Rabbit Polyclonal GHRHR antibody. Suitable for IHC-P and reacts with Human samples. Cited in 27 publications. Immunogen corresponding to Synthetic Peptide within Human Growth hormone-releasing hormone receptor aa 400 to C-terminus conjugated to Keyhole Limpet Haemocyanin.
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Publications
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- Proceedings of the National Academy of Sciences of the United States of America 120:e22168141202023Agonist of growth hormone-releasing hormone improves the disease features of spinal muscular atrophy mice.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMarina Boido,Iacopo Gesmundo,Anna Caretto,Francesca Pedrolli,Roberta Schellino,Sheila Leone,Renzhi Cai,Wei Sha,Ezio Ghigo,Andrew V Schally,Alessandro Vercelli,Riccarda GranataPubMed 36603028
- Endocrines 3:813-8202022Growth Hormone-Releasing Hormone Antagonist JV-1-36 Suppresses Reactive Oxygen Species Generation in A549 Lung Cancer Cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesKhadeja-Tul Kubra,Mohammad S Akhter,Kaitlyn Apperley,Nektarios BarabutisPubMed 36540765
- Journal of biochemical and molecular toxicology 35:e228792021Suppression of reactive oxygen species in endothelial cells by an antagonist of growth hormone-releasing hormone.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMohammad S Akhter,Nektarios BarabutisPubMed 34369038
- Hormone and metabolic research = Hormon- und Stoff 52:336-3392020GHRH Antagonists Protect Against Hydrogen Peroxide-Induced Breakdown of Brain Microvascular Endothelium Integrity.Applications:Unspecified applicationReactive species:Unspecified reactive speciesNektarios Barabutis et. al.PubMed 32403147
- International journal of molecular sciences 21:2020Thyrotropin-Releasing Hormone (TRH) and Somatostatin (SST), but not Growth Hormone-Releasing Hormone (GHRH) nor Ghrelin (GHRL), Regulate Expression and Release of Immune Growth Hormone (GH) from Chicken Bursal B-Lymphocyte Cultures.Applications:Unspecified applicationReactive species:Unspecified reactive speciesSantiago Pech-Pool et. al.PubMed 32093298
- Tissue barriers 7:16699892019GHRH antagonists support lung endothelial barrier function.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMohammad A Uddin et. al.PubMed 31578921
- Human mutation 40:2033-20432019Contribution of functionally assessed GHRHR mutations to idiopathic isolated growth hormone deficiency in patients without GH1 mutations.Applications:Unspecified applicationReactive species:Unspecified reactive speciesEnzo Cohen et. al.PubMed 31231873
- Experimental eye research 181:277-2842019Growth hormone-releasing hormone receptor mediates cytokine production in ciliary and iris epithelial cells during LPS-induced ocular inflammation.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJia Lin Ren et. al.PubMed 30831084
- Investigative ophthalmology & visual science 59:5060-50662018Induction of Apoptosis in Pterygium Cells by Antagonists of Growth Hormone-Releasing Hormone Receptors.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYong Jie Qin,Wai Kit Chu,Li Huang,Clara Hoi Yen Ng,Tommy Chung Yan Chan,Di Cao,Cheng Yang,Liang Zhang,Shao Ping Huang,Juan Li,Hong Liang Lin,Wen Qian Li,Li Chen,Andrew V Schally,Sun On Chan,Hong Yang Zhang,Chi Pui PangPubMed 30357400
- British journal of haematology 181:476-4852018A new approach to the treatment of acute myeloid leukaemia targeting the receptor for growth hormone-releasing hormone.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJoaquin J Jimenez et. al.PubMed 29663325
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
Preservative: 0.05% Sodium azide
Constituents: Whole serum- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Human Growth hormone-releasing hormone receptor aa 400 to C-terminus conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information. Database link Q02643
Reactivity data
Select an application| IHC-P | |
|---|---|
| Human | Tested |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/1000 | Notes Perform heat mediated antigen retrieval via the microwave method for 20 minutes in citric acid at pH 6.0. Perform heat-mediated antigen retrieval via the microwave method before commencing with IHC staining protocol. |
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Target data
Function
Receptor for GRF, coupled to G proteins which activate adenylyl cyclase. Stimulates somatotroph cell growth, growth hormone gene transcription and growth hormone secretion.
Alternative names
Growth hormone-releasing hormone receptor, GHRH receptor, Growth hormone-releasing factor receptor, GRF receptor, GRFR, GHRHR
Recommended products
Rabbit Polyclonal GHRHR antibody. Suitable for IHC-P and reacts with Human samples. Cited in 27 publications. Immunogen corresponding to Synthetic Peptide within Human Growth hormone-releasing hormone receptor aa 400 to C-terminus conjugated to Keyhole Limpet Haemocyanin.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
Preservative: 0.05% Sodium azide
Constituents: Whole serum- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Human Growth hormone-releasing hormone receptor aa 400 to C-terminus conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information. Database link Q02643
- Purity
- Whole antiserum
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
GHRHR also known as the growth hormone-releasing hormone receptor is an important protein that plays an important role mechanistically in the human body. This receptor is located on the cell membrane and binds to growth hormone-releasing hormone (GHRH). GHRHR is expressed predominantly in the pituitary gland. It has a molecular mass of approximately 44 kDa and its activation leads to the intracellular signaling cascades that promote growth hormone secretion.
- Biological function summary
The interaction of GHRHR with GHRH is necessary for the regulation of growth hormone release. This receptor is not part of a larger complex; instead it functions individually as a receptor. GHRHR's role in stimulating growth hormone release makes it essential for normal growth metabolism and body composition. It influences processes like protein synthesis lipolysis and the maintenance of normal glucose levels.
- Pathways
GHRHR operates within the growth hormone signaling pathway. This pathway involves the activation of GHRHR by GHRH which leads to the stimulation of adenylate cyclase increasing cyclic AMP levels resulting in growth hormone release. This pathway is interconnected with other signaling proteins like somatostatin which acts as an inhibitor of growth hormone secretion providing a balance in growth regulation.
- Associated diseases and disorders
GHRHR has been linked to conditions affecting growth such as dwarfism and gigantism. Mutations in the GHRHR gene can disrupt normal growth hormone signaling leading to reduced or excessive growth. Gigantism involves increased growth hormone secretion often related to pituitary gland abnormalities. In contrast dwarfism may result from insufficient growth hormone action due to receptor defects. GHRHR's interaction with GHRH and its role in growth hormone regulation highlight its significance in these growth-related disorders.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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1 product image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GHRHR antibody (ab28692)
ab28692 staining Human GHRHR in human ovarian carcinoma samples by immunohistochemistry using paraffin embedded tissue.
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