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AB126067

Anti-GIMAP6 antibody

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(1 Publication)

Rabbit Polyclonal GIMAP6 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human GIMAP6 aa 1-250.

View Alternative Names

IAN2, IAN6, GIMAP6, GTPase IMAP family member 6, Immunity-associated nucleotide 2 protein, Immunity-associated nucleotide 6 protein, IAN-2, hIAN2, IAN-6, hIAN6

1 Images
Western blot - Anti-GIMAP6 antibody (AB126067)
  • WB

Unknown

Western blot - Anti-GIMAP6 antibody (AB126067)

12% SDS PAGE

All lanes:

Western blot - Anti-GIMAP6 antibody (ab126067) at 1/1000 dilution

All lanes:

MCF7 whole cell lysate at 30 µg

Predicted band size: 33 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human GIMAP6 aa 1-250. The exact immunogen used to generate this antibody is proprietary information.

Q6P9H5

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>" } } }

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

GIMAP6 also known as GTPase IMAP family member 6 plays a significant role in cellular mechanisms. It is a small GTPase with a molecular mass of approximately 33 kDa. GIMAP6 is highly expressed in immune-related tissues particularly in lymphoid organs such as the spleen and lymph nodes. Unlike some proteins with widespread expression the presence of GIMAP6 seems more restricted to specific immune cells indicating its specialized functions in the immune system.
Biological function summary

The functions involving GTPase such as GIMAP6 regulate immune cell survival and homeostasis. It participates in critical cellular processes like apoptosis and autophagy often interacting with other members of the GIMAP family. GIMAP6 involvement suggests its integration in protein complexes that maintain cellular balance and response to stressors. Due to these activities GIMAP6 helps to modulate cell fate decisions in lymphocytes and perhaps other immune cells.

Pathways

Knowledge about GIMAP6 connects it to the regulation of autophagy and apoptosis pathways. It possibly interacts with molecules like Beclin-1 which plays a central role in the autophagy pathway. These interactions imply a connection to the PI3K/Akt signaling pathway where GIMAP proteins can influence survival signals and cellular responses. Therefore GIMAP6 has the potential to intersect with pathways involving other GTPase family proteins highlighting its influence within immune signaling networks.

Research links GIMAP6 with autoimmune diseases and certain types of lymphoproliferative disorders. Variations in GIMAP6 expression or activity can contribute to immune dysregulation observed in these conditions. Furthermore GIMAP6 relationships with proteins like Bcl-2 known for roles in apoptosis regulation highlight its importance in diseases where cell survival and death mechanisms are disrupted. The understanding of GIMAP6 in these contexts might offer insights into novel therapeutic approaches for immune-related conditions.

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Molecular medicine reports 14:4119-4123 PubMed27667392

2016

Dysregulation of GTPase IMAP family members in hepatocellular cancer.

Applications

IHC-P

Species

Human

Zhen Huang,Wei Zhang,Chunhai Gao,Baoju Ji,Xiuwen Chi,Wei Zheng,Hai Lan Wang
View all publications

Product promise

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