AB33886

Anti-General Receptor for phosphoinositides 1/GRASP antibody [EP394Y]

RabMAb
Recombinant
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(2 Publications)

Rabbit Recombinant Monoclonal General Receptor for phosphoinositides 1/GRASP antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications.

View Alternative Names

GRASP, TAMALIN, Protein TAMALIN, General receptor for phosphoinositides 1-associated scaffold protein, GRP1-associated scaffold protein

1 Images

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Western blot - Anti-General Receptor for phosphoinositides 1/GRASP antibody [EP394Y] (AB33886)

All lanes:

Western blot - Anti-General Receptor for phosphoinositides 1/GRASP antibody [EP394Y] (ab33886) at 1/500 dilution

All lanes:

Human brain lysate

Predicted band size: 43 kDa

Observed band size: 45 kDa

false

Carrier free

Anti-General Receptor for phosphoinositides 1/GRASP antibody [EP394Y] - BSA and Azide free

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EP394Y

Isotype

IgG

Carrier free

Reacts with

Human

Applications

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "IHC" : {"fullname" : "Immunohistochemistry", "shortname":"IHC"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "IHC-species-checked": "notRecommended", "IHC-species-dilution-info": "", "IHC-species-notes": "", "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500", "WB-species-notes": "" }, "Mouse": { "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "IHC-species-checked": "notRecommended", "IHC-species-dilution-info": "", "IHC-species-notes": "", "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "IHC-species-checked": "notRecommended", "IHC-species-dilution-info": "", "IHC-species-notes": "", "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }

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Product details

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A

Storage buffer

pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.05% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The General Receptor for Phosphoinositides 1 (GRASP) also known as GRP1 is a protein that functions as a phosphoinositide-binding protein and regulates cellular membrane dynamics. It has a mass of approximately 97 kDa. GRASP is expressed in various tissues with significant presence in the brain and immune cells. Mechanically GRASP interacts with phosphoinositides on cellular membranes which assists in membrane trafficking and signaling.

Biological function summary

GRASP has a role in modulating intracellular transport processes and is critical in endosomal trafficking. It operates as part of a larger complex that regulates the recycling of membranes and proteins within cells. GRASP aids in ensuring that the proteins and membranes reach their intended cellular destinations maintaining cellular homeostasis.

Pathways

The protein is an important participant in the phosphoinositide 3-kinase (PI3K) signaling pathway an important pathway in cell growth proliferation and survival. GRASP interacts with proteins such as ARF6 influencing membrane dynamics and cellular signaling. Involved in these pathways GRASP contributes to proper cellular responses to extracellular signals and impacts various downstream biological effects.

GRASP plays a critical role in neurological disorders and immune system irregularities. Disruptions in GRASP function can be associated with conditions like Parkinson's disease and systemic lupus erythematosus (SLE). In Parkinson's GRASP interacts with proteins like LRRK2 suggesting a link between phosphoinositide signaling and neurodegenerative pathogenesis. In the immune context alterations in GRASP function seem connected to immune cell signaling irregularities influencing SLE development.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Plays a role in intracellular trafficking and contributes to the macromolecular organization of group 1 metabotropic glutamate receptors (mGluRs) at synapses.

See full target information TAMALIN

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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Science immunology 6: PubMed33649101

2021

Bispecific antibodies targeting mutant neoantigens.

Applications

Unspecified application

Species

Unspecified reactive species

Jacqueline Douglass,Emily Han-Chung Hsiue,Brian J Mog,Michael S Hwang,Sarah R DiNapoli,Alexander H Pearlman,Michelle S Miller,Katharine M Wright,P Aitana Azurmendi,Qing Wang,Suman Paul,Annika Schaefer,Andrew D Skora,Marco Dal Molin,Maximilian F Konig,Qiang Liu,Evangeline Watson,Yana Li,Michael B Murphy,Drew M Pardoll,Chetan Bettegowda,Nickolas Papadopoulos,Sandra B Gabelli,Kenneth W Kinzler,Bert Vogelstein,Shibin Zhou

Journal of cellular physiology : PubMed30779348

2019

The overexpression of GRASP might inhibit cell proliferation and invasion in hepatocellular carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Yang Cheng,Baobing Yin,Tianlu Hou,Tianyang Chen,Jian Ping

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-General Receptor for phosphoinositides 1/GRASP antibody [EP394Y]

Western blot - Anti-General Receptor for phosphoinositides 1/GRASP antibody [EP394Y] (AB33886)

Related conjugates and formulations (1)

Key facts

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Immunogen

Complementary Products

Primary Antibodies

Secondary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity data

Product details

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (2)

Product promise