AB28692

Anti-GHRHR antibody

Name: Anti-GHRHR antibody (ab28692) | Abcam
Brand: Abcam Limited
SKU: AB28692

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(28 Publications)

Rabbit Polyclonal GHRHR antibody. Suitable for IHC-P and reacts with Human samples. Cited in 28 publications. Immunogen corresponding to Synthetic Peptide within Human Growth hormone-releasing hormone receptor aa 400 to C-terminus conjugated to Keyhole Limpet Haemocyanin.

View Alternative Names

Growth hormone-releasing hormone receptor, GHRH receptor, Growth hormone-releasing factor receptor, GRF receptor, GRFR, GHRHR

1 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GHRHR antibody (AB28692)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GHRHR antibody (AB28692)

ab28692 staining Human GHRHR in human ovarian carcinoma samples by immunohistochemistry using paraffin embedded tissue.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human Growth hormone-releasing hormone receptor aa 400 to C-terminus conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

Q02643

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/1000", "IHCP-species-notes": "<p>Perform heat mediated antigen retrieval via the microwave method for 20 minutes in citric acid at pH 6.0.</p> Perform heat-mediated antigen retrieval via the microwave method before commencing with IHC staining protocol." } } }

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Properties and storage information

Form

Liquid

Purity

Whole antiserum

Storage buffer

Preservative: 0.05% Sodium azide Constituents: Whole serum

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

GHRHR also known as the growth hormone-releasing hormone receptor is an important protein that plays an important role mechanistically in the human body. This receptor is located on the cell membrane and binds to growth hormone-releasing hormone (GHRH). GHRHR is expressed predominantly in the pituitary gland. It has a molecular mass of approximately 44 kDa and its activation leads to the intracellular signaling cascades that promote growth hormone secretion.

Biological function summary

The interaction of GHRHR with GHRH is necessary for the regulation of growth hormone release. This receptor is not part of a larger complex; instead it functions individually as a receptor. GHRHR's role in stimulating growth hormone release makes it essential for normal growth metabolism and body composition. It influences processes like protein synthesis lipolysis and the maintenance of normal glucose levels.

Pathways

GHRHR operates within the growth hormone signaling pathway. This pathway involves the activation of GHRHR by GHRH which leads to the stimulation of adenylate cyclase increasing cyclic AMP levels resulting in growth hormone release. This pathway is interconnected with other signaling proteins like somatostatin which acts as an inhibitor of growth hormone secretion providing a balance in growth regulation.

GHRHR has been linked to conditions affecting growth such as dwarfism and gigantism. Mutations in the GHRHR gene can disrupt normal growth hormone signaling leading to reduced or excessive growth. Gigantism involves increased growth hormone secretion often related to pituitary gland abnormalities. In contrast dwarfism may result from insufficient growth hormone action due to receptor defects. GHRHR's interaction with GHRH and its role in growth hormone regulation highlight its significance in these growth-related disorders.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
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Target data

Receptor for GRF, coupled to G proteins which activate adenylyl cyclase. Stimulates somatotroph cell growth, growth hormone gene transcription and growth hormone secretion.

See full target information Growth hormone-releasing hormone receptor

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Publications (28)

Recent publications for all applications. Explore the full list and refine your search

Proceedings of the National Academy of Sciences of the United States of America 120:e2216814120 PubMed36603028

2023

Agonist of growth hormone-releasing hormone improves the disease features of spinal muscular atrophy mice.

Applications

Unspecified application

Species

Unspecified reactive species

Marina Boido,Iacopo Gesmundo,Anna Caretto,Francesca Pedrolli,Roberta Schellino,Sheila Leone,Renzhi Cai,Wei Sha,Ezio Ghigo,Andrew V Schally,Alessandro Vercelli,Riccarda Granata

Endocrines 3:813-820 PubMed36540765

2022

Growth Hormone-Releasing Hormone Antagonist JV-1-36 Suppresses Reactive Oxygen Species Generation in A549 Lung Cancer Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Khadeja-Tul Kubra,Mohammad S Akhter,Kaitlyn Apperley,Nektarios Barabutis

Journal of biochemical and molecular toxicology 35:e22879 PubMed34369038

2021

Suppression of reactive oxygen species in endothelial cells by an antagonist of growth hormone-releasing hormone.

Applications

Unspecified application

Species

Unspecified reactive species

Mohammad S Akhter,Nektarios Barabutis

Hormone and metabolic research = Hormon- und Stoff 52:336-339 PubMed32403147

2020

GHRH Antagonists Protect Against Hydrogen Peroxide-Induced Breakdown of Brain Microvascular Endothelium Integrity.

Applications

Unspecified application

Species

Unspecified reactive species

Nektarios Barabutis,Mohammad S Akhter,Mohammad A Uddin,Khadeja-Tul Kubra,Andrew V Schally

International journal of molecular sciences 21: PubMed32093298

2020

Thyrotropin-Releasing Hormone (TRH) and Somatostatin (SST), but not Growth Hormone-Releasing Hormone (GHRH) nor Ghrelin (GHRL), Regulate Expression and Release of Immune Growth Hormone (GH) from Chicken Bursal B-Lymphocyte Cultures.

Applications

Unspecified application

Species

Unspecified reactive species

Santiago Pech-Pool,Laura C Berumen,Carlos G Martínez-Moreno,Guadalupe García-Alcocer,Martha Carranza,Maricela Luna,Carlos Arámburo

Tissue barriers 7:1669989 PubMed31578921

2019

GHRH antagonists support lung endothelial barrier function.

Applications

Unspecified application

Species

Unspecified reactive species

Mohammad A Uddin,Mohammad S Akhter,Sitanshu S Singh,Khadeja-Tul Kubra,Andrew V Schally,Seetharama Jois,Nektarios Barabutis

Human mutation 40:2033-2043 PubMed31231873

2019

Contribution of functionally assessed GHRHR mutations to idiopathic isolated growth hormone deficiency in patients without GH1 mutations.

Applications

Unspecified application

Species

Unspecified reactive species

Enzo Cohen,Sabrina Belkacem,Soumeya Fedala,Nathalie Collot,Eliane Khallouf,Florence Dastot,Michel Polak,Philippe Duquesnoy,Frederic Brioude,Sophie Rose,Géraldine Viot,Aude Soleyan,Jean-Claude Carel,Marie-Laure Sobrier,Philippe Chanson,Frédérique Gatelais,Claudine Heinrichs,Noureddine Kaffel,Regis Coutant,Şenay Savaş Erdeve,Erdal Kurnaz,Zehra Aycan,Caroline Thalassinos,Stanislas Lyonnet,Zeynep Şıklar,Merih Berberoglu,Cécile Brachet,Serge Amselem,Marie Legendre

Experimental eye research 181:277-284 PubMed30831084

2019

Growth hormone-releasing hormone receptor mediates cytokine production in ciliary and iris epithelial cells during LPS-induced ocular inflammation.

Applications

Unspecified application

Species

Unspecified reactive species

Jia Lin Ren,Qiu Xiao Yu,Ding Ma,Wei Cheng Liang,Pui Ying Leung,Tsz Kin Ng,Wai Kit Chu,Andrew V Schally,Chi Pui Pang,Sun-On Chan

Investigative ophthalmology & visual science 59:5060-5066 PubMed30357400

2018

Induction of Apoptosis in Pterygium Cells by Antagonists of Growth Hormone-Releasing Hormone Receptors.

Applications

Unspecified application

Species

Unspecified reactive species

Yong Jie Qin,Wai Kit Chu,Li Huang,Clara Hoi Yen Ng,Tommy Chung Yan Chan,Di Cao,Cheng Yang,Liang Zhang,Shao Ping Huang,Juan Li,Hong Liang Lin,Wen Qian Li,Li Chen,Andrew V Schally,Sun On Chan,Hong Yang Zhang,Chi Pui Pang

British journal of haematology 181:476-485 PubMed29663325

2018

A new approach to the treatment of acute myeloid leukaemia targeting the receptor for growth hormone-releasing hormone.

Applications

Unspecified application

Species

Unspecified reactive species

Joaquin J Jimenez,Gina M DelCanto,Petra Popovics,Aymee Perez,Ailin Vila Granda,Irving Vidaurre,Ren-Zhi Cai,Ferenc G Rick,Ronan T Swords,Andrew V Schally

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-GHRHR antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GHRHR antibody (AB28692)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Alternative Products

Primary Antibodies

Primary Antibodies

Complementary Products

Secondary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity data

Properties and storage information

Form

Purity

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (28)

Product promise