Anti-GIMAP6 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

GIMAP6 also known as GTPase IMAP family member 6 plays a significant role in cellular mechanisms. It is a small GTPase with a molecular mass of approximately 33 kDa. GIMAP6 is highly expressed in immune-related tissues particularly in lymphoid organs such as the spleen and lymph nodes. Unlike some proteins with widespread expression the presence of GIMAP6 seems more restricted to specific immune cells indicating its specialized functions in the immune system.

Biological function summary

The functions involving GTPase such as GIMAP6 regulate immune cell survival and homeostasis. It participates in critical cellular processes like apoptosis and autophagy often interacting with other members of the GIMAP family. GIMAP6 involvement suggests its integration in protein complexes that maintain cellular balance and response to stressors. Due to these activities GIMAP6 helps to modulate cell fate decisions in lymphocytes and perhaps other immune cells.

Pathways

Knowledge about GIMAP6 connects it to the regulation of autophagy and apoptosis pathways. It possibly interacts with molecules like Beclin-1 which plays a central role in the autophagy pathway. These interactions imply a connection to the PI3K/Akt signaling pathway where GIMAP proteins can influence survival signals and cellular responses. Therefore GIMAP6 has the potential to intersect with pathways involving other GTPase family proteins highlighting its influence within immune signaling networks.

Associated diseases and disorders

Research links GIMAP6 with autoimmune diseases and certain types of lymphoproliferative disorders. Variations in GIMAP6 expression or activity can contribute to immune dysregulation observed in these conditions. Furthermore GIMAP6 relationships with proteins like Bcl-2 known for roles in apoptosis regulation highlight its importance in diseases where cell survival and death mechanisms are disrupted. The understanding of GIMAP6 in these contexts might offer insights into novel therapeutic approaches for immune-related conditions.