AB104307

Anti-Ghrelin antibody

Name: Anti-Ghrelin antibody (ab104307) | Abcam
Brand: Abcam Limited
SKU: AB104307
Price: 630 USD
Availability: InStock
Rating: 4 (5 reviews)

(5 Reviews)

(6 Publications)

Goat Polyclonal GHRL antibody. Suitable for IHC-P, ELISA and reacts with Human samples. Cited in 6 publications. Immunogen corresponding to Synthetic Peptide within Human GHRL aa 100 to C-terminus.

View Alternative Names

MTLRP, UNQ524/PRO1066, GHRL, Appetite-regulating hormone, Growth hormone secretagogue, Growth hormone-releasing peptide, Motilin-related peptide, Protein M46

2 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Ghrelin antibody (AB104307)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Ghrelin antibody (AB104307)

Formalin-fixed, paraffin-embedded Human Placenta stained with ab104307 at 2 ug/ml followed by biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Ghrelin antibody (AB104307)

Formalin-fixed, paraffin-embedded Human Colon stained with ab104307 at 2 ug/ml followed by biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Key facts

Host species

Goat

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

IHC-P, ELISA

applications

Immunogen

Synthetic Peptide within Human GHRL aa 100 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q9UBU3

Specificity

This antibody is expected to recognise all reported isoforms.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "2 µg/mL", "IHCP-species-notes": "<p></p>", "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ELISA-species-checked": "predicted", "ELISA-species-dilution-info": "", "ELISA-species-notes": "" }, "Rhesus monkey": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ELISA-species-checked": "predicted", "ELISA-species-dilution-info": "", "ELISA-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.3 Preservative: 0.02% Sodium azide Constituents: Tris buffered saline, 0.5% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Ghrelin also known as the "hunger hormone" or GH secretagogue is a peptide hormone with a mass of 28 amino acids. Ghrelin is mainly expressed in the stomach particularly in the enteroendocrine cells but it can also be found in small amounts in the lungs pancreas and hypothalamus. The hormone increases food intake and promotes fat storage by signaling the brain to stimulate hunger. Its secretion occurs in response to fasting and is suppressed by food intake reflecting its role in energy balance.

Biological function summary

Ghrelin influences a variety of physiological processes beyond hunger regulation. It plays a role in modulating the release of growth hormone by acting on the growth hormone secretagogue receptor (GHS-R). Ghrelin also affects gastric motility and acid secretion due to its expression in the gastrointestinal tract. Though not part of a larger complex its interaction with GHS-R strongly influences its biological functions. Ghrelin may also impact insulin secretion and sensitivity linking it to glucose metabolism processes.

Pathways

Ghrelin interacts with several critical biological networks. Ghrelin is involved in the neuroendocrine pathway that connects the gut to the brain and contributes significantly to energy homeostasis. Within this pathway it influences proteins like leptin which exerts opposite effects by suppressing hunger. Additionally ghrelin functions in the hedonic control of eating which relates to the rewarding aspects of food intake controlled by pathways involving dopamine.

Ghrelin holds relevance to obesity and cachexia a form of extreme weight loss often seen in chronic illness. Ghrelin promotes adiposity by stimulating appetite which can contribute to obesity. Conversely in cachexia the decrease in ghrelin activity is thought to exacerbate weight loss. Its role in energy balance associates ghrelin with the protein leptin which counterbalances its effects and connections to metabolic disorders. Understanding ghrelin’s functions and pathways provides insight into therapeutic strategies for these conditions.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Ghrelin-27. Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR) (PubMed : 10604470). Induces the release of growth hormone from the pituitary (PubMed : 10604470). Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation.. Ghrelin-28. Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR) (PubMed : 10604470). Induces the release of growth hormone from the pituitary (PubMed : 10604470). Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation.. Obestatin. May be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility (By similarity).

See full target information GHRL

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Publications (6)

Recent publications for all applications. Explore the full list and refine your search

Obesity (Silver Spring, Md.) 32:911-922 PubMed38558513

2024

Repeated photodynamic therapy using a chlorin e6-embedded device to prolong the therapeutic effects on obesity.

Applications

Unspecified application

Species

Unspecified reactive species

Jung-Hoon Park,Ji Won Kim,Dae Sung Ryu,Hyeonseung Lee,Hee Kyong Na,Jin Hee Noh,Do Hoon Kim,Sanghee Lee,Kun Na,Hwoon-Yong Jung

Scientific reports 13:20254 PubMed37985861

2023

Hypobaric hypoxia induces iron mobilization from liver and spleen and increases serum iron via activation of ghrelin/GHSR1a/MAPK signalling pathway in mice.

Applications

Unspecified application

Species

Unspecified reactive species

Wanping Yang,Jiayan Li,Jianan Hu,Xiaoyu Yuan,Jie Ding,Hui Jiang,Guohua Wang,Qianqian Luo

Science robotics 8:eade9676 PubMed37099636

2023

Bioinspired, ingestible electroceutical capsules for hunger-regulating hormone modulation.

Applications

Unspecified application

Species

Unspecified reactive species

Khalil B Ramadi,James C McRae,George Selsing,Arnold Su,Rafael Fernandes,Maela Hickling,Brandon Rios,Sahab Babaee,Seokkee Min,Declan Gwynne,Neil Zixun Jia,Aleyah Aragon,Keiko Ishida,Johannes Kuosmanen,Josh Jenkins,Alison Hayward,Ken Kamrin,Giovanni Traverso

Nutrients 12: PubMed32824949

2020

The Effect of High-Fat Diet-Induced Obesity on the Expression of Nutrient Chemosensors in the Mouse Stomach and the Gastric Ghrelin Cell.

Applications

Unspecified application

Species

Unspecified reactive species

Maria Nunez-Salces,Hui Li,Stewart Christie,Amanda J Page

Neurogastroenterology and motility 32:e13944 PubMed32666613

2020

Nutrient-sensing components of the mouse stomach and the gastric ghrelin cell.

Applications

Unspecified application

Species

Unspecified reactive species

Maria Nunez-Salces,Hui Li,Christine Feinle-Bisset,Richard L Young,Amanda J Page

Journal of orthopaedic research : official publica 37:1387-1397 PubMed30644571

2019

Enhancement of the chondrogenic differentiation of mesenchymal stem cells and cartilage repair by ghrelin.

Applications

Unspecified application

Species

Unspecified reactive species

Litong Fan,Jiaqing Chen,Yanmeng Tao,Boon Chin Heng,Jiakuo Yu,Zheng Yang,Zigang Ge

View all publications

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