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AB188743

Anti-Glucagon Receptor antibody

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(1 Publication)

Rabbit Polyclonal Glucagon Receptor antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human Glucagon receptor.

View Alternative Names

Glucagon receptor, GL-R, GCGR

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Glucagon Receptor antibody (AB188743)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Glucagon Receptor antibody (AB188743)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human liver tissue labeling Glucagon Receptor using ab188743 at 13 μg/ml.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human Glucagon receptor. The exact immunogen used to generate this antibody is proprietary information.

P47871

Specificity

BLAST analysis of the peptide immunogen showed no homology with other Human proteins.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "13 µg/mL", "IHCP-species-notes": "<p></p>" }, "Gorilla": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Horse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Monkey": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Opossum": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.1% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The glucagon receptor also known as GCGR is a protein located on cell membranes and is about 62 kDa in mass. This receptor belongs to the G protein-coupled receptor (GPCR) family which plays a role in transmitting signals from glucagon—a hormone involved in glucose metabolism. GCGR is expressed mainly in liver kidney and pancreatic cells as well as some regions of the brain. Scientists often use recombinant glucagon proteins to study receptor behaviors and interactions due to their specific binding properties.
Biological function summary

Glucagon receptor activation primarily mediates glucose homeostasis by stimulating hepatic glucose production. It facilitates glycogenolysis and gluconeogenesis processes that increase blood glucose levels especially when glucose availability is low. The receptor does not operate in a complex but interacts closely with secondary messengers like cAMP (cyclic adenosine monophosphate) to trigger downstream signaling cascades. This action allows cells to respond quickly to changing hormonal signals in the bloodstream.

Pathways

Glucagon receptor is an important component of the glucagon signaling pathway and plays a part in the insulin resistance pathway. Upon activation by glucagon the receptor stimulates adenylate cyclase increasing cAMP production which activates protein kinase A (PKA). This process is closely linked with the insulin receptor pathway where both influence glucose and lipid metabolism balancing the metabolic responses within the liver and other tissues.

Glucagon receptor involvement is significant in diabetes and metabolic syndrome. Dysfunctional GCGR activity can contribute to hyperglycemia in type 2 diabetes by failing to regulate glucose production properly. Additionally it links to lipid metabolism disorders affecting triglyceride levels. Researchers focus on the receptor's relationship with insulin and other hormones to develop therapeutic strategies targeting glucagon and its receptor to manage these conditions effectively. Anti-glucagon drugs are under investigation to better control glucose levels in diabetic patients.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis. Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis. Plays an important role in mediating the responses to fasting. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Promotes activation of adenylate cyclase. Besides, plays a role in signaling via a phosphatidylinositol-calcium second messenger system.
See full target information Glucagon receptor
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Scientific reports 6:35205 PubMed27748416

2016

MicroRNA-127 targeting of mitoNEET inhibits neurite outgrowth, induces cell apoptosis and contributes to physiological dysfunction after spinal cord transection.

Applications

Unspecified application

Species

Unspecified reactive species

Qin-Qin He,Liu-Lin Xiong,Fei Liu,Xiang He,Guo-Ying Feng,Fei-Fei Shang,Qing-Jie Xia,You-Cui Wang,De-Lu Qiu,Chao-Zhi Luo,Jia Liu,Ting-Hua Wang
View all publications
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Product promise

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