Anti-Glucose Transporter GLUT1 antibody [GLUT1/2475]
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(2 Publications)
Mouse Monoclonal Glucose Transporter GLUT1 antibody. Suitable for IHC-P, PepArr and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human SLC2A1 aa 200-350.
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GLUT1, SLC2A1, HepG2 glucose transporter, GLUT-1
- IHC-P
Supplier Data
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Glucose Transporter GLUT1 antibody [GLUT1/2475] (AB238050)
Formalin-fixed, paraffin-embedded human tongue tissue stained for Glucose Transporter GLUT1 using ab238050 at 1 μg/ml in immunohistochemical analysis.
- IHC-P
Supplier Data
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Glucose Transporter GLUT1 antibody [GLUT1/2475] (AB238050)
Formalin-fixed, paraffin-embedded human bladder carcinoma tissue stained for Glucose Transporter GLUT1 using ab238050 at 1 μg/ml in immunohistochemical analysis.
- PepArr
Supplier Data
Peptide Array - Anti-Glucose Transporter GLUT1 antibody [GLUT1/2475] (AB238050)
Analysis of Protein Array containing more than 19,000 full-length human proteins using ab238050.
Z- and S- Score : The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.
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Supplementary information
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Biological function summary
This glucose transporter plays a significant role in maintaining glucose homeostasis in the human body. GLUT1 functions independently and not as part of a complex. It ensures that glucose is available to cells with high metabolic demands including the brain and red blood cells where it remains important for survival and function. Its expression level can be influenced by various factors including hypoxia and insulin.
Pathways
GLUT1 is involved in the glycolysis and hypoxia-related pathways. It supports the glycolytic pathway by ensuring a sufficient supply of glucose to the cells which is then metabolized to produce ATP. Additionally during hypoxic conditions GLUT1 expression can increase aligning with proteins like HIF-1α which helps cells adapt by modifying their metabolism. This coordinated regulation permits cells to adjust their energy systems according to the oxygen availability.
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Publications (2)
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Frontiers in molecular biosciences 8:806650 PubMed35096971
2022
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Unspecified reactive species
Cancer management and research 13:1099-1111 PubMed33574707
2021
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Unspecified application
Species
Unspecified reactive species
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