Anti-Ghrelin (Ghrelin-28) antibody [EPR20502-47] - BSA and Azide free (Capture)

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

Ghrelin also known as Ghrelin-28 is a peptide hormone with a mass of approximately 3.3 kDa. It functions as an important regulator of appetite and energy balance. Ghrelin is secreted mainly by the stomach's enteroendocrine cells particularly the P/D1 cells in humans. In addition it is present in smaller amounts in the pancreas intestines and hypothalamus. The peptide is known for its ability to stimulate the release of growth hormone from the anterior pituitary gland acting via the growth hormone secretagogue receptor (GHS-R).

Biological function summary

Ghrelin plays a significant role in hunger signaling and energy homeostasis. It is not typically part of a protein complex but acts as a ligand for GHS-R. By binding to the receptor in the brain especially in the hypothalamus Ghrelin promotes food intake and can influence body weight regulation. The hormone also affects glucose metabolism and has impacts on cardiovascular functions. Its presence in the gastrointestinal tract suggests involvement in gastric motility and acid secretion.

Pathways

Ghrelin is notably involved in the GH/IGF-1 axis and the central nervous system pathways that regulate appetite. The ghrelin/GHS-R interaction engages pathways that include the AMP-activated protein kinase (AMPK) and mitogen-activated protein kinase (MAPK) which contribute to its metabolic effects. Ghrelin also interacts with proteins such as leptin and insulin both of which play important roles in energy and glucose homeostasis creating a complex interplay that influences overall metabolic state.

Associated diseases and disorders

Ghrelin has been linked to obesity and cachexia. Elevated levels of Ghrelin can lead to increased appetite and weight gain making it relevant for obesity research. Conversely reduced Ghrelin activity may contribute to conditions like cachexia where there is significant weight loss and muscle wasting as seen in cancer patients. Alterations in Ghrelin expression or function can also impact insulin levels connecting it to diabetes-related conditions. Understanding Ghrelin's interactions with proteins like leptin and insulin provides insights into potential therapeutic strategies for managing these metabolic disorders.