Rabbit Polyclonal GHRHR antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human Growth hormone-releasing hormone receptor.
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Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.1% Sodium azide
Constituents: 99% PBS- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Human Growth hormone-releasing hormone receptor. The exact immunogen used to generate this antibody is proprietary information. Database link Q02643
Reactivity data
Select an application| IHC-P | |
|---|---|
| Human | Tested |
| Mouse | Predicted |
| Rat | Predicted |
| Common marmoset | Predicted |
| Gorilla | Predicted |
| Hamster | Predicted |
| Monkey | Predicted |
| Pig | Predicted |
| Rabbit | Predicted |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 16 µg/mL | Notes Perform heat-mediated antigen retrieval before commencing with IHC staining protocol. |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Rat, Rabbit, Hamster, Pig, Monkey, Gorilla, Common marmoset | Dilution info - | Notes - |
Associated Products
Select an associated product type
2 products for Alternative Product
Target data
Function
Receptor for GRF, coupled to G proteins which activate adenylyl cyclase. Stimulates somatotroph cell growth, growth hormone gene transcription and growth hormone secretion.
Alternative names
Growth hormone-releasing hormone receptor, GHRH receptor, Growth hormone-releasing factor receptor, GRF receptor, GRFR, GHRHR
Recommended products
Rabbit Polyclonal GHRHR antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human Growth hormone-releasing hormone receptor.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.1% Sodium azide
Constituents: 99% PBS- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Human Growth hormone-releasing hormone receptor. The exact immunogen used to generate this antibody is proprietary information. Database link Q02643
- Purification technique
- Affinity purification Immunogen
- Specificity
BLAST analysis of the peptide immunogen showed no homology with other Human proteins.
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
GHRHR also known as the growth hormone-releasing hormone receptor is an important protein that plays an important role mechanistically in the human body. This receptor is located on the cell membrane and binds to growth hormone-releasing hormone (GHRH). GHRHR is expressed predominantly in the pituitary gland. It has a molecular mass of approximately 44 kDa and its activation leads to the intracellular signaling cascades that promote growth hormone secretion.
- Biological function summary
The interaction of GHRHR with GHRH is necessary for the regulation of growth hormone release. This receptor is not part of a larger complex; instead it functions individually as a receptor. GHRHR's role in stimulating growth hormone release makes it essential for normal growth metabolism and body composition. It influences processes like protein synthesis lipolysis and the maintenance of normal glucose levels.
- Pathways
GHRHR operates within the growth hormone signaling pathway. This pathway involves the activation of GHRHR by GHRH which leads to the stimulation of adenylate cyclase increasing cyclic AMP levels resulting in growth hormone release. This pathway is interconnected with other signaling proteins like somatostatin which acts as an inhibitor of growth hormone secretion providing a balance in growth regulation.
- Associated diseases and disorders
GHRHR has been linked to conditions affecting growth such as dwarfism and gigantism. Mutations in the GHRHR gene can disrupt normal growth hormone signaling leading to reduced or excessive growth. Gigantism involves increased growth hormone secretion often related to pituitary gland abnormalities. In contrast dwarfism may result from insufficient growth hormone action due to receptor defects. GHRHR's interaction with GHRH and its role in growth hormone regulation highlight its significance in these growth-related disorders.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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1 product image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GHRHR antibody - C-terminal (ab150575)
Immunohistochemical analysis of formalin-fixed, paraffin embedded Human anterior pituitary tissue labeling GHRHR with ab150575 at 16ug/ml.
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