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AB28344

Anti-Giardia lamblia antibody

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(1 Publication)

Goat Polyclonal Giardia lamblia antibody. Suitable for ELISA, ICC/IF and reacts with Giardia lamblia samples. Cited in 1 publication. Immunogen corresponding to Cell preparation containing Giardia lamblia protein.

View Alternative Names

G lamblia, Giardia intestinalis

Key facts

Host species

Goat

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Giardia lamblia

Applications

ICC/IF, ELISA

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

Specificity

Ab28344 recognises Giardia lamblia intact cysts.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Giardia lamblia": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification notes
Ab28344 is >95% pure. Purification was by sodium sulfate precipitation and ion exchange chromatography.
Storage buffer
Preservative: 0.1% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Giardia lamblia often called Giardia is a flagellated protozoan parasite and its mechanical function is important in understanding giardiasis the disease it causes. Its trophozoite form which is around 10-20 μm long attaches to the intestinal epithelium of the host leading to infection. The organism uses its adhesive disc to interact with the host. The parasite is able to express various surface proteins to adapt to the host's immune system; among these variant-specific surface proteins (VSPs) play a significant role in its survival and virulence.
Biological function summary

Giardia lamblia causes diarrhea and malnutrition due to malabsorption in the intestines. The organism disrupts the normal epithelial barrier which results in impaired digestion and nutrient uptake. It is not part of a complex but does produce cysts that resist harsh environmental conditions outside the host. These cysts facilitate transmission and protect the parasite until it reaches a new host. The detected antigens in the stool play an important role in diagnosis such as using tests like antigardia and giardia ELISA.

Pathways

The interaction of Giardia lamblia with the intestinal cells involves several significant biological processes. It disrupts host signaling pathways associated with tight junctions such as the actin cytoskeleton pathway. Related proteins like myosin light chain kinase (MLCK) become activated leading to alteration of epithelial barrier functions. This affects the integrity of intestinal tight junctions causing permeability issues and contributing to diarrhea.

Giardia lamblia is closely connected with giardiasis characterized by symptoms like diarrhea weight loss and abdominal discomfort. The disruption of the intestinal epithelial barrier by Giardia relates to another protein zonulin which is associated with increased intestinal permeability. Although usually self-limiting giardiasis can have significant impacts especially in children and immunocompromised individuals triggering other gastrointestinal disorders if not properly addressed.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information Giardia lamblia
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Proteomics. Clinical applications 4:416-25 PubMed20535238

2010

Candidate biomarkers in exosome-like vesicles purified from rat and mouse urine samples.

Applications

Unspecified application

Species

Unspecified reactive species

Javier Conde-Vancells,Eva Rodriguez-Suarez,Esperanza Gonzalez,Agustin Berisa,David Gil,Nieves Embade,Mikel Valle,Zigmund Luka,Felix Elortza,Conrad Wagner,Shelly C Lu,Jose M Mato,M Falcon-Perez
View all publications
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Product promise

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