AB150514

Anti-Ghrelin Receptor/GHS-R antibody

Name: Anti-Ghrelin Receptor/GHS-R antibody (ab150514) | Abcam
Brand: Abcam Limited
SKU: AB150514
Price: 630 USD
Availability: InStock

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(2 Publications)

Rabbit Polyclonal Ghrelin Receptor/GHS-R antibody. Suitable for IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human Growth hormone secretagogue receptor type 1.

View Alternative Names

Growth hormone secretagogue receptor type 1, GHS-R, GH-releasing peptide receptor, Ghrelin receptor, GHRP, GHSR

1 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Ghrelin Receptor/GHS-R antibody (AB150514)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Ghrelin Receptor/GHS-R antibody (AB150514)

Immunohistochemistry of formalin-fixed, paraffin-embedded Human pituitary anterior tissue labelling Ghrelin Receptor/GHS-R with ab150514 at 5 μg/ml.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human Growth hormone secretagogue receptor type 1. The exact immunogen used to generate this antibody is proprietary information.

Q92847

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5-7.5 µg/mL", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval before commencing with IHC staining protocol." }, "Common marmoset": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Gorilla": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Monkey": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.4 Preservative: 0.1% Sodium azide Constituents: 99% PBS

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The Ghrelin Receptor also known as GHS-R or GHSR is a G protein-coupled receptor responsible for binding ghrelin the hunger hormone which is a ligand composed of ghrelin peptides. The receptor weighing approximately 44 kDa exhibits a chemical structure typical for G-protein-coupled receptors which enables signal transduction across cell membranes. The receptor is expressed extensively in the hypothalamus pituitary gland and other peripheral tissues including heart and adipose tissue indicating its widespread role in energy homeostasis.

Biological function summary

This target modulates several physiological processes. It notably has a significant influence on appetite regulation and energy balance reflecting its function as part of the larger neuroendocrine system. The Ghrelin Receptor does not form a larger protein complex but interacts directly with ghrelin analogues to mediate its effects. This interaction plays a critical role in stimulating growth hormone release influencing metabolic processes.

Pathways

The Ghrelin Receptor is integral to the growth hormone secretagogue pathway where it interacts closely with the growth hormone-releasing hormone receptor (GHRHR). This pathway exemplifies the receptor’s role in energy metabolism and regulation of body composition. In addition to this the receptor is involved in neuroendocrine signaling pathways impacting appetite and feeding behaviors by signaling to orexigenic neurons in the arcuate nucleus of the hypothalamus.

Research indicates that dysregulation of Ghrelin Receptor activity is linked to obesity and metabolic syndromes. Alterations in ghrelin signaling can lead to abnormal energy balance and fat storage. Moreover the receptor is associated with conditions like Prader-Willi Syndrome where ghrelin levels commonly increase exacerbating feeding behaviors. The Ghrelin Receptor's relationship with the growth hormone and its dynamic interaction with GHRHR also highlight its broader relevance in metabolic and growth-related disorders.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
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Target data

Receptor for ghrelin, coupled to G-alpha-11 proteins. Stimulates growth hormone secretion. Binds also other growth hormone releasing peptides (GHRP) (e.g. Met-enkephalin and GHRP-6) as well as non-peptide, low molecular weight secretagogues (e.g. L-692,429, MK-0677, adenosine).

See full target information Growth hormone secretagogue receptor type 1

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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

World journal of gastrointestinal surgery 13:1708-1720 PubMed35070075

2022

Expression of adipokine ghrelin and ghrelin receptor in human colorectal adenoma and correlation with the grade of dysplasia.

Applications

Unspecified application

Species

Unspecified reactive species

Sanja Stojsavljevic-Shapeski,Lucija Virovic-Jukic,Davor Tomas,Marko Duvnjak,Vedran Tomasic,Davor Hrabar,Dominik Kralj,Ivan Budimir,Neven Barsic,Neven Ljubicic

Journal of dermatological science 92:143-150 PubMed30237006

2018

Neutrophils contribute to vasculitis by increased release of neutrophil extracellular traps in Behçet's disease.

Applications

Unspecified application

Species

Unspecified reactive species

Rémi Safi,Romy Kallas,Tara Bardawil,Carl Joe Mehanna,Ossama Abbas,Rola Hamam,Imad Uthman,Abdul-Ghani Kibbi,Dany Nassar

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Ghrelin Receptor/GHS-R antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Ghrelin Receptor/GHS-R antibody (AB150514)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (2)

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