Anti-GLIS3 antibody

Supplementary info

Activity summary

GLIS3 also known as GLIS family zinc finger 3 is a transcription factor with important roles in gene expression regulation. GLIS3 has a molecular mass of approximately 93 kDa. This protein is expressed in multiple tissues including the pancreas thyroid and kidney. GLIS3 contains five Kruppel-like zinc finger domains that facilitate its ability to bind to DNA and mediate transcriptional regulation.

Biological function summary

GLIS3 influences various cellular processes most notably those related to pancreatic function and insulin production. It acts as part of a transcriptional complex that modulates the expression of genes critical for beta-cell development and function. This action establishes its important role in maintaining glucose homeostasis. By binding to specific DNA sites GLIS3 regulates genes involved in producing insulin and maintaining proper endocrine pancreas function.

Pathways

GLIS3 plays integral roles in the insulin signaling and glucose metabolism pathways. It interacts with proteins such as PDX1 and NEUROD1 both of which are essential for beta-cell development and insulin gene expression. The involvement of GLIS3 in these pathways highlights its importance in glucose regulation and metabolic balance within the body.

Associated diseases and disorders

GLIS3 has significant links with neonatal diabetes and hypothyroidism. Mutations in the GLIS3 gene can lead to congenital hypothyroidism by disrupting thyroid hormone production and regulation. Moreover GLIS3's influence on insulin production and pancreatic beta-cell function implicates it in neonatal diabetes development. Its interaction with other proteins like NEUROD1 and PDX1 further establishes its association with these metabolic and endocrine disorders.