Rabbit Polyclonal GLP2R antibody. N-terminal. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human Glucagon-like peptide 2 receptor.
Images
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.1% Sodium azide
Constituents: 99% PBS- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Human Glucagon-like peptide 2 receptor. The exact immunogen used to generate this antibody is proprietary information. Database link O95838
Reactivity data
Select an application| IHC-P | |
|---|---|
| Human | Tested |
| Gorilla | Predicted |
| Monkey | Predicted |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 5.00000-10.00000 µg/mL | Notes Perform heat-mediated antigen retrieval before commencing with IHC staining protocol. |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Monkey, Gorilla | Dilution info - | Notes - |
Associated Products
Select an associated product type
2 products for Alternative Product
Target data
Function
This is a receptor for glucagon-like peptide 2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
Alternative names
Glucagon-like peptide 2 receptor, GLP-2 receptor, GLP-2-R, GLP-2R, GLP2R
Recommended products
Rabbit Polyclonal GLP2R antibody. N-terminal. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human Glucagon-like peptide 2 receptor.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.1% Sodium azide
Constituents: 99% PBS- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Human Glucagon-like peptide 2 receptor. The exact immunogen used to generate this antibody is proprietary information. Database link O95838
- Purification technique
- Affinity purification Immunogen
- Specificity
BLAST analysis of the peptide immunogen showed no homology with other Human proteins.
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
GLP2R also known as Glucagon-Like Peptide 2 Receptor is a G-protein coupled receptor with a mass of approximately 63 kDa. It is expressed in various tissues most notably in the small intestine colon and central nervous system. This receptor binds to glucagon-like peptide 2 (GLP-2) and plays a role in mediating intestinal growth and function. As a member of the B1 receptor family GLP2R uses adenylate cyclase to convert ATP to cAMP leading to downstream cellular effects.
- Biological function summary
GLP2R modulates several functions related to gut health and integrity. It does not function as part of a larger protein complex but has significant roles when activated by its ligand GLP-2. The receptor supports intestinal epithelial growth enhances nutrient absorption and mitigates inflammatory responses in the gut lining. Additionally GLP2R activity promotes maintenance of mucosal integrity and supports a barrier against pathogens.
- Pathways
GLP2R is important in the regulation of the intestinal growth pathway and nutrient absorption. It interacts with related proteins like glucagon and GLP-1 receptors which are part of the glucagon receptor family. These pathways involve processes that control gut motility secretion and cell proliferation. By mediating these signaling pathways GLP2R ensures effective gut homeostasis.
- Associated diseases and disorders
GLP2R has associations with conditions such as short bowel syndrome and inflammatory bowel disease. In short bowel syndrome GLP2R activity supports gut adaptation thereby improving nutrient absorption. In inflammatory bowel disease its role in reducing intestinal inflammation and repairing the mucosa links it to potential therapeutic targets. Connections through the disease pathways include interactions with proteins like inflammatory cytokines and growth factors which influence immune response and epithelial repair mechanisms.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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1 product image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GLP2R antibody - N-terminal (ab188595)
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human small intestine tissue, labeling GLP2R with ab188595 at 10 μg/ml.
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