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AB136266

Anti-GIPR antibody

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(3 Publications)

Rabbit Polyclonal GIPR antibody. Suitable for WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human GIPR.

View Alternative Names

Gastric inhibitory polypeptide receptor, GIP-R, Glucose-dependent insulinotropic polypeptide receptor, GIPR

1 Images
Western blot - Anti-GIPR antibody (AB136266)
  • WB

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Western blot - Anti-GIPR antibody (AB136266)

All lanes:

Western blot - Anti-GIPR antibody (ab136266) at 1/500 dilution

All lanes:

HT29 cell lysate at 30 µg

Predicted band size: 53 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human GIPR. The exact immunogen used to generate this antibody is proprietary information.

P48546

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Alternative Products

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GIPR antibody - N-terminal (AB188591)

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Human IgG antibody [EPR4421] (AB109489)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
ab136266 was affinity-purified from rabbit antiserum by immunogenic peptide affinity-chromatography.
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The gastric inhibitory polypeptide receptor (GIPR) sometimes called glucose-dependent insulinotropic polypeptide receptor is a member of the class B1 family of G-protein-coupled receptors. GIPR weighs approximately 52 kDa and is widely expressed in pancreatic beta-cells adipose tissue and the central nervous system. It binds to its ligand the gastric inhibitory polypeptide (GIP) which is critical for its functional activities.
Biological function summary

Without directly naming GIPR it plays significant roles in glucose homeostasis and lipid metabolism. GIPR is not part of a larger protein complex but binds to GIP to initiate signaling pathways that stimulate insulin secretion. This receptor-ligand interaction is essential in regulating postprandial (after meals) insulin release influencing glucose and fat utilization and storage in the body.

Pathways

GIPR participates critically in the incretin signaling pathway. It associates with other incretin receptors like the glucagon-like peptide-1 receptor (GLP-1R) which collectively enhance glucose-induced insulin release. Within the glucose-regulatory network GIPR's interaction with these pathways highlights its role in managing energy balance and promoting beta-cell function.

With reference to obesity and type 2 diabetes GIPR has a substantial impact. Disruptions in GIPR signaling have been linked to impaired insulin secretion and glucose intolerance contributing to these metabolic disorders. Researchers also explore potential connections between GIPR and other proteins like insulin receptor substrate proteins in these conditions as these interactions are critical in understanding the receptor's role in metabolic dysregulation.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

This is a receptor for GIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
See full target information GIPR
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Cancers 16: PubMed38730608

2024

Gastric Inhibitory Polypeptide Receptor (GIPR) Overexpression Reduces the Tumorigenic Potential of Retinoblastoma Cells.

Applications

Unspecified application

Species

Unspecified reactive species

André Haase,Emily Alefeld,Fatma Yalinci,Dario Van Meenen,Maike Anna Busch,Nicole Dünker

Journal of Cancer 15:632-644 PubMed38213736

2024

Exploring Prognostic Immune Microenvironment-Related Genes in Head and Neck Squamous Cell Carcinoma from the TCGA Database.

Applications

Unspecified application

Species

Unspecified reactive species

Shuangjiang Li,Yiyu Zeng,Liming He,Xiaoyan Xie

Cell reports. Medicine 2:100263 PubMed34095876

2021

GIPR antagonist antibodies conjugated to GLP-1 peptide are bispecific molecules that decrease weight in obese mice and monkeys.

Applications

Unspecified application

Species

Unspecified reactive species

Shu-Chen Lu,Michelle Chen,Larissa Atangan,Elizabeth A Killion,Renee Komorowski,Yuan Cheng,Chawita Netirojjanakul,James R Falsey,Marina Stolina,Denise Dwyer,Clarence Hale,Shanaka Stanislaus,Todd Hager,Veena A Thomas,John M Harrold,David J Lloyd,Murielle M Véniant
View all publications
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Product promise

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