AB111117

Anti-Glucose Transporter GLUT2 antibody

Name: Anti-Glucose Transporter GLUT2 antibody (ab111117) | Abcam
Brand: Abcam Limited
SKU: AB111117
Price: 605 USD
Availability: InStock
Rating: 4 (4 reviews)

(4 Reviews)

(9 Publications)

Goat Polyclonal Glucose Transporter GLUT2 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 9 publications. Immunogen corresponding to Synthetic Peptide within Human SLC2A2 aa 250-300 conjugated to Keyhole Limpet Haemocyanin.

View Alternative Names

GLUT2, SLC2A2, GLUT-2

1 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Glucose Transporter GLUT2 antibody (AB111117)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Glucose Transporter GLUT2 antibody (AB111117)

ab111117, at 2.5µg/ml, staining Glucose Transporter GLUT2 in formalin-fixed, paraffin-embedded Human Liver tissue by Immunohistochemistry.

Key facts

Host species

Goat

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human SLC2A2 aa 250-300 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

P11168

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "2.5 µg/mL", "IHCP-species-notes": "<p></p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.3 Preservative: 0.02% Sodium azide Constituents: Tris buffered saline, 0.5% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The glucose transporter GLUT2 also referred to as GLUT 2 GLUT-2 or GLUT2 transporter plays an important role in the movement of glucose across cell membranes. Mechanically it acts as a facilitative transporter allowing glucose and other monosaccharides to enter and exit cells. GLUT2 has a molecular weight of about 55 kDa. High expression of GLUT2 occurs in the liver pancreas kidney and intestines where it facilitates bidirectional glucose transport to maintain glucose balance.

Biological function summary

The role of this transporter is important for glucose sensing and regulation. It is not part of any known complex but operates efficiently as a single unit within its membrane environment. In the pancreas GLUT2 detects blood glucose levels and initiates insulin release from beta cells. In the liver it enables glucose uptake during periods of high blood glucose and facilitates glucose production when blood glucose levels drop. By performing these functions GLUT2 helps maintain glucose homeostasis in the body.

Pathways

GLUT2 is an essential component of glucose homeostasis and nutrient sensing pathways. It links to the insulin signaling pathway by facilitating insulin secretion in response to increased blood glucose. Furthermore GLUT2 associates with kinases such as AMPK which modulate cellular energy balance. The synergistic activity between GLUT2 and insulin signaling pathways highlights its central role in metabolic processes.

Altered GLUT2 function has significant implications. Mutations or deficiencies in GLUT2 can lead to conditions like Fanconi-Bickel syndrome a rare glycogen storage disorder. This transporter has been connected to diabetes as well due to its involvement in insulin secretion regulation. In both these instances GLUT2 interacts with other proteins such as glucokinase in the pancreas and liver highlighting its importance in disease pathology.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Facilitative hexose transporter that mediates the transport of glucose, fructose and galactose (PubMed : 16186102, PubMed : 23396969, PubMed : 28083649, PubMed : 8027028, PubMed : 8457197). Likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of the beta cell (PubMed : 8027028). May also participate with the Na(+)/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney (PubMed : 3399500). Also able to mediate the transport of dehydroascorbate (PubMed : 23396969).

See full target information SLC2A2

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Publications (9)

Recent publications for all applications. Explore the full list and refine your search

Molecular metabolism 54:101330 PubMed34500108

2021

Vertical sleeve gastrectomy triggers fast β-cell recovery upon overt diabetes.

Applications

Unspecified application

Species

Unspecified reactive species

Lena Oppenländer,Subarna Palit,Kerstin Stemmer,Tobias Greisle,Michael Sterr,Ciro Salinno,Aimée Bastidas-Ponce,Annette Feuchtinger,Anika Böttcher, Ansarullah,Fabian J Theis,Heiko Lickert

Scientific reports 10:10727 PubMed32612127

2020

Feeding and food availability modulate brain-derived neurotrophic factor, an orexigen with metabolic roles in zebrafish.

Applications

Unspecified application

Species

Unspecified reactive species

Ayelén Melisa Blanco,Juan Ignacio Bertucci,Azadeh Hatef,Suraj Unniappan

Scientific reports 10:6993 PubMed32332781

2020

FGF21 Mimics a Fasting-Induced Metabolic State and Increases Appetite in Zebrafish.

Applications

Unspecified application

Species

Unspecified reactive species

Ayelén Melisa Blanco,Juan Ignacio Bertucci,Suraj Unniappan

Journal of cellular physiology 235:6875-6886 PubMed31989646

2020

Goldfish adipocytes are pancreatic beta cell-like, glucose-responsive insulin-producing cells.

Applications

Unspecified application

Species

Unspecified reactive species

Ayelén Melisa Blanco,Juan Ignacio Bertucci,Suraj Unniappan

Medical oncology (Northwood, London, England) 36:76 PubMed31342270

2019

Programmed death-1 receptor (PD-1) and PD-ligand-1 (PD-L1) expression in non-small cell lung cancer and the immune-suppressive effect of anaerobic glycolysis.

Applications

Unspecified application

Species

Unspecified reactive species

Alexandra Giatromanolaki,Ioannis M Koukourakis,Konstantina Balaska,Achilleas G Mitrakas,Adrian L Harris,Michael I Koukourakis

The Journal of physiology 597:431-447 PubMed30412665

2018

Exendin-4 overcomes cytokine-induced decreases in gap junction coupling via protein kinase A and Epac2 in mouse and human islets.

Applications

Unspecified application

Species

Unspecified reactive species

Nikki L Farnsworth,Rachelle Walter,Robert A Piscopio,Wolfgang E Schleicher,Richard K P Benninger

World journal of gastroenterology 24:775-793 PubMed29467549

2018

Glucose transporter expression in the human colon.

Applications

Unspecified application

Species

Unspecified reactive species

Flavia Merigo,Alessandro Brandolese,Sonia Facchin,Silvia Missaggia,Paolo Bernardi,Federico Boschi,Renata D'Incà,Edoardo Vincenzo Savarino,Andrea Sbarbati,Giacomo Carlo Sturniolo

Scientific reports 7:45024 PubMed28338019

2017

Ghrelin Facilitates GLUT2-, SGLT1- and SGLT2-mediated Intestinal Glucose Transport in Goldfish (Carassius auratus).

Applications

Unspecified application

Species

Unspecified reactive species

Ayelén Melisa Blanco,Juan Ignacio Bertucci,Naresh Ramesh,María Jesús Delgado,Ana Isabel Valenciano,Suraj Unniappan

Journal of diabetes research 2015:450128 PubMed25699277

2015

Diabetes-resistant NOR mice are more severely affected by streptozotocin compared to the diabetes-prone NOD mice: correlations with liver and kidney GLUT2 expressions.

Applications

Species

Unspecified reactive species

S Kahraman,C Aydin,G O Elpek,E Dirice,A D Sanlioglu

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Glucose Transporter GLUT2 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Glucose Transporter GLUT2 antibody (AB111117)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

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Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (9)

Product promise