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AB236524

Anti-GilZ / TilZ antibody [OTI1F11]

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(1 Publication)

Mouse Monoclonal GilZ / TilZ antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human TSC22D3.

View Alternative Names

DSIPI, GILZ, TSC22D3, TSC22 domain family protein 3, DSIP-immunoreactive peptide, Delta sleep-inducing peptide immunoreactor, Glucocorticoid-induced leucine zipper protein, TSC-22-like protein, TSC-22-related protein, Protein DIP, hDIP, TSC-22R

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

OTI1F11

Isotype

IgG1

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human TSC22D3.

Q99576

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Alternative Products

Primary Antibodies

AB197987

Anti-GilZ / TilZ antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GilZ / TilZ antibody (AB197987)

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Complementary Products

Primary Antibodies

AB134175

Anti-Cyclin D1 antibody [EPR2241] - C-terminal

20ul selling size|BOND RX™ Validated|KO Validated|RabMAb|Recombinant|Lab Essentials

Western blot - Anti-Cyclin D1 antibody [EPR2241] - C-terminal (AB134175)

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Primary Antibodies

AB223410

Alexa Fluor® 488 Anti-IgA antibody [EPR5367-76]

RabMAb|Recombinant

Immunohistochemistry (Frozen sections) - Alexa Fluor® 488 Anti-IgA antibody [EPR5367-76] (AB223410)

  • 4
  • 1
Proteins & Peptides

AB134597

Recombinant Human GilZ / TilZ protein (His tag N-Terminus)

SDS-PAGE - Recombinant Human GilZ / TilZ protein (His tag N-Terminus) (AB134597)

  • 0
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Assay Kits

AB112136

Lysosomal Staining Kit - Green Fluorescence - Cytopainter

Fluorescence Microscopy - Lysosomal Staining Kit - Green Fluorescence - Cytopainter (AB112136)

  • 0
  • 0
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/2000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Orangutan": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification
Purification notes
Purified from cell culture supernatant.
Storage buffer
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

GilZ also known as glucocorticoid-induced leucine zipper is a protein with a mass of approximately 14 kDa. This protein acts mechanically as a transcriptional regulator and plays an important role in modulating immune cell functions. GilZ is widely expressed especially in lymphoid tissues and in cells involved in the immune response. It is also expressed in various other tissues including the brain and liver where it contributes to different cellular processes. This protein is linked to the suppression of certain inflammatory responses mediated by its interactions with key transcription factors.
Biological function summary

GilZ influences immune cell proliferation and differentiation impacting how the body responds to inflammation. It frequently forms complexes with other proteins to perform its functions. GilZ serves as a mediator of glucocorticoid actions which affects the expression of cytokines and other inflammatory mediators. Through its interactions with components of the immune system GilZ plays an important role in maintaining homeostasis under stress conditions such as during an inflammatory response or cell damage.

Pathways

The glucocorticoid pathway is central to the activities of GilZ. This pathway involves a complex network where GilZ interacts with proteins such as the NF-kB which is another transcription factor involved in the inflammatory response. GilZ affects this pathway by inhibiting the activity of NF-kB leading to decreased expression of pro-inflammatory cytokines. Additionally GilZ is involved in the T-cell receptor (TCR) signaling pathway where it modulates T-cell activation and survival affecting immune system regulation.

GilZ is relevant to conditions characterized by chronic inflammation such as rheumatoid arthritis and asthma. In these diseases the protein's ability to downregulate inflammation makes it a potential target for therapeutic intervention. GilZ influences the expression and activity of proteins like cytokines which are heavily involved in the inflammatory pathways of these diseases. Understanding the role of GilZ in these contexts could aid in designing more effective treatments for inflammatory conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11 (PubMed : 15031210). In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10 (PubMed : 12393603). In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation and thereby NFKB1 DNA-binding activities (PubMed : 11468175). In vitro, suppresses AP-1 transcription factor complex DNA-binding activities (By similarity).. Isoform 1. Inhibits myogenic differentiation and mediates anti-myogenic effects of glucocorticoids by binding and regulating MYOD1 and HDAC1 transcriptional activity resulting in reduced expression of MYOG.
See full target information TSC22D3
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Haematologica 105:136-147 PubMed31018977

2019

The vascular bone marrow niche influences outcome in chronic myeloid leukemia the E-selectin - SCL/TAL1 - CD44 axis.

Applications

Unspecified application

Species

Unspecified reactive species

Parimala Sonika Godavarthy,Rahul Kumar,Stefanie C Herkt,Raquel S Pereira,Nina Hayduk,Eva S Weissenberger,Djamel Aggoune,Yosif Manavski,Tina Lucas,Kuan-Ting Pan,Jenna M Voutsinas,Qian Wu,Martin C Müller,Susanne Saussele,Thomas Oellerich,Vivian G Oehler,Joern Lausen,Daniela S Krause
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

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