JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB224083

Anti-GLG1 antibody

Be the first to review this product! Submit a review

|

(1 Publication)

Rabbit Polyclonal GLG1 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human GLG1 aa 950 to C-terminus.

View Alternative Names

CFR1, ESL1, MG160, GLG1, Golgi apparatus protein 1, CFR-1, Cysteine-rich fibroblast growth factor receptor, E-selectin ligand 1, Golgi sialoglycoprotein MG-160, ESL-1

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GLG1 antibody (AB224083)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GLG1 antibody (AB224083)

Paraffin embedded human placenta tissue stained for GLG1 with ab224083 (1/200 dilution) in immunohistochemical analysis.

Immunocytochemistry/ Immunofluorescence - Anti-GLG1 antibody (AB224083)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-GLG1 antibody (AB224083)

PFA-fixed, Triton X-100 permeabilized U-251 MG (human brain glioma cell line) cells stained for GLG1 (green) using ab224083 (4 μg/ml) in ICC/IF.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human GLG1 aa 950 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q92896

style
left-column

Alternative Products

Primary Antibodies

AB262704

Anti-GLG1 antibody

Western blot - Anti-GLG1 antibody (AB262704)

  • 0
  • 0

Complementary Products

Primary Antibodies

AB19072

Anti-58K Golgi protein antibody - Golgi Marker

Flow Cytometry - Anti-58K Golgi protein antibody - Golgi Marker (AB19072)

  • 0
  • 0
Primary Antibodies

AB227836

Anti-PSGL-1 antibody [EPR22504-36]

BOND RX™ Validated|RabMAb|Recombinant

Flow Cytometry - Anti-PSGL-1 antibody [EPR22504-36] (AB227836)

  • 0
  • 0
Primary Antibodies

AB52649

Anti-GM130 antibody [EP892Y] - cis-Golgi Marker

RabMAb|Recombinant|Lab Essentials|20ul selling size

Immunoprecipitation - Anti-GM130 antibody [EP892Y] - cis-Golgi Marker (AB52649)

  • 5
  • 39
Primary Antibodies

AB252666

Anti-GAD65 antibody [EPR20431-115] - BSA and Azide free (Detector)

RabMAb|Recombinant

Sandwich ELISA - Anti-GAD65 antibody [EPR20431-115] - BSA and Azide free (Detector) (AB252666)

  • 0
  • 0
style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/200 - 1/500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100.</p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Chicken": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Chinese hamster": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

GLG1 also known as Golgi apparatus protein 1 or p58 is a transmembrane protein with a molecular weight of about 150 kDa. It expresses abundantly in the Golgi apparatus where it functions in the sorting and transport of proteins. GLG1 interacts with glycoproteins containing high mannose aiding their retention until they mature and are fully processed. Its expression is observed not only in most cell types but also prominently in tissues with high secretion activity.
Biological function summary

The function of GLG1 involves participating in the formation and maintenance of the Golgi structure. It is part of the larger protein complex responsible for trafficking glycoproteins within the cell. GLG1 collaborates with other proteins within the Golgi to ensure proper processing and modification of proteins by glycosylation. This involvement makes GLG1 critical in regulating protein quality control and maintaining organelle integrity within cells.

Pathways

The function of GLG1 integrates into the secretory and endoplasmic reticulum-to-Golgi transport pathways. The target aids in modulating protein folding and sorting processes that are essential for cellular homeostasis. It has functional interactions with other Golgi-related proteins like GM130 and proteins involved in transport such as COPI coated vesicle proteins. It plays a supporting role in vesicular trafficking ensuring that proteins reach their correct cellular destinations.

Dysfunctions or alterations in GLG1 expression are linked to congenital disorders of glycosylation. These disorders occur due to impaired glycoprotein processing and transport. GLG1's involvement in these pathways further implicates it in diseases where protein trafficking and glycosylation are disrupted. Moreover it is linked with diseases involving disrupted Golgi function which could be associated with proteins like GOLPH3 that might also have roles in Golgi-related pathologies.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

Binds fibroblast growth factor and E-selectin (cell-adhesion lectin on endothelial cells mediating the binding of neutrophils).
See full target information GLG1
style
left-column

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

International journal of molecular sciences 23: PubMed35008858

2021

New Proteins Contributing to Immune Cell Infiltration and Pannus Formation of Synovial Membrane from Arthritis Diseases.

Applications

Unspecified application

Species

Unspecified reactive species

Dominique de Seny,Dominique Baiwir,Elettra Bianchi,Gaël Cobraiville,Céline Deroyer,Christophe Poulet,Olivier Malaise,Geneviève Paulissen,Marie-Joëlle Kaiser,Jean-Philippe Hauzeur,Gabriel Mazzucchelli,Philippe Delvenne,Michel Malaise
View all publications
style
left-column
style
left-column
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com