027) at 1/1000 dilution

All lanes:

HeLa total cell lysate

Predicted band size: 52 kDa

Observed band size: 52 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

WB, ICC/IF

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "5 µg/mL", "ICCIF-species-notes": "<p></p>" } } }

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Product details

Members of the glial cell line-derived neurotrophic factor(GDNF) family, including GDNF and neurturin (NTN),play key roles in the control of vertebrate neuron survivaland differentiation. Physiological responses to NTN requirethe presence of a novel glycosylphosphadidylinositollinked protein NTNRa, which is a cell surface receptor forNTN. The cDNAs encoding NTNRa from human, rat,chicken, and mouse have been cloned recently. NTNRa was also termed GDNFRb, Ret ligand 2 (RETL2)or TGF-b-related neurotrophic factor receptor 2 (TrnR2) and nominated as GFRa-2 recently. GFRa-2 binds NTN and mediates activation of RET receptor tyrosine kinase by both NTN and GDNF. Thus, NTN, GFRa-2, and the Ret PTK form a complex to transduce NTN signal andto mediate NTN function.

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Properties and storage information

Form

Liquid

Purification technique

Ion exchange chromatography

Storage buffer

pH: 7.2 Preservative: 0.02% Sodium azide

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

+4°C

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Receptor for neurturin (NRTN), a growth factor that supports the survival of sympathetic neurons (PubMed : 10829012, PubMed : 29414779, PubMed : 31535977, PubMed : 9182803). NRTN-binding leads to autophosphorylation and activation of the RET receptor (PubMed : 31535977). Also able to mediate GDNF signaling through the RET tyrosine kinase receptor (PubMed : 9182803).. Isoform 2. Participates in NRTN-induced 'Ser-727' phosphorylation of STAT3.

See full target information GFRA2

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Publications (5)

Recent publications for all applications. Explore the full list and refine your search

PloS one 14:e0216527 PubMed31107888

2019

The evolution and multi-molecular properties of NF1 cutaneous neurofibromas originating from C-fiber sensory endings and terminal Schwann cells at normal sites of sensory terminations in the skin.

Applications

Unspecified application

Species

Unspecified reactive species

Frank L Rice,George Houk,James P Wymer,Sara J C Gosline,Justin Guinney,Jianqiang Wu,Nancy Ratner,Michael P Jankowski,Salvo La Rosa,Marilyn Dockum,James R Storey,Steven L Carroll,Phillip J Albrecht,Vincent M Riccardi

Biochemical and biophysical research communication 510:339-344 PubMed30722993

2019

GDNF family receptor alpha 2 promotes neuroblastoma cell proliferation by interacting with PTEN.

Applications

Unspecified application

Species

Unspecified reactive species

Zuoqing Li,Juntao Xie,Yingchun Fei,Pengfei Gao,Qigen Xie,Wenzong Gao,Zhe Xu

Clinical cancer research : an official journal of the American Association for Cancer Research 20:140-150 PubMed24150232

2013

Transient activation of hedgehog pathway rescued irradiation-induced hyposalivation by preserving salivary stem/progenitor cells and parasympathetic innervation.

Applications

Unspecified application

Species

Unspecified reactive species

Bo Hai,Lizheng Qin,Zhenhua Yang,Qingguo Zhao,Lei Shangguan,Xinyu Ti,Yanqiu Zhao,Sangroh Kim,Dharanipathy Rangaraj,Fei Liu

Carcinogenesis 35:103-13 PubMed24067900

2013

The neurotrophic factor neurturin contributes toward an aggressive cancer cell phenotype, neuropathic pain and neuronal plasticity in pancreatic cancer.

Applications

IHC

Species

Human

Kun Wang,Ihsan Ekin Demir,Jan G D'Haese,Elke Tieftrunk,Kristina Kujundzic,Stephan Schorn,Baocai Xing,Timo Kehl,Helmut Friess,Güralp O Ceyhan

International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 23:425-38 PubMed16002253

2005

Ret, GFRalpha-1, GFRalpha-2 and GFRalpha-3 receptors in the human hippocampus and fascia dentata.

Applications

Unspecified application

Species

Unspecified reactive species

Maria Pina Serra,Marina Quartu,Francesca Mascia,Annalisa Manca,Marianna Boi,M Giuseppina Pisu,Maria Letizia Lai,Marina Del Fiacco

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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Anti-GDNF Receptor alpha 2/GFRA2 antibody

Immunocytochemistry/ Immunofluorescence - Anti-GDNF Receptor alpha 2/GFRA2 antibody (AB8027)

Western blot - Anti-GDNF Receptor alpha 2/GFRA2 antibody (AB8027)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

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Reactivity data

Product details

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Product protocols

Target data

Publications (5)

Product promise