AB16997

Anti-GFAP antibody - Astrocyte Marker

Name: Anti-GFAP antibody - Astrocyte Marker (ab16997) | Abcam
Brand: Abcam Limited
SKU: AB16997
Price: 450 USD
Availability: InStock
Rating: 4 (1 reviews)

(1 Review)

(74 Publications)

Rabbit Polyclonal GFAP antibody. Suitable for ICC, IHC-P and reacts with Mouse, Human samples. Cited in 74 publications. Immunogen corresponding to Native Full Length Protein corresponding to Cow GFAP.

View Alternative Names

Glial fibrillary acidic protein, GFAP

3 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GFAP antibody - Astrocyte Marker (AB16997)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GFAP antibody - Astrocyte Marker (AB16997)

Formalin-fixed, paraffin-embedded section of human brain stained with antibodies to GFAP. Cytoplasmic staining of glia is shown in red.

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GFAP antibody - Astrocyte Marker (AB16997)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded human brain tissue, staining GFAP with ab16997.

Collaborator

Immunocytochemistry - Anti-GFAP antibody - Astrocyte Marker (AB16997)

Mouse cortical primary astrocytes stained for GFAP using ab16997 at a dilution of 1/100 in ICC/IF.

Photo courtesy of QBMCellScience

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Mouse, Human

Applications

ICC, IHC-P

applications

Immunogen

Native Full Length Protein corresponding to Cow GFAP.

Q28115

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICC" : {"fullname" : "Immunocytochemistry", "shortname":"ICC"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICC-species-checked": "guaranteed", "ICC-species-dilution-info": "", "ICC-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/250", "IHCP-species-notes": "<p></p>" }, "Mouse": { "ICC-species-checked": "testedAndGuaranteed", "ICC-species-dilution-info": "1/100", "ICC-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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Product details

In the central nervous system, this antibody stains astrocytes and some groups of ependymal cells. However, in the peripheral nervous system, it stains Schwann cells, satellite cells and enteric glial cells.

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Properties and storage information

Form

Liquid

Purity

IgG fraction

Storage buffer

pH: 7.3 - 7.5 Preservative: 0.05% Sodium azide Constituents: 1% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Storage information

Avoid freeze / thaw cycle

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells.

See full target information GFAP

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Publications (74)

Recent publications for all applications. Explore the full list and refine your search

Basic and clinical neuroscience 16:19-30 PubMed40655080

2025

L-α-aminoadipic Acid-induced Astrocytes Inhibition in the Hippocampal CA1 Region, Anxiety-like Behavior, and Memory Impairment.

Applications

Unspecified application

Species

Unspecified reactive species

Mehrdad Jahanshahi,Leila Elyasi,Emsehgol Nikmahzar

Communications medicine 5:29 PubMed39870870

2025

Preclinical use of a clinically-relevant scAAV9/SUMF1 vector for the treatment of multiple sulfatase deficiency.

Applications

Unspecified application

Species

Unspecified reactive species

Maximiliano Presa,Rachel M Bailey,Somdatta Ray,Lauren Bailey,Saurabh Tata,Tara Murphy,Pierre-Alexandre Piec,Harold Combs,Steven J Gray,Cathleen Lutz

Communications medicine 4:215 PubMed39448727

2024

Bone marrow transplantation increases sulfatase activity in somatic tissues in a multiple sulfatase deficiency mouse model.

Applications

Unspecified application

Species

Unspecified reactive species

Maximiliano Presa,Vi Pham,Somdatta Ray,Pierre-Alexandre Piec,Jennifer Ryan,Timothy Billings,Harold Coombs,Lars Schlotawa,Troy Lund,Rebecca C Ahrens-Nicklas,Cathleen Lutz

ACS biomaterials science & engineering 10:6545-6557 PubMed39259933

2024

Development of Tissue-Engineered Model of Fibrotic Scarring after Spinal Cord Injury to Study Astrocyte Activation and Neurite Outgrowth In Vitro.

Applications

Unspecified application

Species

Unspecified reactive species

Nikolas Ala-Kokko,Inha Baek,Younghye Song

Journal of neuroinflammation 21:161 PubMed38915059

2024

Astrocytic stress response is induced by exposure to astrocyte-binding antibodies expressed by plasmablasts from pediatric patients with acute transverse myelitis.

Applications

Unspecified application

Species

Unspecified reactive species

Chad Smith,Kiel M Telesford,Sara G M Piccirillo,Yamhilette Licon-Munoz,Wei Zhang,Key M Tse,Jacqueline R Rivas,Chaitanya Joshi,Dilan S Shah,Angela X Wu,Ritu Trivedi,Scott Christley,Yu Qian,Lindsay G Cowell,Richard H Scheuermann,Ann M Stowe,Linda Nguyen,Benjamin M Greenberg,Nancy L Monson

PloS one 19:e0299534 PubMed38574297

2024

Microdose lithium improves behavioral deficits and modulates molecular mechanisms of memory formation in female SAMP-8, a mouse model of accelerated aging.

Applications

Unspecified application

Species

Unspecified reactive species

Arthur Antonio Ruiz Pereira,Alessandra Macedo Pinto,Helena Nascimento Malerba,Mariana Toricelli,Hudson Sousa Buck,Tania Araujo Viel

Frontiers in cellular neuroscience 18:1336439 PubMed38486710

2024

MicroRNAs dysregulated in multiple sclerosis affect the differentiation of CG-4 cells, an oligodendrocyte progenitor cell line.

Applications

Unspecified application

Species

Unspecified reactive species

Océane Perdaens,Pauline Bottemanne,Vincent van Pesch

Frontiers in oncology 13:1253659 PubMed37817770

2023

Single-cell RNA sequencing of neurofibromas reveals a tumor microenvironment favorable for neural regeneration and immune suppression in a neurofibromatosis type 1 porcine model.

Applications

Unspecified application

Species

Unspecified reactive species

Dalton T McLean,Jennifer J Meudt,Loren D Lopez Rivera,Dominic T Schomberg,Derek M Pavelec,Tyler T Duellman,Darya G Buehler,Patrick B Schwartz,Melissa Graham,Laura M Lee,Keri D Graff,Jamie L Reichert,Sandra S Bon-Durant,Charles M Konsitzke,Sean M Ronnekleiv-Kelly,Dhanansayan Shanmuganayagam,C Dustin Rubinstein

Brain communications 5:fcad218 PubMed37601407

2023

Neuron-binding antibody responses are associated with Black ethnicity in multiple sclerosis during natalizumab treatment.

Applications

Unspecified application

Species

Unspecified reactive species

Kiel M Telesford,Chad Smith,Marcel Mettlen,Melissa B Davis,Lindsay Cowell,Rick Kittles,Timothy Vartanian,Nancy Monson

International journal of molecular sciences 24: PubMed37176001

2023

Severity- and Time-Dependent Activation of Microglia in Spinal Cord Injury.

Applications

Unspecified application

Species

Unspecified reactive species

Elvira Ruslanovna Akhmetzyanova,Margarita Nikolaevna Zhuravleva,Anna Viktorovna Timofeeva,Leisan Gazinurovna Tazetdinova,Ekaterina Evgenevna Garanina,Albert Anatolevich Rizvanov,Yana Olegovna Mukhamedshina

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-GFAP antibody - Astrocyte Marker

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GFAP antibody - Astrocyte Marker (AB16997)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GFAP antibody - Astrocyte Marker (AB16997)

Immunocytochemistry - Anti-GFAP antibody - Astrocyte Marker (AB16997)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

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Reactivity data

Product details

Properties and storage information

Form

Purity

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Storage information

Product protocols

Target data

Publications (74)

Product promise