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Rabbit Recombinant Monoclonal GLP2R antibody. Suitable for WB and reacts with Human samples.

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Images

Western blot - Anti-GLP2R antibody [EPR12812] (AB181030), expandable thumbnail

Key facts

Isotype
IgG
Host species
Rabbit
Storage buffer

Preservative: 0.01% Sodium azide
Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA

Form
Liquid
Clonality
Monoclonal

Immunogen

  • The exact immunogen used to generate this antibody is proprietary information.

Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
Flow CytWB
Human
Not recommended
Tested

Not recommended
Not recommended

Species
Human
Dilution info
-
Notes

-

Tested
Tested

Species
Human
Dilution info
1/1000
Notes

-

Associated Products

Select an associated product type

2 products for Alternative Product

Target data

Function

This is a receptor for glucagon-like peptide 2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

Alternative names

Glucagon-like peptide 2 receptor, GLP-2 receptor, GLP-2-R, GLP-2R, GLP2R

Recommended products

Rabbit Recombinant Monoclonal GLP2R antibody. Suitable for WB and reacts with Human samples.

Key facts

Isotype
IgG
Form
Liquid
Clonality
Monoclonal
Immunogen
  • The exact immunogen used to generate this antibody is proprietary information.
Clone number
EPR12812
Purification technique
Affinity purification Protein A
Concentration
Loading...

Storage

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle

Notes

Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.
Activity summary

GLP2R also known as Glucagon-Like Peptide 2 Receptor is a G-protein coupled receptor with a mass of approximately 63 kDa. It is expressed in various tissues most notably in the small intestine colon and central nervous system. This receptor binds to glucagon-like peptide 2 (GLP-2) and plays a role in mediating intestinal growth and function. As a member of the B1 receptor family GLP2R uses adenylate cyclase to convert ATP to cAMP leading to downstream cellular effects.

Biological function summary

GLP2R modulates several functions related to gut health and integrity. It does not function as part of a larger protein complex but has significant roles when activated by its ligand GLP-2. The receptor supports intestinal epithelial growth enhances nutrient absorption and mitigates inflammatory responses in the gut lining. Additionally GLP2R activity promotes maintenance of mucosal integrity and supports a barrier against pathogens.

Pathways

GLP2R is important in the regulation of the intestinal growth pathway and nutrient absorption. It interacts with related proteins like glucagon and GLP-1 receptors which are part of the glucagon receptor family. These pathways involve processes that control gut motility secretion and cell proliferation. By mediating these signaling pathways GLP2R ensures effective gut homeostasis.

Associated diseases and disorders

GLP2R has associations with conditions such as short bowel syndrome and inflammatory bowel disease. In short bowel syndrome GLP2R activity supports gut adaptation thereby improving nutrient absorption. In inflammatory bowel disease its role in reducing intestinal inflammation and repairing the mucosa links it to potential therapeutic targets. Connections through the disease pathways include interactions with proteins like inflammatory cytokines and growth factors which influence immune response and epithelial repair mechanisms.

Product promise

We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.

In the unlikely event of one of our products not working as expected, you are covered by our product promise.

Full details and terms and conditions can be found here:
Terms & Conditions.

1 product image

  • Western blot - Anti-GLP2R antibody [EPR12812] (ab181030), expandable thumbnail

    Western blot - Anti-GLP2R antibody [EPR12812] (ab181030)

    All lanes: Western blot - Anti-GLP2R antibody [EPR12812] (ab181030) at 1/1000 dilution

    Lane 1: HEK-293 (Human embryonic kidney epithelial cell) whole cell lysate

    Lane 2: A549 (Human lung carcinoma epithelial cell) whole cell lysate

    Secondary

    All lanes: Western blot - Goat Anti-Rabbit IgG H&L (HRP) (Goat Anti-Rabbit IgG H&L (HRP) ab97051) at 1/20000 dilution

    Predicted band size: 63 kDa

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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