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AB234756

Anti-Glucose Transporter GLUT3 antibody

0

(1 Review)

|

(2 Publications)

Rabbit Polyclonal Glucose Transporter GLUT3 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human SLC2A3 aa 200-300.

View Alternative Names

GLUT3, SLC2A3, GLUT-3

2 Images
Immunocytochemistry/ Immunofluorescence - Anti-Glucose Transporter GLUT3 antibody (AB234756)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-Glucose Transporter GLUT3 antibody (AB234756)

HepG2 (human liver hepatocellular carcinoma cell line) cells labeling Glucose Transporter GLUT3 (green) using ab234756 at 1/100 dilution in ICC/IF. Secondary antibody was Alexa Fluor® 488-conjugated goat anti-rabbit IgG (H+L).

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Glucose Transporter GLUT3 antibody (AB234756)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Glucose Transporter GLUT3 antibody (AB234756)

Paraffin-embedded human spleen tissue stained for Glucose Transporter GLUT3 using ab234756 at 1/100 dilution in immunohistochemical analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human SLC2A3 aa 200-300. The exact immunogen used to generate this antibody is proprietary information.

P11169

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/50 - 1/200", "ICCIF-species-notes": "<p></p>" } } }

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
>95%.
Storage buffer
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Glucose Transporter GLUT3 also known as GLUT-3 or SLC2A3 serves as an important protein in glucose transport across cell membranes. It is part of the facilitative glucose transporter family and exhibits a molecular weight of approximately 54 kDa. This transporter shows high affinity for glucose making it particularly important in cells with high demands for glucose. You mainly find GLUT3 expressed in brain neurons placenta and sperm where it ensures sufficient glucose uptake to sustain energy-intensive activities.
Biological function summary

The transporter protein mediates the rapid uptake of glucose into cells especially under low glucose concentrations supporting high cellular metabolic rates. It does not function alone but collaborates in transporting glucose to meet cellular needs efficiently. Although GLUT3 operates as a specific transporter it is involved in a larger network that ensures glucose availability for vital cellular processes ensuring that cells like neurons maintain function even under varying glucose availability.

Pathways

The transporter plays an integral role in the glycolysis and cellular respiration pathways. It acts in concert with other glucose transporters such as GLUT1 and GLUT4 which also facilitate glucose uptake into various cells allowing efficient energy production. The proper function of glycolysis heavily depends on the effective operation of glucose transporters where GLUT3's high affinity for glucose supports metabolic activities specifically in neural cells which relies on glucose as a primary energy source.

Several studies link GLUT3 to conditions like Alzheimer's disease and Type 2 diabetes. In Alzheimer's impaired glucose metabolism in the brain partly due to dysfunctional GLUT3 contributes to neurodegenerative processes. Similarly altered expression of GLUT3 affects glucose homeostasis playing a part in Type 2 diabetes pathophysiology alongside proteins like insulin receptors and other glucose transporters. These associations underline the significance of maintaining GLUT3 function for cellular glucose management and metabolic health.

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Target data

Facilitative glucose transporter (PubMed : 26176916, PubMed : 32860739, PubMed : 9477959). Can also mediate the uptake of various other monosaccharides across the cell membrane (PubMed : 26176916, PubMed : 9477959). Mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and probably also dehydroascorbate (PubMed : 26176916, PubMed : 9477959). Does not mediate fructose transport (PubMed : 26176916, PubMed : 9477959). Required for mesendoderm differentiation (By similarity).
See full target information SLC2A3

Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Inflammation 47:1820-1836 PubMed38565760

2024

Mast Cells are Dependent on Glucose Transporter 1 (GLUT1) and GLUT3 for IgE-mediated Activation.

Applications

Unspecified application

Species

Unspecified reactive species

Mirjana Grujic,Md Abdul Alim,Lars Hellman,Magnus Peterson,Gunnar Pejler

Advanced science (Weinheim, Baden-Wurttemberg, Germany) 9:e2104291 PubMed36031387

2022

Trip13 Depletion in Liver Cancer Induces a Lipogenic Response Contributing to Plin2-Dependent Mitotic Cell Death.

Applications

Unspecified application

Species

Unspecified reactive species

Marcos Rios Garcia,Bettina Meissburger,Jessica Chan,Roldan M de Guia,Frits Mattijssen,Stephanie Roessler,Andreas L Birkenfeld,Nathanael Raschzok,Fabien Riols,Janina Tokarz,Maude Giroud,Manuel Gil Lozano,Goetz Hartleben,Peter Nawroth,Mark Haid,Miguel López,Stephan Herzig,Mauricio Berriel Diaz
View all publications

Product promise

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