Rabbit Polyclonal Ghrelin Receptor/GHS-R antibody. Suitable for WB, IHC-P and reacts with Rat, Human samples. Cited in 12 publications.
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- Frontiers in endocrinology 13:9327612022Involvement of POMC neurons in LEAP2 regulation of food intake and body weight.Applications:Unspecified applicationReactive species:Unspecified reactive speciesGuangpin Chu,Hualing Peng,Nana Yu,Yuejin Zhang,Xueling Lin,Yisheng LuPubMed 36387867
- International journal of molecular sciences 23:2022Ghrelin Represses Thymic Stromal Lymphopoietin Gene Expression through Activation of Glucocorticoid Receptor and Protein Kinase C Delta in Inflamed Skin Keratinocytes.Applications:Unspecified applicationReactive species:Unspecified reactive speciesHayan Jeong,Hyo-Jin Chong,Jangho So,Yejin Jo,Tae-Young Yune,Bong-Gun JuPubMed 35409338
- International journal of molecular sciences 23:2022Effect of Bacterial Infection on Ghrelin Receptor Regulation in Periodontal Cells and Tissues.Applications:Unspecified applicationReactive species:Unspecified reactive speciesAndressa V B Nogueira,Marjan Nokhbehsaim,Anna Damanaki,Sigrun Eick,Svenja Beisel-Memmert,Christian Kirschneck,Agnes Schröder,Thamiris Cirelli,Natalia D P Leguizamón,Joni A Cirelli,James DeschnerPubMed 35328456
- Molecular medicine reports 20:5050-50582019Effects of β‑hydroxybutyric acid and ghrelin on the motility and inflammation of gastric antral smooth muscle cells involving the regulation of growth hormone secretagogue receptor.Applications:Unspecified applicationReactive species:Unspecified reactive speciesXiaolin Hu et. al.PubMed 31638214
- American journal of physiology. Gastrointestinal a 316:G453-G4612019Chronic alcohol exposure alters circulating insulin and ghrelin levels: role of ghrelin in hepatic steatosis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesKaruna Rasineni et. al.PubMed 30702902
- Cell communication and signaling : CCS 17:82019Gut ghrelin regulates hepatic glucose production and insulin signaling via a gut-brain-liver pathway.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYao Lin,Zerong Liang,Liping He,Mengliu Yang,Dongfang Liu,Harvest F Gu,Hua Liu,Zhiming Zhu,Hongting Zheng,Ling Li,Gangyi YangPubMed 30683114
- Cell metabolism 27:461-469.e62017LEAP2 Is an Endogenous Antagonist of the Ghrelin Receptor.Applications:Unspecified applicationReactive species:Unspecified reactive speciesXuecai Ge,Hong Yang,Maria A Bednarek,Hadas Galon-Tilleman,Peirong Chen,Michael Chen,Joshua S Lichtman,Yan Wang,Olivier Dalmas,Yiyuan Yin,Hui Tian,Lutz Jermutus,Joseph Grimsby,Cristina M Rondinone,Anish Konkar,Daniel D KaplanPubMed 29233536
- Mediators of inflammation 2017:49169712017Regulation of Ghrelin Receptor by Periodontal Bacteria and .
- Polish journal of veterinary sciences 20:467-4752017Spirulina Platensis Affects Factors Involved in Spermatogenesis and Increases Ghrelin Receptors in Testis Tissue of Rats Fed a High-Fat Diet.Applications:Unspecified applicationReactive species:Unspecified reactive speciesO B B Esener,E Gurel-Gurevin,B Isbilen-Basok,F Yigit,T Bilal,A Altiner,N Yilmazer,E I ArmutakPubMed 29166288
- European journal of histochemistry : EJH 60:25572016Molecules implicated in glucose homeostasis are differentially expressed in the trachea of lean and obese Zucker rats.Applications:Unspecified applicationReactive species:Unspecified reactive speciesF Merigo et. al.PubMed 26972710
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
Preservative: 0.02% Sodium azide
Constituents: 2% BSA- Form
- Lyophilized
- Clonality
- Polyclonal
Immunogen
- The exact immunogen used to generate this antibody is proprietary information.
Reactivity data
Select an application| WB | IHC-P | |
|---|---|---|
| Human | Expected | Tested |
| Mouse | Predicted | Predicted |
| Rat | Tested | Expected |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Rat | Dilution info 1/200.00000 - 1/1000.00000 | Notes - |
ExpectedExpected
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info Use at an assay dependent concentration. | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info - | Notes - |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/100.00000 - 1/500.00000 | Notes - |
ExpectedExpected
| Species | Dilution info | Notes |
|---|---|---|
Species Rat | Dilution info Use at an assay dependent concentration. | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info - | Notes - |
Associated Products
Select an associated product type
2 products for Alternative Product
Target data
Function
Receptor for ghrelin, coupled to G-alpha-11 proteins. Stimulates growth hormone secretion. Binds also other growth hormone releasing peptides (GHRP) (e.g. Met-enkephalin and GHRP-6) as well as non-peptide, low molecular weight secretagogues (e.g. L-692,429, MK-0677, adenosine).
Alternative names
Growth hormone secretagogue receptor type 1, GHS-R, GH-releasing peptide receptor, Ghrelin receptor, GHRP, GHSR
Recommended products
Rabbit Polyclonal Ghrelin Receptor/GHS-R antibody. Suitable for WB, IHC-P and reacts with Rat, Human samples. Cited in 12 publications.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
Preservative: 0.02% Sodium azide
Constituents: 2% BSA- Form
- Lyophilized
- Clonality
- Polyclonal
- Immunogen
- The exact immunogen used to generate this antibody is proprietary information.
- Purification technique
- Affinity purification Immunogen
- Reconstitution
- reconstitute with water at 200µL
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
The Ghrelin Receptor also known as GHS-R or GHSR is a G protein-coupled receptor responsible for binding ghrelin the hunger hormone which is a ligand composed of ghrelin peptides. The receptor weighing approximately 44 kDa exhibits a chemical structure typical for G-protein-coupled receptors which enables signal transduction across cell membranes. The receptor is expressed extensively in the hypothalamus pituitary gland and other peripheral tissues including heart and adipose tissue indicating its widespread role in energy homeostasis.
- Biological function summary
This target modulates several physiological processes. It notably has a significant influence on appetite regulation and energy balance reflecting its function as part of the larger neuroendocrine system. The Ghrelin Receptor does not form a larger protein complex but interacts directly with ghrelin analogues to mediate its effects. This interaction plays a critical role in stimulating growth hormone release influencing metabolic processes.
- Pathways
The Ghrelin Receptor is integral to the growth hormone secretagogue pathway where it interacts closely with the growth hormone-releasing hormone receptor (GHRHR). This pathway exemplifies the receptor’s role in energy metabolism and regulation of body composition. In addition to this the receptor is involved in neuroendocrine signaling pathways impacting appetite and feeding behaviors by signaling to orexigenic neurons in the arcuate nucleus of the hypothalamus.
- Associated diseases and disorders
Research indicates that dysregulation of Ghrelin Receptor activity is linked to obesity and metabolic syndromes. Alterations in ghrelin signaling can lead to abnormal energy balance and fat storage. Moreover the receptor is associated with conditions like Prader-Willi Syndrome where ghrelin levels commonly increase exacerbating feeding behaviors. The Ghrelin Receptor's relationship with the growth hormone and its dynamic interaction with GHRHR also highlight its broader relevance in metabolic and growth-related disorders.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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2 product images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Ghrelin Receptor/GHS-R antibody (ab85104)
ab85104 at 1/200 dilution staining Ghrelin Receptor/GHS-R in human fetal brain tissue section by immunohistochemistry (Formalin/ PFA fixed, paraffin-embedded tissue sections).
Western blot - Anti-Ghrelin Receptor/GHS-R antibody (ab85104)
Rat liver lysate, 1:500 dilution.
All lanes: Western blot - Anti-Ghrelin Receptor/GHS-R antibody (ab85104)
Predicted band size: 41 kDa
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