Rabbit Recombinant Monoclonal GGCX antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 2 publications.
Images
![Immunocytochemistry/ Immunofluorescence - Anti-GGCX antibody [EPR11632] (AB170921), expandable thumbnail](https://content.abcam.com/products/images/ggcx-antibody-epr11632-ab170921--immunocytochemistry-immunofluorescence-img79618.jpg/_jcr_content/renditions/webp-475.webp "Immunocytochemistry/ Immunofluorescence - Anti-GGCX antibody [EPR11632] (AB170921)")
![Western blot - Anti-GGCX antibody [EPR11632] (AB170921), expandable thumbnail](https://content.abcam.com/products/images/ggcx-antibody-epr11632-ab170921--western-blot-img116841.jpg/_jcr_content/renditions/webp-475.webp "Western blot - Anti-GGCX antibody [EPR11632] (AB170921)")
Publications
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- Human mutation 43:42-552021GGCX variants leading to biallelic deficiency to γ-carboxylate GRP cause skin laxity in VKCFD1 patients.Applications:Unspecified applicationReactive species:Unspecified reactive speciesSuvoshree Ghosh,Katrin Kraus,Arijit Biswas,Jens Müller,Francesco Forin,Heike Singer,Klara Höning,Veit Hornung,Matthias Watzka,Johannes Oldenburg,Katrin J Czogalla-NitschePubMed 34816548
- Journal of thrombosis and haemostasis : JTH 19:1412-14242021GGCX mutations show different responses to vitamin K thereby determining the severity of the hemorrhagic phenotype in VKCFD1 patients.Applications:Unspecified applicationReactive species:Unspecified reactive speciesSuvoshree Ghosh,Katrin Kraus,Arijit Biswas,Jens Müller,Anna-Lena Buhl,Francesco Forin,Heike Singer,Klara Höning,Veit Hornung,Matthias Watzka,Katrin J Czogalla-Nitsche,Johannes OldenburgPubMed 33590680
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.2 - 7.4
Preservative: 0.01% Sodium azide
Constituents: 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 9% PBS, 0.05% BSA- Form
- Liquid
- Clonality
- Monoclonal
Immunogen
- The exact immunogen used to generate this antibody is proprietary information.
Reactivity data
Select an application| IP | Flow Cyt | WB | IHC-P | ICC/IF | |
|---|---|---|---|---|---|
| Human | Not recommended | Not recommended | Tested | Not recommended | Tested |
| Mouse | Not recommended | Not recommended | Not recommended | Not recommended | Not recommended |
| Rat | Not recommended | Not recommended | Not recommended | Not recommended | Not recommended |
IP
Not recommendedNot recommended
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Rat, Human | Dilution info - | Notes - |
Flow Cyt
Not recommendedNot recommended
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Rat, Human | Dilution info - | Notes - |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/1000 - 1/10000 | Notes - |
Not recommendedNot recommended
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Rat | Dilution info - | Notes - |
IHC-P
Not recommendedNot recommended
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Rat, Human | Dilution info - | Notes - |
ICC/IF
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/100 - 1/250 | Notes - |
Not recommendedNot recommended
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Rat | Dilution info - | Notes - |
Associated Products
Select an associated product type
1 product for Alternative Product
Target data
Function
Mediates the vitamin K-dependent carboxylation of glutamate residues to calcium-binding gamma-carboxyglutamate (Gla) residues with the concomitant conversion of the reduced hydroquinone form of vitamin K to vitamin K epoxide (PubMed:17073445). Catalyzes gamma-carboxylation of various proteins, such as blood coagulation factors (F2, F7, F9 and F10), osteocalcin (BGLAP) or matrix Gla protein (MGP) (PubMed:17073445).
Alternative names
GC, GGCX, Vitamin K-dependent gamma-carboxylase, Gamma-glutamyl carboxylase, Peptidyl-glutamate 4-carboxylase, Vitamin K gamma glutamyl carboxylase
Recommended products
Rabbit Recombinant Monoclonal GGCX antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 2 publications.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.2 - 7.4
Preservative: 0.01% Sodium azide
Constituents: 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 9% PBS, 0.05% BSA- Form
- Liquid
- Clonality
- Monoclonal
- Immunogen
- The exact immunogen used to generate this antibody is proprietary information.
- Clone number
- EPR11632
- Purification technique
- Affinity purification Protein A
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
This product is a recombinant monoclonal antibody, which offers several advantages including:
- - High batch-to-batch consistency and reproducibility
- - Improved sensitivity and specificity
- - Long-term security of supply
- - Animal-free batch production
For more information, read more on recombinant antibodies.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
2 product images
![Immunocytochemistry/ Immunofluorescence - Anti-GGCX antibody [EPR11632] (ab170921), expandable thumbnail](https://content.abcam.com/products/images/ggcx-antibody-epr11632-ab170921--immunocytochemistry-immunofluorescence-img79618.jpg "Immunocytochemistry/ Immunofluorescence - Anti-GGCX antibody [EPR11632] (ab170921)")
Immunocytochemistry/ Immunofluorescence - Anti-GGCX antibody [EPR11632] (ab170921)
Immunofluorescent staining of HeLa cells labeling GGCX with ab170921 at 1/100 (green). DAPI nuclear staining (blue).
![Western blot - Anti-GGCX antibody [EPR11632] (ab170921), expandable thumbnail](https://content.abcam.com/products/images/ggcx-antibody-epr11632-ab170921--western-blot-img116841.jpg "Western blot - Anti-GGCX antibody [EPR11632] (ab170921)")
Western blot - Anti-GGCX antibody [EPR11632] (ab170921)
All lanes: Western blot - Anti-GGCX antibody [EPR11632] (ab170921) at 1/1000 dilution
Lane 1: Human placenta lysate at 10 µg
Lane 2: MCF7 cell lysate at 10 µg
Lane 3: 293T cell lysate at 10 µg
Lane 4: HeLa cell lysate at 10 µg
SecondaryAll lanes: Goat anti-rabbit HRP conjugated antibody at 1/2000 dilution
Developed using the ECL technique.
Predicted band size: 88 kDa
Downloads
Product protocols
- Visit the general protocols
- Visit troubleshooting
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