Anti-Gentamicin antibody

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Biological function summary

The main activity of this antibiotic disrupts the normal function of the bacterial ribosome. It is not a part of a complex but interacts with the ribosome complex consisting of ribosomal RNA and various ribosomal proteins. By binding to the 30S subunit gentamicin causes errors in the translation process preventing the bacteria from synthesizing necessary proteins needed for growth and proliferation.

Pathways

Disruptions caused by gentamicin impact the bacterial translation pathway significantly. It affects the elongation cycle of protein synthesis where aminoacyl-tRNA enters the ribosomal A site. The faulty incorporation of amino acids due to gentamicin's effect hinders the elongation pathway leading to nonfunctional proteins and bacterial death. This process relates components like other aminoglycoside antibiotics such as amikacin which function similarly.